Exploring Gender Differences in Early Weight Change and Variability in Adolescents with Anorexia Nervosa during Inpatient Treatment.

Background: Adolescents' early responses and overall outcomes during anorexia nervosa (AN) treatment may differ by patient gender, raising the question of whether evaluating clinical data during AN treatment may require different criteria. Methods: We investigated, using patient records, whether young men and young women with AN differed in terms of early treatment response (defined as weight change and variability within the first 14 days) and whether early treatment responses predicted treatment outcomes similarly across genders. Results: Weight changes predicted patient discharge weight across all gender groups. Weight variability predicted higher disordered eating psychopathology and higher body image insecurities at discharge. Gender differences emerged only for weight gain, which was more pronounced for young men, and gender modulated the effects of weight gain and variability on general psychopathology outcomes. Conclusions: The present findings suggest that early weight changes and weight variability are similarly important predictors of AN treatment outcomes in adolescents but also hint at possible gender differences in terms of the link between weight change and, respectively, variability on general psychopathology.

The State Urge to be Physically Active-Questionnaire (SUPA-Q): Development and validation of a state measure of activity urges in patients with eating disorders.

OBJECTIVE: Many people, including patients with eating disorders (EDs), experience an increased urge for physical activity. "Trait"-like activity in patients with EDs is assessed by existing questionnaires, but there are few clinically validated assessments of a "state" urge to be physically active. Here, we developed and validated the State Urge to be Physically Active-Questionnaire (SUPA-Q). METHODS: After developing and piloting the items, N = 126 patients with EDs (mostly anorexia nervosa and bulimia nervosa) took part in our mixed-longitudinal validation study with one primary assessment for all patients and a secondary assessment for a subsample of patients. Cronbach's α and split-half-methods served as measures of consistency and reliability. Correlations with other questionnaires were used to determine convergent and divergent validity, and confirmatory factor analysis was used for investigating factorial validity. We used paired-samples t-tests for repeated assessments to investigate change sensitivity. RESULTS: We found the SUPA-Q to be highly consistent, and reliable and to demonstrate convergent, divergent, and factorial validity. The comparison of SUPA-Q scores from repeated assessments within a subsample of patients demonstrated the questionnaire's change sensitivity, Cohen's d = 0.48. Moreover, an increase in SUPA-Q scores was associated with a less positive mood, more anxiety, more body dissatisfaction, more tenseness, less feelings of control, and more stress. DISCUSSION: The newly developed SUPA-Q may help to accentuate the necessity to evaluate and address the acute urge to engage in physical activity in patients with EDs in clinical practice and ultimately support tailoring treatments to patients' unique symptom patterns. The questionnaire is available at https://doi.org/10.17605/OSF.IO/G2YBC.

Sociodemographic and clinical features of men and women with eating disorders: a diagnosis-matched, retrospective comparison among inpatients.

Introduction: Eating disorders (EDs) are among the most severe mental disorders in women and men, often associated with high symptom burden and significant limitations in daily functioning, frequent comorbidities, chronic course of illness, and even high mortality rates. At the same time, differences between men and women with EDs remain poorly explored. Methods: In this study, we compared 104 men to 104 diagnosis-matched women with EDs regarding sociodemographic and clinical features. Using latent class mixture modelling, we identified four distinct patient subgroups based on their sociodemographic features. Results: Men with EDs had significantly higher odds than women to belong to a "single-childfree-working" class. Moreover, while there were few overall differences in ED-related symptoms and general psychopathology between men and women, single-childfree-working men with EDs presented with higher general psychopathology symptoms than men in the other classes. Discussion: We discuss how considering sex and gender along with further sociodemographic differences in EDs may help to improve ED diagnosis and treatment.

Exploratory graph analysis (EGA) of the dimensional structure of the eating disorder examination-questionnaire (EDE-Q) in women with eating disorders.

This study examined the dimensional structure of the German Eating Disorder Examination-Questionnaire (EDE-Q) in clinical groups of women with Anorexia Nervosa (AN; N = 821), Bulimia Nervosa (BN; N = 573), and Binge-Eating Disorder (BED; N = 359) using Exploratory Graph Analyses (EGA). The EGA yielded a 12-item-four-dimension structure for the AN group (subscales "Restraint", "Body Dissatisfaction", "Preoccupation", "Importance"), a 20-item-five-dimension structure for the BN group (subscales "Restraint", "Body Dissatisfaction", "Eating Concern", "Preoccupation", "Importance"), and a 17-item-four-dimension structure for the BED group (subscales "Restraint", "Body Dissatisfaction", "Concern", "Importance"). This first investigation of the EDE-Q's dimensional structure using EGA suggests that the original factor model may be suboptimal for specific clinical ED samples and that alternative scoring should be considered when screening specific cohorts or evaluating the effects of interventions.

Factor structure of the Eating Disorder Examination-Questionnaire (EDE-Q) in adult men with eating disorders.

BACKGROUND: Previous investigations on the Eating Disorder Examination-Questionnaire (EDE-Q) factor structures in men have been restricted to non-clinical settings, limiting conclusions about the factorial validity in men with eating disorders (ED). This study aimed to examine the factor structure of the German EDE-Q in a clinical group of adult men with diagnosed ED. METHODS: ED symptoms were assessed using the validated German version of the EDE-Q. Exploratory factor analysis (EFA) using principal-axis factoring based on polychoric correlations was conducted for the full sample (N = 188) using Varimax-Rotation with Kaiser-Normalization. RESULTS: Horn's parallel analysis suggested a five-factor solution with an explained variance of 68%. The EFA factors were labeled "Restraint" (items 1, 3-6), "Body Dissatisfaction" (items 25-28), "Weight Concern" (items 10-12, 20), "Preoccupation" (items 7 and 8), and "Importance" (items 22 and 23). Items 2, 9, 19, 21, and 24 were excluded due to low communalities. CONCLUSIONS: Factors associated with body concerns and body dissatisfaction in adult men with ED are not fully represented in the EDE-Q. This could be due to differences in body ideals in men, e.g., the underestimation of the role of concerns about musculature. Consequently, it may be useful to apply the 17-item five-factor structure of the EDE-Q presented here to adult men with diagnosed ED.

Gender differences in individuals with obesity and binge eating disorder: A retrospective comparison of phenotypical features and treatment outcomes.

OBJECTIVE: Phenotypical comparisons between individuals with obesity without binge eating disorder (OB) and individuals with obesity and comorbid binge eating disorder (OB + BED) are subject to ongoing investigations. At the same time, gender-related differences have rarely been explored, raising the question whether men and women with OB and OB + BED may require differently tailored treatments. METHOD: We retrospectively compared pre- versus post-treatment data in a matched sample of n = 180 men and n = 180 women with OB or OB + BED who received inpatient treatment. RESULTS: We found that men displayed higher weight loss than women independent of diagnostic group. In addition, men with OB + BED showed higher weight loss than men with OB after 7 weeks of treatment. CONCLUSIONS: The present findings add to an emerging yet overall still sparse body of studies comparing phenotypical features and treatment outcomes in men and women with OB and OB + BED; implications for further research are discussed. CLINICAL TRIAL REGISTRATION: The study was prospectively registered with the German Clinical Trial Register as part of application DRKS00028441.

Gender Differences in Treatment Outcomes for Eating Disorders: A Case-Matched, Retrospective Pre-Post Comparison.

Eating disorders (EDs) are increasingly emerging as a health risk in men, yet men remain underrepresented in ED research, including interventional trials. This underrepresentation of men may have facilitated the development of women-centered ED treatments that result in suboptimal outcomes for men. The present study retrospectively compared pre- vs. post-treatment outcomes between age-, diagnosis-, and length-of-treatment-matched samples of n = 200 men and n = 200 women with Anorexia Nervosa (AN), Bulimia Nervosa (BN), Binge Eating Disorder (BED), or Eating Disorder Not Otherwise Specified (EDNOS), treated in the same setting during the same period, and using the same measurements. Compared to women, men with AN showed marked improvements in weight gains during treatment as well as in ED-specific cognitions and general psychopathology. Likewise, men with BED showed marked weight loss during treatment compared to women with BED; ED-specific cognitions and general psychopathology outcomes were comparable in this case. For BN and EDNOS, weight, ED-specific cognitions, and general psychopathology outcomes remained largely comparable between men and women. Implications for treatments are discussed.

[Psychometric Evaluation of the German-Language Version of the Feedback on Physical Appearance Scale on Female Adolescents With Eating Disorders Plus Adolescents and Women Without Eating Disorders]. / Psychometrische Überprüfung der deutschsprachigen Version der Feedback on Physical Appearance Scale an weiblichen Jugendlichen mit Essstörungen sowie Jugendlichen und Frauen ohne Essstörungen.

Negative body-related feedback is associated with increased body dissatisfaction. The English-language version of the Feedback on Physical Appearance Scale (FOPAS) is an instrument to assess verbal and non-verbal body-related feedback, but a German-language version has not been validated yet. The aim of this study was to evaluate the psychometric properties of its German-language version in a sample of adolescents with eating disorders (n=88) and in a sample of adolescents (n=123) and women (n=228) without eating disorders. Confirmatory factor analyses showed a moderate model fit from the English-language original study. All samples showed acceptable internal consistencies. The retest reliability was also mostly acceptable. Significant positive correlations with questionnaires on eating disorder symptoms (criterion validity), teasing (convergent validity) as well as the expected negative correlation with self-esteem indicated good validity. In addition, the FOPAS was able to differentiate between adolescents with and without eating disorders. To sum up, the German-language FOPAS appears to be suitable to assess verbal and non-verbal body-related feedback in research and practice.

Double standards in body evaluation? How identifying with a body stimulus influences ratings in women with anorexia nervosa and bulimia nervosa.

OBJECTIVE: Women with eating disorders (ED) evaluate their own body more negatively than do women without ED. However, it is unclear whether this negative rating is due to objective bodily features or different standards for one's own body and others' bodies. Therefore, the purpose of this study was to examine whether women with ED apply double standards when rating bodies by disentangling the objective features of one's own body from the feelings of ownership. METHOD: We presented n = 34 women with anorexia nervosa, n = 31 women with bulimia nervosa, and n = 114 healthy controls with pictures of thin, average-weight, overweight, athletic, and hypermuscular bodies. Identity was manipulated by showing each body once with the participant's own face and once with the face of another woman. Participants were instructed to report their emotional state according to valence and arousal and to rate body attractiveness, body fat, and muscle mass. RESULTS: Women with anorexia nervosa and bulimia nervosa displayed greater self-deprecating double standards in body fat rating than did women without ED, as quantified by the difference between the ratings of the same body with one's own versus another woman's face. Double standards reflected in valence, arousal and attractiveness ratings were significantly more pronounced in women with anorexia nervosa than in women without ED. DISCUSSION: The double standards found may be due to an activation of dysfunctional self-related body schemata, which distort body evaluation depending on identity. Double standards related to body fat were characteristic for women with ED, but not for women without ED.

[Assessment of Body-Related Avoidance Behaviour: Validation of the German Version of the Body Image Avoidance Questionnaire (BIAQ) in Adolescents with Anorexia and Bulimia Nervosa and Healthy Controls]. / Körperbezogenes Vermeidungsverhalten: Validierung des deutschsprachigen Body Image Avoidance Questionnaire (BIAQ) an Jugendlichen mit Anorexia und Bulimia Nervosa sowie einer gesunden Kontrollgruppe.

Body image avoidance is conceptualised as a behavioural manifestation of body image disturbance, and describes efforts to avoid confrontation with one's own body. While studies have provided hints that body image avoidance in adulthood contributes to the development and maintenance of eating disorders, so far, there are no corresponding findings for adolescence. The Body Image Avoidance Questionnaire (BIAQ) is the most widely used international questionnaire for measuring body-related avoidance behaviour. As its German version has only been validated in an adult sample, the aim of the present study is to statistically test the questionnaire in adolescents with eating disorders. In total, N=127 female adolescents, including n=57 with Anorexia Nervosa, n=24 with Bulimia Nervosa, and n=46 healthy controls, answered the BIAQ as well as various other instruments for assessing body image disturbance and eating disorder symptoms. The factor structure assumed for the original English version, comprising the higher-order factor "body-related avoidance behaviour" and the 4 subfactors "clothing", "social activities", "eating restraint" and "grooming and weighing", was confirmed by a confirmatory factor analysis. With the exception of the scale "grooming and weighing", all scales showed mostly acceptable internal consistencies, test-retest reliability, differential validity and construct validity. Due to their satisfying psychometric properties, the use of the BIAQ scales "clothing", "social activities" and "eating restraint" can be recommended in research and practice for adolescence.

Visual processing of one's own body over the course of time: Evidence for the vigilance-avoidance theory in adolescents with anorexia nervosa?

OBJECTIVE: The vigilance-avoidance theory postulates a specific threat-related pattern of attention deployment, characterized by initial orientation towards fear-evoking stimuli and subsequent directing of attention away from them. The current eye-tracking study was the first to examine the applicability of the theory for patients with eating disorders, who perceive their own body as a highly aversive, threat-evoking stimulus. METHOD: N = 56 female adolescents with anorexia nervosa (AN) and n = 43 healthy controls (HC) aged 13-18 viewed own-body pictures while their eye movements were recorded. Relative fixation times on self-defined unattractive body areas were compared between the groups by sequencing the overall presentation time of 6,000 ms into six intervals à 1,000 ms. RESULTS: Participants with AN showed a significantly stronger attentional bias for unattractive body areas than HC within the time intervals 1, 2, and 3. However, for intervals 4, 5, and 6, no significant group differences occurred. Within the AN group, the bias for unattractive body areas was significantly stronger in interval 1 compared to intervals 4, 5, and 6; whereas within the HC group, a stable pattern of attention deployment emerged. In AN, early attention deployment was positively correlated with the negative affect reported after photo presentation. DISCUSSION: The early vigilance in AN and the subsequent decrease in attention to unattractive body parts is in line with our assumptions. However, no indication of attentional avoidance was found. The current findings partially support the vigilance-avoidance theory for the exposure to one's own body in adolescents with AN.

Selective Visual Attention Towards Oneself and Associated State Body Satisfaction: an Eye-Tracking Study in Adolescents with Different Types of Eating Disorders.

The development of eating disorders is associated with a body-related attentional bias. Although eating disorders are especially prevalent in adolescence, so far, no study has analyzed gaze patterns and state body image in response to viewing one's own body in youth. To fill this gap, the present study aimed to examine a body-related attentional bias and state body satisfaction in adolescents with various forms of eating disorders. Girls with anorexia nervosa, restrictive type (AN-R; n = 30), anorexia nervosa, binge eating/purging type (AN-BP; n = 26), bulimia nervosa (BN; n = 22), clinical controls with anxiety disorders (n = 20) and healthy controls (n = 43) looked at photographs of their own and a peer's body, while their spontaneous eye movements were recorded. After stimulus presentation, state body satisfaction and individual attractiveness ratings for areas of the presented stimuli were assessed. An analysis of variance revealed that participants of all subgroups showed an attentive preference for unattractive areas of one's own body. Girls with AN-R attended significantly longer to unattractive body areas than both control groups and significantly shorter to attractive body areas than healthy controls. State body dissatisfaction was more prominent in all eating disorder subgroups, with significantly lower scores in BN compared to AN-R. In general, the higher the state body dissatisfaction, the stronger was the deficit orientation on one's own body. The attentional bias towards unattractive body areas, which is most pronounced in AN-R, indicates that interventions aiming to modify distorted attention might be promising in the prevention and treatment of eating disorders in adolescence.

[Validation of a German-language Version of the Body Checking Questionnaire (BCQ) in Adolescents with Anorexia and Bulimia Nervosa]. / Validierung einer deutschsprachigen Fassung des Body Checking Questionnaire (BCQ) an Jugendlichen mit Anorexia und Bulimia Nervosa.

Body-related checking behavior, as a behavioral manifestation of a disturbed body image, fosters the development and maintenance of eating disorders. The Body Checking Questionnaire (BCQ) is the most commonly used questionnaire for measuring body-related checking behavior internationally. To date, validation studies are only available for adult populations. Therefore, the aim of this study was to statistically test the German-language version of the BCQ in adolescents. A total of N=129 female adolescents were examined, comprising n=57 with Anorexia Nervosa, n=24 with Bulimia Nervosa, and n=48 healthy female adolescents. A confirmatory factor analysis supports the subdivision of the BCQ into a general factor and the subfactors "overall appearance", "specific body parts" and "idiosyncratic checking", which was also found in the original version. The internal consistencies are good (α≥0.81), and the BCQ is able to differentiate well between adolescents with and without eating disorders. Significant correlations between the BCQ and other body image questionnaires point to a good convergent validity. The German-language BCQ thus constitutes a valid and reliable instrument for measuring body-related checking behavior among adolescents in clinical research and practice.

Primary stent angioplasty of the inferior vena cava after liver transplantation and liver resection.

PURPOSE: This study evaluated technical efficacy and safety of stent angioplasty of the inferior vena cava (IVC) after liver transplantation or liver resection and analysis of changes in creatinine levels and patients' weight. METHODS: Between October 2004 and February 2011, 16 patients (mean age, 52.6 years) with symptomatic IVC stenoses after liver transplantation (n = 10) or liver resection (n = 6) were subjected to stent angioplasty. Enrollment criteria included edema and/or ascites. The smallest diameter of the IVC, serum creatinine values, and patients' weight were assessed before and after stent placement and respective values were compared. Technical and clinical success, patency rates, related complications, and patients' survival were analyzed. RESULTS: Stent placement was technically successful in 16 patients (100 %). Clinical success was achieved in 13 patients (81.25 %), reflecting two patients with early restenosis and one patient suffering from thrombosis distal to the stent. Mean follow-up was 372 days. Primary patencies were 75 % (n = 12). Primary assisted patencies were 93.75 % (n = 15). Serum creatinine levels decreased significantly (p = 0.01) from 1.68 mg/dl before to 1.08 mg/dl after stent placement. Patients' weight decreased (mean 2.1 %). No angioplasty-related complications occurred. CONCLUSIONS: Stent angioplasty of the IVC is an effective and safe treatment of stenoses after liver transplantation and resection and has a positive effect on creatinine levels.

[Development and validation of a German questionnaire assessing motivation to change in eating disorders - the Stages of Change Questionnaire for Eating Disorders (SOCQ-ED)]. / Entwicklung und Validierung einer deutschsprachigen Skala zur Erfassung der Veränderungsmotivation bei Essstörungen - The Stages of Change Questionnaire for Eating Disorders (SOCQ-ED).

The present study describes the development and validation of a German questionnaire assessing motivation to change in individuals with eating disorders (Stages of Change Questionnaire-Eating Disorders, SOCQ-ED). The SOCQ-ED measures stages of change separately for each eating disorder symptom domain. Psychometric properties were assessed in a sample of N=63 women with Anorexia Nervosa or Bulimia Nervosa. Test-retest reliability ranged from rtt=0.42 to 0.78 (Mdn=0.56), correlations with the University of Rhode Island Change Assessment were between r=0.21 and 0.32 and correlations with measurements of eating pathology ranged from r=0.19 to 0.46. The results provide initial support for the reliability and validity of the SOCQ-ED.