Brain responses to self- and other- unfairness under resource distribution context: Meta-analysis of fMRI studies.

Under resource distribution context, individuals have a strong aversion to unfair treatment not only toward themselves but also toward others. However, there is no clear consensus regarding the commonality and distinction between these two types of unfairness. Moreover, many neuroimaging studies have investigated how people evaluate and respond to unfairness in the abovementioned two contexts, but the consistency of the results remains to be investigated. To resolve these two issues, we sought to summarize existing findings regarding unfairness to self and others and to further elucidate the neural underpinnings related to distinguishing evaluation and response processes through meta-analyses of previous neuroimaging studies. Our results indicated that both types of unfairness consistently activate the affective and conflict-related anterior insula (AI) and dorsal anterior cingulate cortex/supplementary motor area (dACC/SMA), but the activations related to unfairness to self appeared stronger than those related to others, suggesting that individuals had negative reactions to both unfairness and a greater aversive response toward unfairness to self. During the evaluation process, unfairness to self activated the bilateral AI, dACC, and right dorsolateral prefrontal cortex (DLPFC), regions associated with unfairness aversion, conflict, and cognitive control, indicating reactive, emotional and automatic responses. In contrast, unfairness to others activated areas associated with theory of mind, the inferior parietal lobule and temporoparietal junction (IPL-TPJ), suggesting that making rational judgments from the perspective of others was needed. During the response, unfairness to self activated the affective-related left AI and striatum, whereas unfairness to others activated cognitive control areas, the left DLPFC and the thalamus. This indicated that the former maintained the traits of automaticity and emotionality, whereas the latter necessitated cognitive control. These findings provide a fine-grained description of the common and distinct neurocognitive mechanisms underlying unfairness to self and unfairness to others. Overall, this study not only validates the inequity aversion model but also provides direct evidence of neural mechanisms for neurobiological models of fairness.

Heterogeneity in the co-occurrence of depression and anxiety among adolescents: Results of latent profile analysis.

BACKGROUND: Depression and anxiety co-occur frequently and there is heterogeneity in the co-occurrence of such symptoms; however, few previous studies investigated the heterogeneity based on person-centered perspectives in adolescents. The primary aim of our study was to explore it using latent profile analysis (LPA), a person-centered statistical approach. METHOD: The Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) were used to examine depression and anxiety symptoms in 7422 Chinese adolescents from 23 primary and secondary schools. To investigate latent profiles and assess profile validity, we employed Latent Profile Analysis (LPA), multinomial logistic regression, and analysis of variance. RESULTS: A three-profile model was suggested as the optimum: low (69.9 %), moderate (21.6 %), and high depression/anxiety (8.5 %). Female with higher negative cognitive bias and higher emotional regulation difficulty are more likely to be categorized in the high depression/anxiety group. Internet addiction, academic "Lying flat" and involution are significantly and positively linked with the severity of anxiety and depression. LIMITATIONS: Reliance on self-reported measures may lead to response bias; the cross-sectional design limits our ability to study how symptom profiles and category membership change over time. CONCLUSIONS: Three latent profiles of the co-occurrence of depression and anxiety presented a parallel pattern, which serves as a poignant reminder of the imperative need to identify Chinese adolescents who may be at elevated risk for depression and/or anxiety, and promoting intervention that are meticulously tailored to address the unique symptom presentations of each individual.

A 2-year mental health follow-up study subsequent to COVID-19.

The COVID-19 pandemic has profoundly impacted the mental health and education of college students. This study examined the interrelationships among loneliness, resilience, and COVID-19 fear among college students in Northern Michigan, a region of the United States severely affected by the pandemic. Data were collected from two student cohorts (n = 258), with half surveyed in early 2022 and the other half in mid-2022, two years after pandemic's onset. The Omicron wave peaked in Michigan in January 2022, but by June 2022, cases, hospitalizations, and deaths had significantly declined. Students completed measures of loneliness, resilience, learning difficulty, and psychological symptoms. Key findings are: 1) Participants' fear, loneliness, and academic difficulty decreased over time, reflecting fluctuations in acute situational and emotional states; 2) Unexpectedly, resilience declined from early to mid-2022, suggesting its diminishing protective role under prolonged, pandemic-induced stress; 3) Despite improvements, students continued reporting high academic difficulties. Loneliness, heightened fear, and dampened happiness together contributed to greater academic difficulties; 4) Pre-existing sex differences equalized two years after the pandemic's onset. While modest improvements were noted, enduring academic and mental health impacts signal a need for continued support.

Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala.

Background: Numerous studies characterized how resting-state functional connectivities (rsFCs) of the amygdala were disrupted in emotional disorders and varied with emotional traits, including anxiety. With trait anxiety known to diminish with age, a critical issue concerns disambiguating the effects of age and anxiety on amygdala rsFCs in studying the neural bases of individual differences in anxiety. Methods: Two-hundred adults (83 women) 19-85 years of age underwent fMRI and assessment for trait anxiety. Amygdala rsFC correlates were identified using multiple regression with age and anxiety in the same model for all and separately in men and women. The rsFC correlates were examined for age-anxiety interaction. Results: Anxiety was negatively correlated with amygdala-temporooccipital gyri rsFC in all and in men alone. In women, amgydala rsFC with the thalamus/pallidum, angular/supramarginal gyri, inferior temporal gyrus, and posterior insula correlated positively and rsFC with calcarine cortex and caudate correlated negatively with anxiety. We also observed sex differences in age correlation of amgydala-posterior cingulate cortex/precuneus and -insula/temporoparietal rsFCs, with stronger associations in women. In women alone, anxiety and age interacted to determine amygdala rsFC with the thalamus/pallidum, calcarine cortex, and caudate, with older age associated with stronger correlation between anxiety and the rsFCs. Limitations: The findings need to be validated in an independent sample and further explored using task-based data. Conclusion: Highlighting anxiety- and age- specific as well as interacting correlates of amygdala rsFCs and sex differences in the correlates, the findings may shed light on the neural markers of anxiety.

The roles of risk perception, negative emotions and perceived efficacy in the association between COVID-19 infection cues and preventive behaviors: a moderated mediation model.

Preventive behaviors during the COVID-19 pandemic are especially critical to the protection of individuals whose family members or acquaintances have been infected. However, limited research has explored the influence of infection cues on preventive behaviors. This study proposed an interaction model of environment-cognitive/affective-behavior to elucidate the mechanism by which infection cues influence preventive behaviors and the roles of risk perception, negative emotions, and perceived efficacy in that influence. To explore the relationships among these factors, we conducted a cross-sectional online survey in 34 provinces in China during the first wave of the COVID-19 pandemic. A total of 26,511 participants responded to the survey, and 20,205 valid responses (76.2%) were obtained for further analysis. The moderated mediation results show that infection cues positively predicted preventive behaviors in a manner mediated by risk perception and negative emotions. Moreover, perceived efficacy moderated the influence of infection cues not only on preventive behaviors but also on risk perception and negative emotions. The higher the perceived efficacy, the stronger these influences were. These findings validated our model, which elucidates the mechanisms underlying the promoting effect of infection cues on preventive behaviors during the initial stage of the COVID-19 pandemic. The implications of these results for the COVID-19 pandemic and beyond are discussed.

Cognitive Defusion and Psychological Flexibility Predict Negative Body Image in the Chinese College Students: Evidence from Acceptance and Commitment Therapy.

Body dissatisfaction is a global phenomenon. Despite the significant cultural difference, most research on negative body image was conducted in Western countries. How do cognitive fusion and psychological flexibility relate to negative body image in the Chinese population? In the present study, this question was investigated through the intervention technique, Acceptance and Commitment Therapy (ACT). Here, 86 young Chinese university students with high negative physical self were invited, in which 42 students received 10 sessions of group-based ACT intervention in a clinical setting while the remained acted as the control group with no intervention. Pretests showed no statistical differences in negative body image between these two groups, while both cognitive fusion and psychological flexibility predicted negative body image. Post-pre tests showed no change in the control group, while enhanced cognitive defusion and psychological flexibility in the ACT group. Individual differences in psychological flexibility and cognitive defusion enhancement predicted improved body image. A strong association of implicit body image with Fatness and Shortness changes suggested that although with individual differences, those components could be internalized during the intervention in the College students.

The mechanism of governments' and individuals' influence on protective behaviours during the second wave of COVID-19: a multiple mediation model.

Background: The SARS-CoV-2 virus continues to spread and resurge globally with signs of a second wave, despite actions by governments to curb the COVID-19 pandemic. However, evidence-based strategies to combat COVID-19 recurrence are poorly documented. Objective: To reveal how governments and individuals should act to effectively cope with future waves, this study proposed a preventive model of COVID-19 resurgence. Method: A questionnaire survey was conducted among 1,137 residents of Beijing, where the epidemic reoccurred. Structural equation model was used to explore the mechanism among government intervention, perceived efficacy, positive emotions, posttraumatic growth (PTG) and protective behaviours. Results: Data analysis revealed that during COVID-19 resurgence, government intervention could directly and indirectly influence protective behaviours through individual factors (i.e. perceived efficacy, positive emotions), and PTG could mediate the indirect pathway to protective behaviours. Conclusions: These findings implied that government intervention needs to be integrated with individual factors to effectively control repeated COVID-19 outbreaks.

Antecedentes: El virus SARS-CoV-2 continúa propagándose y resurgiendo a nivel mundial con signos de una segunda ola, a pesar de las acciones de los gobiernos para frenar la pandemia de COVID-19. Sin embargo, las estrategias basadas en evidencia para combatir la recurrencia de COVID-19 están pobremente documentadas.Objetivo: Para revelar cómo deben actuar los gobiernos y las personas para hacer frente de manera efectiva a futuras olas, este estudio propuso un modelo preventivo del resurgimiento de COVID-19.Método: Se realizó una encuesta entre 1.137 residentes de Beijing, donde la epidemia volvió a ocurrir. Se utilizó un modelo de ecuación estructural para explorar el mecanismo entre la intervención del gobierno, la eficacia percibida, las emociones positivas, el crecimiento postraumático (CPT) y las conductas protectoras.Resultados: El análisis de datos reveló que durante el resurgimiento de COVID-19, la intervención del gobierno podría influir directa e indirectamente en los comportamientos de protección a través de factores individuales (es decir, eficacia percibida, emociones positivas), y CPT podría mediar en el camino indirecto hacia los comportamientos de protección.Conclusiones: Estos hallazgos implicaron que la intervención del gobierno debe integrarse con factores individuales para controlar de manera efectiva los brotes repetidos de COVID-19.

The impact of the COVID-19 pandemic on college students in USA: Two years later.

Coronavirus disease 19 (COVID-19) has posed an unprecedented public health challenge for most countries, and the repeated outbreaks of this disease have created a largest disruption of education systems. The intent of this work was to examine the intersection of COVID-19 fear and mental health consequences among college students in Northern Michigan, a region of the U.S. severely affected by the pandemic. This study was conducted from January 17 to February 25, 2022, two years later since the outbreak of the pandemic, and 151 college students (female, 76) were involved. Participants' potential psychological symptoms, anxiety, happiness, learning difficulty, and demographic information were surveyed. We have three main findings. First, 60.3% of students had tested positive for COVID-19, and more female than male students were affected (female, 69.7%; male, 50.7%). Second, there was a high prevalence of mental problems among college students, with 95.7% of the sample experiencing moderate or severe mood disorders. Third, respondents' education was severely affected by the pandemic, averaging a score of 7.6 on a scale of 10 when asked how much their learning quality was affected. They showed increased fear, stress, and decreased happiness, and these were associated with their learning quality change. Given the impact would be far-reaching, not only college students' mental health but also their learning difficulties should be monitored during the pandemic. These findings are alarming and timely, and their implications are discussed.

Patients with Methamphetamine Use Disorder Show Highly Utilized Proactive Inhibitory Control and Intact Reactive Inhibitory Control with Long-Term Abstinence.

Methamphetamine use disorder (MUD) is a chronic brain disorder that involves frequent failures of inhibitory control and relapses into methamphetamine intake. However, it remains unclear whether the impairment of inhibitory control in MUD is proactive, reactive or both. To address this issue, the current study used the conditional stop-signal task to assess proactive and reactive inhibitory control in 35 MUD patients with long-term abstinence and 35 matched healthy controls. The results showed that MUD patients with long-term abstinence had greater preparation costs than healthy controls, but did not differ in performance, implying a less efficient utilization of proactive inhibitory control. In contrast, MUD patients exhibited intact reactive inhibitory control; reactive but not proactive inhibitory control was associated with high sensation seeking in MUD patients with long-term abstinence. These findings suggest that proactive and reactive inhibitory control may be two different important endophenotypes of addiction in MUD patients with long-term abstinence. The current study provides new insight into the uses of proactive and reactive inhibitory control to effectively evaluate and precisely treat MUD patients with long-term abstinence.

Social comparisons differentially affect fair and unfair processing in ultimatum bargaining.

Several theoretical frameworks have attempted to illustrate the influence of social contexts on decision-making and well-being. Traditional economic models assume that absolute income is the crucial determinant of one's well-being, while the comparative models state that social comparisons influence and even determine well-being and decisions. Here we investigated the impact of social comparisons on decision-making using a modified three-player Ultimatum Game and ERP technique. We found two independent effects: First, social comparisons did not affect decision-making when a fair norm was enforced. Second, social comparisons affected fairness consideration for unfair offers only-responders were less likely to accept unfair offers in upward comparisons but more likely to accept unfair offers in downward comparisons. These results revealed that people were envy-free of fair offers while affected mainly by social comparisons when the equality norm was broken. Event-related brain potentials showed that in the early time window (260-320 ms), compared to fair offers, unfair offers elicited a larger negative-going medial frontal negativity (MFN) in upward than parallel and downward comparisons, and in the late stage (320-650 ms), compared to fair offers, unfair offers led to equally less positive-going P300 in upward and downward comparisons relative to parallel comparison. Although partly consistent with the relative standing assumption, both traditional economic models and comparative models require revision to account for the results.

The association between intolerance of uncertainty and Internet addiction during the second wave of the coronavirus disease 2019 pandemic: A multiple mediation model considering depression and risk perception.

Repeated outbreaks of coronavirus disease 2019 (COVID-19) have forced people to shift most of their work and life activities from offline to online, leading to a growing problem of Internet dependence and even Internet addiction. However, the mechanism of the association between COVID-19-related intolerance of uncertainty (COVID-19 IU) and Internet addiction during the second wave of COVID-19 is still unclear. The current study explored the association between COVID-19 IU and Internet addiction as mediated by depression and risk perception based on the Uncertainty-Depression-Perception-Addiction model (UDPA). A total of 1,137 adult participants were recruited, and COVID-19 IU, depression, risk perception, Internet addiction, and demographic variables were analyzed. The results showed that COVID-19 IU was significantly and positively associated with Internet addiction and that this relationship was mediated in parallel by depression and risk perception. Our findings further extend the Interaction of Person-Affect-Cognition-Execution (I-PACE) model from the perspective of applicability in the unique context of COVID-19. Furthermore, the study suggests that individuals could decrease their dependence on the Internet to prevent Internet addiction during the second wave of the pandemic through effective interventions that include lowering COVID-19 IU, improving emotion regulation, and developing reasonable perceptions of risk.

Distributed and Multifaceted Effects of Threat and Safety.

In the present fMRI study, we examined how anxious apprehension is processed in the human brain. A central goal of the study was to test the prediction that a subset of brain regions would exhibit sustained response profiles during threat periods, including the anterior insula, a region implicated in anxiety disorders. A second important goal was to evaluate the responses in the amygdala and the bed nucleus of the stria terminals, regions that have been suggested to be involved in more transient and sustained threat, respectively. A total of 109 participants performed an experiment in which they encountered "threat" or "safe" trials lasting approximately 16 sec. During the former, they experienced zero to three highly unpleasant electrical stimulations, whereas in the latter, they experienced zero to three benign electrical stimulations (not perceived as unpleasant). The timing of the stimulation during trials was randomized, and as some trials contained no stimulation, stimulation delivery was uncertain. We contrasted responses during threat and safe trials that did not contain electrical stimulation, but only the potential that unpleasant (threat) or benign (safe) stimulation could occur. We employed Bayesian multilevel analysis to contrast responses to threat and safe trials in 85 brain regions implicated in threat processing. Our results revealed that the effect of anxious apprehension is distributed across the brain and that the temporal evolution of the responses is quite varied, including more transient and more sustained profiles, as well as signal increases and decreases with threat.

Neural substrates of deficient cognitive control in individuals with severe internet gaming disorder.

BACKGROUND AND AIMS: Internet gaming disorder (IGD) is rapidly becoming a worldwide health concern. The prefrontal-subcortical model of self-regulation emphasizes that an impaired prefrontal cognitive control system and an overwhelming subcortical reward-seeking system are both crucial factors in health problems, including addiction. This study focused on the cognitive control system of IGD, aiming to investigate whether cognitive control is altered and the underlying neural correlates in college students with IGD. METHODS: Thirty college students with IGD and twenty-five matched healthy controls were asked to complete a stop-signal task that measures cognitive control while being monitored by functional magnetic resonance imaging (fMRI). RESULTS: Compared to the controls, only the college students with severe IGD, rather than those with mild IGD, had deficient brain activity involved in inhibitory control and response execution (specifically, the inferior frontal gyrus, anterior cingulate cortex and primary motor cortex); this result implies that cognitive control deficits are closely linked to addiction severity in individuals with IGD. Regarding performance monitoring function, college students with IGD exhibited unabated behavioral and brain activity, as did the control group. CONCLUSIONS: Combined with our previous finding that the subcortical reward system was enhanced in individuals with IGD, the present findings extend the prefrontal-subcortical model of self-regulation from the perspective of IGD in a college student population and thus provide useful insight for the effective prevention and treatment of IGD.

Differential color tuning of the mesolimbic reward system.

Visual wavelengths are not only associated with the subjective experience of color but also have long been thought to regulate affect. Here we examined the attracting rewarding properties of opposite ends of the wavelength spectrum, as well as their individual variation. As reward is multifaceted, we sought convergent evidence from subjective and objective behavioral and attentional indices, as well as its neural reward system bases. On average, short (blue) relative to long (red) wavelengths were judged subjectively more pleasant and had objectively greater behavioral and attentional salience, regulating speed of simple color discriminations and perception of temporal order. Consistent with reward, these color effects were magnified following monetary reinforcement. Pronounced individual differences in color effects were related to reward but not punishment sensitivity, with blue relative to red preference associated with high relative to low reward sensitivity. An fMRI study revealed these individual differences were supported by color-dependent functional coupling between the visual cortices and mesolimbic reward circuitry. Our findings reveal the reward bases of color, demonstrating color is a potent regulator of perception, action, and neural dynamics.

Investigations into ventral prefrontal cortex using mediation models.

The ventral prefrontal cortex (vPFC) is a major focus of investigation in neuroscience, particularly in the studies of emotion and emotion-cognition integration. A crucial question concerning the regulatory function of vPFC is how it is recruited, especially how the function maps onto the structure and determines appropriate behavior. In social exclusion studies, mediation model analyses suggest that vPFC regulates distress by disrupting anterior cingulate cortex (ACC) activities, whereas I recently report (Hu, 2018; Neuropsychologia) that ventral medial prefrontal cortex appears to defend the organism from acute stress by activating ACC. In this review, I synthesize and highlight functional imaging research with mediation analysis that over the past decades has begun to offer new insights into the brain mechanisms underlying vPFC. Toward this end, the first section of the paper outlines a model of the processes and neural systems involved in the interaction of emotion and cognition. The second and third sections survey recent research on emotional regulation with negative and positive pathways, respectively, emanating from vPFC. The fourth section summarizes the current dynamic network findings. Functional mediation analysis helps to identify signals within vPFC and others that are common and/or specific to particular information processing. Finally, I provide a personal perspective of the adoption of mediation model analysis in the investigations into vPFC.

Yellow is for safety: perceptual and affective perspectives.

Is there a link between color and safety? Yellow is often used in safety contexts. Using the Singapore accident record datasets, Ho et al. provided evidence that yellow taxis have fewer accidents than blue taxis (Ho et al. in Proc Natl Acad Sci 114(12):3074-3078, 2017). Does yellow differentially influence attention and action and if so is this related to purely visual or affective factors? Here, we examined the visual priority of yellow relative to luminance matched colors at opposing ends of the wavelength spectrum (i.e., red and blue), using a temporal order judgment task, between color pairs. Despite being matched in arousal, when yellow and blue were pitted against each other, yellow was consistently seen as occurring first, even when objectively appearing second at short stimulus onset asynchronies. Despite being matched in valence, yellow again showed a larger temporal priority when it was pitted against red. Yellow temporal priority bias was modulated by individual differences in regulatory focus, highlighting a potential affective-motivational origin. These results support that yellow is a safety color, having a temporal advantage, and further evidence that colors have special influences on cognition, perception and behavior.

Reward priming eliminates color-driven affect in perception.

Brain and behavior evidence suggests that colors have distinct affective properties. Here, we investigated how reward influences color-driven affect in perception. In Experiment 1, we assessed competition between blue and red patches during a temporal-order judgment (TOJ) across a range of stimulus onset asynchronies (SOAs). During the value reinforcement, reward was linked to either blue (version 1) or red (version 2) in the experiment. The same stimuli then served as test ones in the following unrewarded, unspeeded TOJ task. Our analysis showed that blue patches were consistently seen as occurring first, even when objectively appearing 2nd at short SOAs. This accelerated perception of blue over red was disrupted by prior primes related to reward (vs. neutral) but not perceptional (blue vs. red) priming. Experiment 2 replicated the findings of Experiment 1 while uncoupling action and stimulus values. These results are consistent with the blue-approach and red-avoidance motivation hypothesis and highlight an active nature of the association of reward priming and color processing. Together, the present study implies a link between reward and color affect and contributes to the understanding of how reward influences color affect in visual processing.

Differential temporal salience of earning and saving.

People are often characterized as poor savers. Here we examined whether cues associated with earning and saving have differential salience for attention and action. We first modeled earning and saving after positive and negative variants of monetary reinforcement, i.e., gains versus avoiding loss. Despite their equivalent absolute magnitude in a monetary incentive task, colors predicting saving were judged to appear after those that predicted earning in a temporal-order judgment task. This saving posteriority effect also occurred when savings were framed as earnings that come slightly later. Colors predicting savings, whether they acquired either negative or positive value, persisted in their posteriority. An attentional asymmetry away from money-saved relative to money-earned, potentially contributes to decreased everyday salience and future wealth.

Neural activity to threat in ventromedial prefrontal cortex correlates with individual differences in anxiety and reward processing.

Emotion studies show that ventromedial prefrontal cortex (vmPFC) plays a critical role in negative affect evaluation. Here we investigated two questions: Does the neural sensitivity to threat of bodily harm in vmPFC alter as anxiety levels increase? If the neural sensitivity to threat in vmPFC reflects a kind of general emotional processing, does it predict reward processing? To address these questions, we first recorded participants' self-reported anxiety. In an investigation of neural responses in vmPFC (Session 1), we measured brain activity (fMRI) associated with the anticipation of threat, using a sphere based ROI approach. In a behavioral experiment (Session 2), participants' reward processing efficiency was evaluated when they performed a visual discrimination task in which they had the opportunity to earn cash rewards. We found that across participants, there were tightly coupled associations between signal changes in the vmPFC and self-reported state anxiety. Specifically, participants who showed more activation in vmPFC to threat also exhibited greater behavioral efficiency in reward processing. Path analysis revealed a closely interconnected network of vmPFC (cortical) and VS (ventral striatum, subcortical) which predicted reward processing. Therefore, in addition to negative affect evaluation, neural sensitivity in vmPFC correlated with both anxiety and reward-related metrics. These results support an emerging model in which the vmPFC functions to defend the organism from acute stress and facilitate reward processes.

Highly Conductive and Transparent Reduced Graphene Oxide Nanoscale Films via Thermal Conversion of Polymer-Encapsulated Graphene Oxide Sheets.

Despite noteworthy progress in the fabrication of large-area graphene sheetlike nanomaterials, the vapor-based processing still requires sophisticated equipment and a multistage handling of the material. An alternative approach to manufacturing functional graphene-based films includes the employment of graphene oxide (GO) micrometer-scale sheets as precursors. However, search for a scalable manufacturing technique for the production of high-quality GO nanoscale films with high uniformity and high electrical conductivity is still continuing. Here we show that conventional dip-coating technique can offer fabrication of high quality mono- and bilayered films made of GO sheets. The method is based on our recent discovery that encapsulating individual GO sheets in a nanometer thick molecular brush copolymer layer allows for the nearly perfect formation of the GO layers via dip coating from water. By thermal reduction the bilayers (cemented by a carbon-forming polymer linker) are converted into highly conductive and transparent reduced GO films with a high conductivity up to 104 S/cm and optical transparency on the level of 90%. The value is the highest electrical conductivity reported for thermally reduced nanoscale GO films and is close to the conductivity of indium tin oxide currently in use for transparent electronic devices, thus making these layers intriguing candidates for replacement of ITO films.