The influence of different levels of physical activity and sports performance on the accuracy of dynamic lower limbs balance assessment among Chinese physical education college students.

Background: Balance ability is the basis of human actions. Improving the accuracy of dynamic balance assessment can increase the efficiency of sports injury prediction. Objectives: This study aimed to investigate how physical activity and sports performance affect the dynamic balance ability of lower limbs and validate whether the Lower Quarter Y-Balance Test (YBT-LQ) is a reliable predictor of sports injury risk among Chinese physical education college students. Materials and Methods: In total, 169 voluntary participants completed the YBT-LQ at the beginning of a semester and provided some physiological information and an injury report at the end of the semester. The correlation between YBT-LQ performance and selected factors that can affect the dynamic balance control was analyzed based on data statistics. The receiver operating characteristic (ROC) and the area under curve (AUC) of the composite scores of the YBT-LQ were calculated to explore an optimal cutoff value for predicting sports injury risk. Results: The composite scores of the YBT-LQ exhibited strong correlations with both the sports performance level and sports injury, as well as a moderate correlation with physical activity level, age (negative), and metabolic equivalent (MET). In the entire study population, the area under the receiver operating characteristic (ROC) curves for the binary classification of composite YBT-LQ scores of the left and right legs to predict sports injury risk were 0.78 and 0.74, respectively. Stratifying the study participants based on their levels of physical activity and sports performance had an effect on the AUC values of ROC curves. The optimal cutoff scores of the YBT-LQ for predicting sports injury risk were variable, with values more or less than 95%. Specifically, the cutoff scores for participants with the highest level of sports performance were notably higher, reaching up to 106.5% (left) and 107.2% (right). Conclusion: Physical activity and sports performance can influence human dynamic balance control. Composite scores of the YBT-LQ can be used with acceptable efficiency to predict sports injury. Stratifying participants based on their levels of physical activity and sports performance leads to different optimal cutoff values of the YBT-LQ composite scores in predicting sports injury. This approach is preferable to relying solely on a uniform 95% cutoff. It is recommended to analyze individuals with higher levels of sports performance, such as elite athletes, separately from those with lower levels. This is because the former group has a higher optimal cutoff value compared to the latter.

The functional movement screen predicts sports injuries in Chinese college students at different levels of physical activity and sports performance.

Background: Functional Movement Screen (FMS) is used to evaluate the movement quality of an individual. However, the FMS composite score used to predict sports injuries is currently ambiguous. Further refinement of the FMS scoring method may be required to more accurately predict sports injuries. Objectives: To investigate whether FMS scores could accurately predict sports injuries in college students with different levels of physical activity (PA) and sports performance (SP). Methods: One hundred eighty-seven college students aged 18 to 22 were prospectively screened by the FMS test and grouped by the levels of PA and SP. Sports injury occurrences were monitored and collected 12 months later. Spearman's rank coefficients and binary logistic regression were used to identify the risk factors for sports injuries. The receiver operating characteristic (ROC) curve and the total area under the curve (AUC) value were used to determine the optimal FMS cut-off point for sports injuries. Results: The FMS composite score (sum of the seven FMS tests) exhibited a fair association with sports injuries (r = -0.434, P < 0.001). Those with an FMS cut-off point of 17.5 were more likely to acquire sports injuries. The AUC value of the ROC curves was 0.764 (95% CI: 0.618-0.909) in the low PA students, 0.781 (95% CI: 0.729-0.936) in the moderate PA students, and 0.721 (95% CI: 0.613-0.879) in the high PA students. Furthermore, students stratified by SP level showed an AUC value of 0.730 (95% CI 0.607-0.853) in the low SP group and 0.778 (95% CI 0.662-0.894) in the moderate SP group, while it declined to 0.705 (95% CI 0.511-0.800) in the high SP group. The FMS cut-off score successfully identified individuals who reported sports injuries at a higher rate in the low (PA, 84.62%; SP, 90.48%) and moderate (PA, 93.75%; SP, 77.78%) groups than in the high groups (PA, 65.52%; SP, 57.89%). Conclusions: The FMS composite score could be used to predict sports injuries in college students with an FMS cut-off value of 17.5. Population stratification by the levels of PA and SP seems to influence the predictive accuracy of the FMS.

Design, synthesis and evaluation of a series of potential prodrugs of a Bruton's tyrosine kinase (BTK) inhibitor.

BTK has become a particularly attractive therapeutic target in autoimmune diseases and B-cell malignancies, making BTK inhibitors a valuable and important therapeutic option. We present the design, synthesis, and evaluation of a series of prodrugs of a BTK inhibitor with an insoluble 2,5-diaminopyrimidine structure. Tails containing different solubilizing groups were added to the parent molecule via an ester linkage. Prodrug 5a showed good aqueous solubility and could be efficiently converted to the parent in a human plasma stability study. The rational prodrug design was supported by molecular studies and a dramatically reduced BTK kinase-inhibitory potential. Taken together, the chemical, biological, and molecular studies suggest that prodrug derivatization of the 2,5-diaminopyrimidine scaffold could be a potential strategy for advancing this series of BTK inhibitors into the therapeutic arena.

Prediction of individual mortality risk among patients with chronic obstructive pulmonary disease: a convenient, online, individualized, predictive mortality risk tool based on a retrospective cohort study.

Background: Chronic obstructive pulmonary disease (COPD) is a serious condition with a poor prognosis. No clinical study has reported an individual-level mortality risk curve for patients with COPD. As such, the present study aimed to construct a prognostic model for predicting individual mortality risk among patients with COPD, and to provide an online predictive tool to more easily predict individual mortality risk in this patient population. Patients and methods: The current study retrospectively included data from 1,255 patients with COPD. Random survival forest plots and Cox proportional hazards regression were used to screen for independent risk factors in patients with COPD. A prognostic model for predicting mortality risk was constructed using eight risk factors. Results: Cox proportional hazards regression analysis identified eight independent risk factors among COPD patients: B-type natriuretic peptide (hazard ratio [HR] 1.248 [95% confidence interval (CI) 1.155-1.348]); albumin (HR 0.952 [95% CI 0.931-0.974); age (HR 1.033 [95% CI 1.022-1.044]); globulin (HR 1.057 [95% CI 1.038-1.077]); smoking years (HR 1.011 [95% CI 1.006-1.015]); partial pressure of arterial carbon dioxide (HR 1.012 [95% CI 1.007-1.017]); granulocyte ratio (HR 1.018 [95% CI 1.010-1.026]); and blood urea nitrogen (HR 1.041 [95% CI 1.017-1.066]). A prognostic model for predicting risk for death was constructed using these eight risk factors. The areas under the time-dependent receiver operating characteristic curves for 1, 3, and 5 years were 0.784, 0.801, and 0.806 in the model cohort, respectively. Furthermore, an online predictive tool, the "Survival Curve Prediction System for COPD patients", was developed, providing an individual mortality risk predictive curve, and predicted mortality rate and 95% CI at a specific time. Conclusion: The current study constructed a prognostic model for predicting an individual mortality risk curve for COPD patients after discharge and provides a convenient online predictive tool for this patient population. This predictive tool may provide valuable prognostic information for clinical treatment decision making during hospitalization and health management after discharge (https://zhangzhiqiao15.shinyapps.io/Smart_survival_predictive_system_for_COPD/).

Criterion Validity of Functional Movement Screen as a Predictor of Sports Injury Risk in Chinese Police Staff.

The occurrence of sports injury has been proven to be highly associated with injury history. (1) Background: This study aimed to validate the feasibility and effectiveness of the Functional Movement Screen (FMS) as a predictor of sports injury risk for Chinese police staff by exploring the optimal cut-off value of the FMS total score for the identification of previous injury. (2) Methods: More than 160 Chinese police staff were recruited and completed the FMS and interviews. The recorders of 148 (79 females and 69 males) participants met the data analysis requirements. For the goal of evaluating the total score of the FMS as a predictor of sports injury risk, all data underwent statistical analysis, calculation of ROC and AUC, evaluation of threshold validity, and so on. (3) Results: The total score frequency distribution of participants' FMS presented the shape of a normal distribution. The statistical results of the study showed that the FMS composite scores (10.6 ± 2.28) of the police staff with a sports injury history were indeed less than those without an injury history (12.4 ± 2.26). The threshold of a total score of the FMS test that warned of a sports injury risk in Chinese police staff on the basis of a previous injury history was 13.5, with an acceptable AUC value (0.701). In accord with the real social environment and the rule of natural human physiological change, the FMS results of this study showed a distinct deterioration trend with increasing age. (4) Conclusions: The FMS deserves consideration by trainers and clinicians as a pre-exercise physical examination for Chinese police staff to avoid sports injury.

InOOH Bulk Crystals and Ultrathin Nanowires under Compression.

InOOH bulk crystals and ultrathin nanowires have been investigated under high pressures by in situ synchrotron radiation X-ray diffraction measurements at ambient temperature. The anisotropic compression indicates that the b-axis is more compressible than the other two axes in InOOH under hydrostatic conditions. Two inflection points, which are associated with the hydrogen-bond strengthening, can be reflected in the plots of b/c ratio versus pressure (b/c-P plots). The size-induced enhancement of the bulk modulus can be visualized from the P-V plots. By comparing the differences in the compression of bulk InOOH and ultrathin nanowires, it is validated that the nanosize effects play an important role in the high-pressure behaviors of InOOH.

Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As).

BACKGROUND: Wedelolactone (WEL), a medicinal plant-derived coumestan, has been reported to exhibit a diverse range of pharmacological activities. However, the metabolism and disposition of WEL remain unexplored. PURPOSE: The present study aims to investigate the metabolism of WEL in rats and identify the enzymes responsible for forming major WEL metabolites. METHODS: Plasma, urine, feces, and bile samples were collected before and after 50 mg/kg WEL was orally administered to rats. Metabolites were profiled by ultrahigh performance liquid chromatography/quadrupole time-of-flight mass spectrometry and identified by high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy. The in vitro WEL glucuronidation activities of human liver microsomes, human kidney microsomes, human intestine microsomes, and 12 recombinant human uridine diphosphate-glucuronosyltransferase (UGT) isoforms were screened. Molecular docking simulation of the interaction between WEL and UGT1A9 was conducted. RESULTS: WEL underwent extensive metabolism, and 17 metabolites were identified. The major metabolic pathways observed were glucuronidation and methylation. Glucuronic acid was preferentially introduced into 5-OH, whereas no obvious regioselectivity was observed in the methylation of 11-OH and 12-OH. Multiple UGTs, including UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10, were involved in forming WEL glucuronides and O-methylated WEL glucuronides. CONCLUSION: The extensive glucuronidation and methylation is responsible for the low oral bioavailability of WEL in rats. UGT1A1 and UGT1A9 were the major enzymes involved in the glucuronidation of WEL and O-methylated WEL. Molecular docking studies revealed that 5-OH was accessible to the catalytic domain of UGT1As; therefore, 5-OH exhibited a high probability of glucuronidation.