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Zhong Yao Cai ; 31(7): 1022-4, 2008 Jul.
Article in Chinese | MEDLINE | ID: mdl-18973021

ABSTRACT

OBJECTIVE: To investigate anti-influenza virus H3N2 effect of Hypericum japonicum in vivo. METHODS: The influences on lung index and death rate were observed in the mice infected with virus H3N2 from intranasal. RESULTS: Experiments in vivo showed that Hypericum japonicum at the concentration of 10 g/kg x d for the intranasal treatment markedly inhibited the lung consolidation of mice pneumonia caused by the infection of influenza virus H3N2 and prolonged the survival time . CONCLUSION: Hypericum japonicum may be effective on treating influenza.


Subject(s)
Antiviral Agents/pharmacology , Drugs, Chinese Herbal/pharmacology , Hypericum/chemistry , Influenza A Virus, H3N2 Subtype/drug effects , Orthomyxoviridae Infections/drug therapy , Animals , Antiviral Agents/isolation & purification , Antiviral Agents/therapeutic use , Drugs, Chinese Herbal/isolation & purification , Drugs, Chinese Herbal/therapeutic use , Female , Lung/drug effects , Lung/pathology , Male , Mice , Orthomyxoviridae Infections/pathology , Orthomyxoviridae Infections/virology , Plants, Medicinal/chemistry , Pneumonia, Viral/pathology , Random Allocation , Ribavirin/administration & dosage , Ribavirin/pharmacology
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