ABSTRACT
We investigate the neutron star (NS) equation of state (EOS) by incorporating multi-messenger data of GW170817, PSR J0030 + 0451, PSR J0740 + 6620, and state-of-the-art theoretical progresses, including the information from chiral effective field theory (χEFT) and perturbative quantum chromodynamics (pQCD) calculation. Taking advantage of the various structures sampling by a single-layer feed-forward neural network model embedded in the Bayesian nonparametric inference, the structure of NS matter's sound speed cs is explored in a model-agnostic way. It is found that a peak structure is common in the cs2 posterior, locating at (2.4-4.8)ρsat (nuclear saturation density) and cs2 exceeds c2/3 at 90% credibility. The non-monotonic behavior suggests evidence of the state deviating from the hadronic matter inside the very massive NSs. Assuming the new/exotic state is featured as it is softer than typical hadronic models or even with hyperons, we find that a sizable (⩾10-3Mâ) exotic core, likely made of quark matter, is plausible for the NS with a gravitational mass above about 0.98MTOV, where MTOV represents the maximum gravitational mass of a non-rotating cold NS. The inferred MTOV=(2.18-0.13+0.27)Mâ (90% credibility) is well consistent with the value of (2.17-0.12+0.15)Mâ estimated independently with GW170817/GRB 170817A/AT2017gfo assuming a temporary supramassive NS remnant formed after the merger. PSR J0740 + 6620, the most massive NS detected so far, may host a sizable exotic core with a probability of ≈0.36.
ABSTRACT
Fully general-relativistic binary-neutron-star (BNS) merger simulations with quark-hadron crossover (QHC) equations of state (EOS) are studied for the first time. In contrast to EOS with purely hadronic matter or with a first-order quark-hadron phase transition (1PT), in the transition region QHC EOS show a peak in sound speed and thus a stiffening. We study the effects of such stiffening in the merger and postmerger gravitational (GW) signals. Through simulations in the binary-mass range 2.5
ABSTRACT
The lung is the most common extra-abdominal metastasis site of colorectal cancer (CRC). This study aimed to investigate the genetic variation of pulmonary metastases (PM) and primary tumors in resectable CRC. The clinical data of 410 patients with PM after CRC surgery and 33 paraffin-embedded tissue samples from January 2012 to July 2019 in our hospital were collected retrospectively. Next, 450-panel gene detection technologies based on next-generation sequencing (NGS) were used to analyze the changes in the gene map and the overall variation in cancer-related genes in PM and primary tumors. After quality control, 19 samples were included in the final gene analysis. The results showed that APC (89.5%), TP53 (89.5%), and KRAS (53%) were the most common mutations in PM and primary tumors, but the gene amplification variation was enriched in primary tumors (4.6% vs. 11.4%). KRAS G12D was the most common site variation of the KRAS gene in both PM and primary tumors of CRC. There was no hotspot mutation in the TP53 locus in CRC, and the TP53 mutation in the PM was consistent with that in the primary lesion. The microsatellite instability (MSI) levels of 10 patients were MSS. The mean tumor mutation burden (TMB) of the primary tumor (5.3 muts·Mb-1) was slightly higher than that of metastasis (5.0 muts·Mb-1). In our institution, the genetic characteristics of resectable PM from CRC may be highly consistent with those of the primary tumor.
