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Biomacromolecules ; 25(5): 2953-2964, 2024 May 13.
Article in English | MEDLINE | ID: mdl-38652682

ABSTRACT

Endoscopic submucosal dissection (ESD) is an effective method for resecting early-stage tumors in the digestive system. To achieve a low injection pressure of the injected fluid and continuous elevation of the mucosa following injection during the ESD technique, we introduced an innovative injectable sodium-alginate-based drug-loaded microsphere (Cipro-ThSA) for ESD surgery, which was generated through an emulsion reaction involving cysteine-modified sodium alginate (ThSA) and ciprofloxacin. Cipro-ThSA microspheres exhibited notable adhesiveness, antioxidant activity, and antimicrobial properties, providing a certain level of postoperative wound protection. In vitro cell assays confirmed the decent biocompatibility of the material. Lastly, according to animal experiments involving submucosal elevation of porcine colons, Cipro-ThSA microspheres ensure surgically removable lift height while maintaining the mucosa for approximately 246% longer than saline, which could effectively reduce surgical risks while providing sufficient time for operation. Consequently, the Cipro-ThSA microsphere holds great promise as a novel submucosal injection material, in terms of enhancing the operational safety and effectiveness of ESD surgery.


Subject(s)
Alginates , Endoscopic Mucosal Resection , Microspheres , Alginates/chemistry , Animals , Swine , Endoscopic Mucosal Resection/methods , Humans , Ciprofloxacin/administration & dosage , Ciprofloxacin/chemistry , Ciprofloxacin/pharmacology , Cysteine/chemistry
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