ABSTRACT
The influence of the infusion therapy on enzymatic link of antioxidant defense in the small bowel tissue in severe combined trauma of abdominal cavity organs was studied. The best indices of survival in 24 h and changes of the superoxiddysmutase and catalase activity in animals, to whom preparation HAES-LX5% was prescribed.
Subject(s)
Antioxidants/metabolism , Catalase/metabolism , Fluid Therapy/methods , Intestine, Small/injuries , Multiple Trauma/therapy , Superoxide Dismutase/metabolism , Animals , Hydroxyethyl Starch Derivatives/administration & dosage , Intestine, Small/enzymology , Male , Multiple Trauma/enzymology , Plasma Substitutes/administration & dosage , Rats , Rats, Wistar , Trauma Severity Indices , Treatment OutcomeABSTRACT
The changes in the late apoptosis intensity in lymphocytes, obtained from various organs under polytrauma impact, were studied in experiment. In laboratory animals of a control group the late apoptosis intensity appeared essentially bigger in pulmonary lymphocytes, comparing with those from the heart and the liver. Nonsignificant changes of intensity prolong 2 h - 3 days with essential increase in 7 days, decrease--on the 14-21th days and repeated increase--on the 28th day were characteristic in the polytrauma dynamics for late apoptosis in the lymphocytes, obtained from the lungs, the heart and the liver. It is more characteristic for pulmonary lymphocytes, significantly less--for those from the heart and even lesser--from the liver.
Subject(s)
Apoptosis , Liver/pathology , Lung/pathology , Lymphocytes/pathology , Multiple Trauma/pathology , Myocardium/pathology , Animals , Disease Models, Animal , Male , Rats , Time FactorsABSTRACT
In experiment on white rats was evaluated the positive effect of food deprivation on heart damaged by norephynephrine. Magneto-laser irradiation increased the adaptive resources of cardiovascular system during food deprivation and norephynephrine myocardiodystrophy.
Subject(s)
Cardiomyopathies/physiopathology , Food Deprivation/physiology , Heart/radiation effects , Lasers , Magnetics , Adaptation, Physiological/radiation effects , Analysis of Variance , Animals , Cardiomyopathies/chemically induced , Cardiomyopathies/pathology , Epinephrine , Homeostasis/physiology , Homeostasis/radiation effects , Male , Myocardial Contraction/radiation effects , Myocardium/pathology , RatsABSTRACT
The influence of percutaneous magnetolazer irradiation of the blood and liver on the bile secretion, general bilirubin excretion and its fractions, cholesterol and bile acids rate was studied experimentally on male rats. A laser generator "Luch-2" with a magnetic nozzle (wave-length 0.82 mm, power density 0.178 W.cm-2, magnetic field tension 30-35 mT, the course s 2 daily procedures) was used. Bile secretion intensity was noted to depend on the dose. Maximal bile secretion and its basic components were observed during the liver irrigation with an exposition for 120 s and blood ones with an exposition for 240 s respectively. Bile secretion rate was higher during magnetolazer influence on the blood. Liver irrigation was associated with an increased secretion of the conjugated bilirubin. Thus, there are various stimulant mechanisms of the liver function activity in the course of magnetolazer influence on the liver and blood.
Subject(s)
Bile/radiation effects , Blood/radiation effects , Lasers , Liver/radiation effects , Magnetics , Animals , Bile/metabolism , Magnetics/instrumentation , Male , Rats , Secretory Rate/radiation effects , Time FactorsABSTRACT
Intracardial and systemic hemodynamics have been studied in 107 healthy men aged 18-24 years during their functional rest and physical loads of 60 Wt. The echocardiographic method with hard fixation of an echo sensor was applied. Normal values of the heart functional volumes, heart output, ino- and chronotropic activity, arterial pressure and myocardial energy exchange were determined during the functional rest and under physical loads.
Subject(s)
Exercise/physiology , Heart/physiology , Hemodynamics/physiology , Adolescent , Adult , Analysis of Variance , Echocardiography , Electrocardiography , Humans , Male , Reference Values , Rest/physiologyABSTRACT
Experiments with adult (8-10 months) and old (24-26 months) male rats were carried out to investigate the effect of stress on the values of central hemodynamics and inotropic cardiac function--stroke volume, minute volume, stroke index, as well as output volume rate, output volume rate index and systolic frequency. It is found that stress causes more significant disturbance of inotropic function in old rats as compared with adult animals. This disorder occurs earlier in old rats. Probably it is a result of more pronounced damaging effect of the stress on the myocardium of old rats against the background of decreased compensatory systemic abilities.