ABSTRACT
AIMS AND OBJECTIVES: To observe the effect of a rehabilitation intervention on the comprehensive health status of patients with hand burns. BACKGROUND: Most studies of hand-burn patients have focused on functional recovery. There have been no studies involving a biological-psychological-social rehabilitation model of hand-burn patients. DESIGN: A randomized controlled design was used. METHODS: Patients with hand burns were recruited to the study, and sixty patients participated. Participants were separated into two groups: (1) The rehabilitation intervention model group (n=30) completed the rehabilitation intervention model, which included the following measures: enhanced social support, intensive health education, comprehensive psychological intervention, and graded exercise. (2) The control group (n=30) completed routine treatment. Intervention lasted 5 weeks. Analysis of variance (ANOVA) and Student's t test were conducted. RESULTS: The rehabilitation intervention group had significantly better scores than the control group for comprehensive health, physical function, psychological function, social function, and general health. The differences between the index scores of the two groups were statistically significant. CONCLUSIONS: The rehabilitation intervention improved the comprehensive health status of patients with hand burns and has favorable clinical application. RELEVANCE TO CLINICAL PRACTICE: The comprehensive rehabilitation intervention model used here provides scientific guidance for medical staff aiming to improve the integrated health status of hand-burn patients and accelerate their recovery. What does this paper contribute to the wider global clinical community?
Subject(s)
Burns/nursing , Exercise Therapy/methods , Hand Injuries/nursing , Health Status , Patient Education as Topic/methods , Rehabilitation Nursing/methods , Social Support , Adaptation, Psychological , Adult , Burns/psychology , Burns/rehabilitation , China , Female , Hand Injuries/psychology , Hand Injuries/rehabilitation , Humans , Male , Middle Aged , Recovery of Function , Treatment Outcome , Young AdultABSTRACT
A coordination compound of 5, 7-dihydrox-4'-methoxyisoflavone and selenium was synthesized and its structure was identified by IR, LC-MS and (1)H-NMR. Its biochemical effects were investigated using bovine serum albumin (BSA) as a target protein molecule, in which process three-dimensional (3D) fluorescence spectra, ultraviolet spectra, circular dichroism (CD) spectra and fluorescence probe techniques were employed. The interaction of SEIF and BSA was discussed by fluorescence quenching method and Förster non-radiation energy transfer theory. The thermodynamic parameters ΔH (θ), ΔG (θ), ΔS (θ) at different temperatures were calculated according to Van't Hoff isobaric equation and the results indicated the interaction was an exothermic as well as a spontaneous process. The binding site was explored by fluorescence probe method using warfarin and ibuprofen as markers. Intramolecular forces which are responsible for maintaining the binding were mainly hydrogen bond and van der Waals power. The average distance from the tryptophan residue in domain II of BSA (donor) to SEIF (acceptor) is 3.57 nm at body temperature. The conformation changes of BSA were investigated by 3D fluorescence and CD spectra.
