1.
Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.
Medchemcomm
; 7(1): 128-131, 2016 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-26877862
ABSTRACT
A screen of 20 compounds identified small molecule adjuvants capable of potentiating anitbiotic activty against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containg an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.