Genome-wide screening for highly discriminative SNPs for personal identification and their assessment in world populations.

The applications of DNA profiling aim to identify perpetrators, missing family members and disaster victims in forensic investigations. Single nucleotide polymorphisms (SNPs) based forensic applications are emerging rapidly with a potential to replace short tandem repeats (STRs) based panels which are now being used widely, and there is a need for a well-designed SNP panel to meet such challenge for this transition. Here we present a panel of 175 SNP markers (referred to as Fudan ID Panel or FID), selected from ∼3.6 million SNPs, for the application of personal identification. We optimized and validated FID panel using 729 Chinese individuals using a next generation sequencing (NGS) technology. We showed that the SNPs in the panel possess very high heterozygosity as well as low within- and among-continent differentiations, enabling FID panel exhibit discrimination power in both regional and worldwide populations, with the average match probabilities ranging from 4.77×10-71 to 1.06×10-64 across 54 world populations. With the advent of biomedical research, the SNPs connecting physical anthropological, physiological, behavioral and phenotypic traits will be eventually added to the forensic panels that will revolutionize criminal investigation.

[Epidemiological survey of cerebrovascular disease among population in Inner Mongolia autonomous region].

OBJECTIVE: To understand the epidemiological characteristics of cerebrovascular disease among population in Inner Mongolia. METHODS: From September 2013 to January 2014, a total of 19 315 local residents in all age groups were selected through cluster random sampling, and face to face questionnaire survey was conducted among them, than health examination was provided for them. RESULTS: The overall prevalence of cerebrovascular diseases among the population in all age group was 1 812.06/100 000 (2 008.86/100 000 in males and 1 613.24/100 000 in females). The prevalence of cerebrovascular diseases increased with age, and the prevalence was higher in males than in females, in rural population than in urban population and in people with lower educational level than in people with higher educational level. The annual incidence stroke was 392.54/100 000, the difference in the incidence between males and females had no statistical significance (χ(2)=0.380, P=0.846). The incidence of stroke was higher in rural population than in urban population, the difference was statistically significant (χ(2)=13.029, P=0.000). The incidence of stroke increased with age (χ(2)=410.130, P=0.000). The annual mortality of stroke was 149.67/100 000 and the case fatality rate was 15.14%. Compared with the elderly, the prevalence of cerebral hemorrhage and cerebral infarction were higher in young people. CONCLUSION: The prevalence, incidence, mortality and recurrence rate of cerebrovascular disease were high in the population in Inner Mongolia, ischemic stroke was the major form of cerebrovascular disease.