Indicator-based assessments of the coupling coordination degree and correlations of water-energy-food-ecology nexus in Uzbekistan.

Grappling with the global ecological concern of the Aral Sea disaster, Uzbekistan exemplifies the urgent necessity of unravelling and addressing the complex Water-Energy-Food-Ecology (WEFE) nexus conflicts in arid regions, a critical task yet largely uncharted. Through the strategic process of 'Indicator Articulation - Weight Calibration - Nexus Coordination Quantification - Correlational Analysis', this work has developed a tailored framework that integrates a novel, context-specific indicator system, enabling an illumination of the intricate dynamics within the WEFE nexus in arid regions. During 2000-2018, the WEFE Nexus in Uzbekistan showed low-level coordination, indicating systemic imbalances. The Aral Sea crisis was the central disruptor, resulting in a moderately disordered ecological subsystem. Concurrently, disorder was observed in water resources, signaling inadequate management and potential overutilization. Furthermore, Coordination for energy and food were barely coordinated and under primary coordination respectively, underlining critical challenges in energy efficiency and food security. Over the last two decades, the WEFE Nexus has evolved towards a tighter interlinkage, yet the stability of this coupling coordination has experienced increased fluctuations, indicating that Uzbekistan's policies in the WEFE subsystems have been less stable in the last two decades and are in need of further adjustment and improvement. To address the challenges, we recommend a comprehensive approach that integrates technological, infrastructure, and policy solutions is needed. Specifically, promoting water-saving irrigation technology, renewing and maintaining outdated energy facilities, and raising public awareness of ecological protection are part of the essential measures. Furthermore, alleviating the contradiction between economic growth and ecological conservation remains a major challenge. Collectively, our constructed WEFE Nexus framework, with its extendable and context-specific indicators, holds significant potential for broad application in the analysis of multi-sectoral sustainability, particularly within arid regions globally, and forms a solid foundation for the formulation of effective, targeted policies and sustainable development strategies.

Impacts of climate change and evapotranspiration on shrinkage of Aral Sea.

The massive desiccation of the Aral Sea, the fourth largest lake in the world, has led to severe ecological problems, expansion of cropland was thought to be the main factor driving that shrinkage. But this study performed a long-term land cover and use change assessment for Aral Sea Basin (ASB) to show that the cropland has stopped expanding in 2000, of which the cropland in the ASB plain area has decreased significantly (-140 km2/year) from 2001 to 2019. By contrast, this study finds the hydrological cycle in the ASB has intensified through a spatial and temporal scale approach based on Earth observation. Specifically, there is a 7.21 % (+304.56 × 108 m3) increase in annual total precipitation and a 10.13 % (+376.21 × 108 m3) increase in annual total actual evapotranspiration (AET) for the whole ASB during 1980-2019. In particular, the total annual AET in the ASB plain area has increased by 37.81 % (+718.92 × 108 m3), which almost depletes the water that should have flowed into the Aral Sea. Therefore, the Aral Sea shrank by 5625 × 108 m3 (or 42,944.32km2) from 1980 to 2019. Changing climate and increasing AET have accelerated the desiccation of the Aral Sea, and the expansion of cropland is no longer the main factor of that shrinkage. After more water was conserved in the ASB plain area, evapotranspiration plays a more vital role in the Aral Sea shrinkage. Reducing AET and unproductive water losses are key initiatives in future projects to save the Aral Sea. This study explores the causes of Aral Sea shrinkage from an integrated perspective of climate-land-water-ecological change across the ASB, bridging the limitations of previous studies that have focused on Aral Sea waters and subbasins.

Probing Dynamic Features of Phagosome Maturation in Macrophage using Au@MnOx @SiO2 Nanoparticles as pH-Sensitive Plasmonic Nanoprobes.

Phagosome maturation in macrophage is essential to the clearance of pathogenic materials in host defence but the dynamic features remain difficult to be measured in real time. Herein, we reported the multilayered Au@MnOx @SiO2 nanoparticle as a robust pH-sensitive plasmonic nanosensor for monitoring the dynamic acidification features over the phagosome maturation process in macrophage under darkfield microscopy. For this multilayered nanosensor, the gold nanoparticle core plays a role of signal reporter, the MnOx shell and the outmost SiO2 act as the sensing layer and the protecting layer, respectively. After subject to the acidic buffer solution, the MnOx layer in the multilayered nanoprobe could be decomposed rapidly, resulting in a remarkable spectral shift and color change under darkfield microscopy. We demonstrated this nanosensor for the investigation of single phagosome acidification dynamics by monitoring the color changes of nanoprobes after phagocytosis over time. The nanoprobes after phagocytosized in macrophage displayed a slight color change within the first hour and then cost several minutes to change from red to green in the next stage, indicating the phagosome undergoes a slow first and then fast acidification feature as well as a slow-to-fast acidification translation over the phagosome maturation process. Moreover, we validated that the slow-to-fast acidification translation was dependent on the activation of V-ATPase from the ATP depletion assay. We believed that this nanosensor is promising for studying the dynamic acidification features as well as disorders in phagosome maturation in phagocytic cells, which might provide valuable information for understanding the disease pathogenesis related to phagosome dysfunctions.

Effectiveness of auricular point therapy for cancer-related fatigue: A systematic review and meta-analysis.

AIMS: To systemically review the efficacy and safety of auricular point therapy in patients with cancer-related fatigue. DESIGN: A systematic review and meta-analysis of randomized controlled trials. DATA SOURCES: Eight electronic databases (PubMed, CENTRAL, Embase, CINAHL, Web of Science, China Biology Medicine, China National Knowledge Infrastructure and WanFang Data Knowledge Service Platform) were explored for randomized controlled trials from their inception to 1 December 2018. REVIEW METHODS: The risk of bias assessment tool was adopted in accordance with Cochrane Handbook 5.3.0. All included studies reported the effects on cancer-related fatigue as the primary outcome. Effect size was estimated using relative risk, standardized mean difference or mean difference with a corresponding 95% confidence interval. Review Manager 5.3 was used for meta-analysis. RESULTS: Six studies comprising 394 patients were included. The results of meta-analysis showed that auricular point therapy plus standard care produced more positive effects on cancer-related fatigue and quality of life than standard care alone. It could significantly improve the role, emotional, cognitive, and social functions of patients with cancer-related fatigue. CONCLUSIONS: Auricular point therapy may be a safe therapy to relieve cancer-related fatigue and enhance the quality of life of patients with cancer. However, the evidence was inconclusive due to limitations on the quantity and quality of included studies. Rigorously designed randomized controlled trials should be conducted to verify the results. IMPACT: Auricular point therapy is a simple and safe therapeutic approach that may alleviate cancer-related fatigue of common complications in patients with cancer and it is worth promoting in the community, family, and hospital. Moreover, the research findings can provide suggestions and inspiration for nurses and researchers to implement the proposal, which is conducive to design more rigorous and high-quality randomized controlled trials.

Magnetic chitosan-graphene oxide composite for anti-microbial and dye removal applications.

Magnetic chitosan-graphene oxide (MCGO) nanocomposite was prepared as a multi-functional nanomaterial for the applications of antibacterial and dye removal. The nanocomposite was characterized by scanning electronic microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectrometer (FTIR). The antibacterial performance for MCGO against Escherichia coli was varied depending on the concentration of MCGO. SEM images of E. coli cells demonstrated that the antimicrobial performance of MCGO nanocomposite was possibly due to the damage of cell membrane. This work also explored MCGO's adsorption performance for methyl orange (MO). The experimental parameters including adsorbent mass, pH value, contact time and concentration of MO on the adsorption capacity were investigated. The maximum adsorption capacity of MCGO for MO was 398.08 mg/g. This study showed that the MCGO offered enormous potential applications for water treatment.

[Evaluation of CT and MRI in diagnosis of intranasal encephalomeningocele].

OBJECTIVE: To evaluate the values of CT and MRI in diagnosing intranasal encephalomeningocele. METHOD: The CT and MRI features of 7 cases confirmed by operation and pathology were retrospectively analyzed. RESULT: CT and MRI demonstrated that all cases were encephalomeningocele and 1 case was accompanied with hydrocephalus. MRI demonstrated that the herniation in nasal cavity were glial tissue and meninges, the signals are abnormal cerebrospinal fluid signal and it was attached to intracranial subarachnoid cavity. CONCLUSION: CT and MRI could diagnose encephalomeningocele correctly. CT could clearly manifest the size and location of the defect of cranial base bone, and the location of hernia. MRI was more advantageous than CT in displaying the contents in hernia, and the relationship between hernia and cranial base. Coronal and axial imaging planes with MR T1- and T2-weighted sequences are required to demonstrate intracerebral connection.