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1.
Lik Sprava ; (3-4): 25-30, 2012.
Article in Ukrainian | MEDLINE | ID: mdl-23356133

ABSTRACT

In modern oncology chemotherapy (CT), along with the surgical technique and radiotherapy is a leader in the treatment of cancer patients. More than 60% of patients receiving chemotherapy at different stages of treatment. Recently, modern chemotherapy has become more urgent personal approach to the choice of drugs and their doses, aimed at reducing the toxicity of chemotherapy. Complications of chemotherapy significantly degrade the effectiveness of the treatment of patients with malignant tumors, because they require lower doses of anticancer drug, or lengthening the intervals between cycles of chemotherapy, which affects treatment outcomes and quality of life. This paper presents a literature review of toxic effects of cytostatic drugs on the gastrointestinal tract.


Subject(s)
Antineoplastic Agents/adverse effects , Cytostatic Agents/adverse effects , Gastrointestinal Tract/drug effects , Neoplasms/drug therapy , Adrenal Cortex Hormones/pharmacology , Adrenal Cortex Hormones/therapeutic use , Gastrointestinal Tract/pathology , Humans , Intestinal Mucosa/drug effects , Intestinal Mucosa/pathology , Mouth Mucosa/drug effects , Mouth Mucosa/pathology , Nausea/prevention & control , Neoplasms/pathology , Serotonin Antagonists/pharmacology , Serotonin Antagonists/therapeutic use , Treatment Outcome , Vomiting/prevention & control
2.
Lik Sprava ; (7-8): 94-100, 2000.
Article in Ukrainian | MEDLINE | ID: mdl-16786662

ABSTRACT

Set out in the paper are results of treatment of those patients with carcinoma of the lung, uterine cervix, hysterocarcinoma, breast cancer, malignant thymomas, malignant non-Hodgkin's lymphomas, and lymphogranulematosis having been administered combined, chemoradiation or radiation treatments against the background of a complex of accompanying therapy involving systemic enzymotherapy. Polyenzymic drugs were found to be capable of improving results of treatment of acute radiation reactions and preventing postradiation fibrous changes in the lungs, skin, fatty tissue, soft tissue, liver, kidneys. Thus, systemic enzymotherapy is capable of improving the quality of life and results of treatment of oncological patients.


Subject(s)
Bromelains/therapeutic use , Chymotrypsin/therapeutic use , Hydrolases/therapeutic use , Neoplasms/radiotherapy , Papain/therapeutic use , Radiation Injuries/prevention & control , Radiotherapy , Rutin/analogs & derivatives , Trypsin/therapeutic use , Adolescent , Adult , Aged , Bromelains/administration & dosage , Chymotrypsin/administration & dosage , Drug Combinations , Female , Humans , Hydrolases/administration & dosage , Male , Middle Aged , Papain/administration & dosage , Radiotherapy/adverse effects , Rutin/administration & dosage , Rutin/therapeutic use , Treatment Outcome , Trypsin/administration & dosage
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