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J Agric Food Chem ; 61(38): 9160-5, 2013 Sep 25.
Article in English | MEDLINE | ID: mdl-23930581

ABSTRACT

The antiproliferation activity of the ethanol extract of A. cinnamomea mycelium on hepatocellular cancer cells HepG2 was found to be associated with aroma intensity of the broth during fermentation. We hypothesized that some of the volatile compounds are the precursors of the key bioactive component 4-acetylantroquinonol B of this fungus. The major volatile compounds of A. cinnamomea were identified by GC/MS, and they are oct-1-en-3-ol, linalool, methyl phenylacetate, nerolidol, γ-cadinene and 2,4,5-trimethoxybenzaldehyde (TMBA). TMBA and nerolidol were further selected and used as supplements during fermentation. It was found that both of them could increase the production of 4-acetylantroquinonol B and enhance the antiproliferation activity of the fungus. In addition, the TMBA was identified as the most promising supplement for increasing the bioactivity of A. cinnamomea during cultivation.


Subject(s)
4-Butyrolactone/analogs & derivatives , Antineoplastic Agents/metabolism , Antrodia/metabolism , 4-Butyrolactone/analysis , 4-Butyrolactone/biosynthesis , 4-Butyrolactone/pharmacology , Antineoplastic Agents/analysis , Antrodia/chemistry , Cell Proliferation/drug effects , Culture Media/chemistry , Culture Media/metabolism , Cyclohexanones/analysis , Cyclohexanones/pharmacology , Fermentation , Gas Chromatography-Mass Spectrometry , Hep G2 Cells , Humans
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