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J Affect Disord ; 359: 109-116, 2024 Aug 15.
Article in English | MEDLINE | ID: mdl-38768823

ABSTRACT

BACKGROUND: Inter-hemispheric cooperation is a prominent feature of the human brain, and previous neuroimaging studies have revealed aberrant inter-hemispheric cooperation patterns in patients with major depressive disorder (MDD). Typically, inter-hemispheric cooperation is examined by calculating the functional connectivity (FC) between each voxel in one hemisphere and its anatomical (structurally homotopic) counterpart in the opposite hemisphere. However, bilateral hemispheres are actually asymmetric in anatomy. METHODS: In the present study, we utilized connectivity between functionally homotopic voxels (CFH) to investigate abnormal inter-hemispheric cooperation in 96 MDD patients compared to 173 age- and sex-matched healthy controls (HCs). In addition, we analyzed the spatial correlations between abnormal CFH and the density maps of 13 neurotransmitter receptors and transporters. RESULTS: The CFH values in bilateral orbital frontal gyri and bilateral postcentral gyri were abnormally decreased in patients with MDD. Furthermore, these CFH abnormalities were correlated with clinical symptoms. In addition, the abnormal CFH pattern in MDD patients was spatially correlated with the distribution pattern of 5-HT1AR. LIMITATIONS: drug effect; the cross-sectional research design precludes causal inferences; the neurotransmitter atlases selected were constructed from healthy individuals rather than MDD patients. CONCLUSION: These findings characterized the abnormal inter-hemispheric cooperation in MDD using a novel method and the underlying neurotransmitter mechanism, which promotes our understanding of the pathophysiology of depression.


Subject(s)
Depressive Disorder, Major , Magnetic Resonance Imaging , Humans , Depressive Disorder, Major/physiopathology , Depressive Disorder, Major/metabolism , Female , Male , Adult , Middle Aged , Brain/physiopathology , Brain/diagnostic imaging , Neurotransmitter Agents/metabolism , Cross-Sectional Studies , Case-Control Studies , Functional Laterality/physiology , Receptors, Neurotransmitter/metabolism , Receptor, Serotonin, 5-HT1A/metabolism
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