ABSTRACT
Homogenized autogenous nucleus pulposus was injected into the lumbar epidural space of four dogs through an indwelling catheter. After daily injections of the material over 5 to 7 days, the dogs were killed at 5, 7, 14, or 21 days after the first injection. In four dogs that served as controls, normal saline was injected on an identical schedule and the dogs were killed at times identical to the experimental group. Evaluation of the dural sac, the spinal cord and its roots was performed by gross inspection and microscopic analysis. There was evidence of an inflammatory response to the nuclear material injected, but no inflammatory response occurred in the control group.
Subject(s)
Back Pain/etiology , Intervertebral Disc Displacement/complications , Meningitis/etiology , Animals , Dogs , Dura Mater , Female , MaleABSTRACT
An 8-year-old girl with a progressive, painless spinal deformity is presented. She was found to have an atypical scoliosis secondary to a stage 3 benign osteoblastoma of the rib. This case is presented to emphasize that atypical scoliosis in skeletally immature individuals requires a thorough investigation for an underlying cause.
Subject(s)
Bone Neoplasms/diagnostic imaging , Osteoma, Osteoid/diagnostic imaging , Ribs/diagnostic imaging , Scoliosis/diagnostic imaging , Bone Neoplasms/pathology , Child , Female , Humans , Osteoma, Osteoid/pathology , Ribs/pathology , Scoliosis/pathology , Tomography, X-Ray ComputedABSTRACT
Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of patients with Ollier's disease will develop a malignant bone neoplasm, most probably chondrosarcoma. The prognosis for most patients is good. Five of the 16 patients survived more than 13 years after treatment.
