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1.
Zhonghua Liu Xing Bing Xue Za Zhi ; 30(2): 167-70, 2009 Feb.
Article in Chinese | MEDLINE | ID: mdl-19565880

ABSTRACT

OBJECTIVE: To study the spatial distribution characteristics of liver cancer in Guangxi so as to provide evidence for the development of control and prevention on liver cancer. METHODS: The average eight year morbidity was computed, using the rates of liver cancer in 2000-2007. The spatial statistics module of GIS was used to conduct spatial autocorrelation analysis, and the disease mapping was drawn, using the Map Info 8.0 software. RESULTS: The average morbidity rate was clustered in Guangxi in the past eight years, with Moran's I index as 0.34 and P value below 0.01. G index appeared to be 0.77 and the P value was below 0.01. Moran's I correlogram lifted up in four spaces, specifically, the cluster took place in both macro-scale (one to three spatial intervals, 45 to 135 km real scale) and micro-scale (16 to 18 spatial intervals, 720 to 800 km real scale). When the spatial interval became 14 and real scale was 60 km, the spatial distribution of liver cancer showed the most intensive autocorrelation. Most of the regions with high morbidity would be clustered in the southwest and southern parts, along the coastal areas of Guangxi while the regions with low morbidity clustered in the northern part of Guangxi. CONCLUSION: Liver cancer was found un-randomly distributed and geographically clustered in Guangxi in 2000-2007.


Subject(s)
Carcinoma, Hepatocellular/epidemiology , Liver Neoplasms/epidemiology , China/epidemiology , Geography , Humans , Incidence , Models, Statistical , Statistical Distributions
2.
Chin Med Sci J ; 20(2): 83-7, 2005 Jun.
Article in English | MEDLINE | ID: mdl-16075743

ABSTRACT

OBJECTIVE: To investigate effect of inhibiting melatonin biosynthesis on activities of protein kinase A (PKA), glycogen synthase kinase-3 (GSK-3) and tau phosphorylation at PS214 and M4 epitopes using haloperidol, a specific inhibitor of 5-hydroxyindole-O-methyltransferase. METHODS: Brain ventricular and intraperitoneal injections were used for haloperidol administration, Western blots for tau phosphorylation, 32P-labeling for PKA and GSK-3 activity, and high performance liquid chromatograph for detection of serum melatonin levels. RESULTS: Haloperidol injection through the lateral ventricle and intraperitoneal reinforcement significantly stimulated PKA activity with a concurrent hyperphosphorylation of tau at M4 (Thr231/Ser235) and PS214 (Ser214) sites. Prior treatment of the rats using melatonin supplement for one week and reinforcement during the haloperidol administration arrested PKA activity and attenuated tau hyperphosphorylation. GSK-3 activity showed no obvious change after haloperidol injection, however, melatonin supplements and reinforcements during haloperidol infusion inactivated basal activity of GSK-3. CONCLUSION: Decreased melatonin may be involved in Alzheimer-like tau hyperphosphorylation, and overactivation of PKA may play a crucial role in this process.


Subject(s)
Cyclic AMP-Dependent Protein Kinases/metabolism , Haloperidol/pharmacology , Hippocampus/metabolism , Melatonin/biosynthesis , tau Proteins/metabolism , Animals , Epitopes , Glycogen Synthase Kinase 3/metabolism , Haloperidol/administration & dosage , Hippocampus/enzymology , Injections, Intraperitoneal , Injections, Intraventricular , Male , Melatonin/blood , Phosphorylation/drug effects , Rats , Rats, Wistar
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