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1.
A pusher plate pump for tatally implantable left ventricular assist device systems.
Daly, B D; Hagen, K G; Fuqua, J M; Igo, S R; Huffman, F N; Norman, J C.
J Surg Res ; 18(6): 597-605, 1975 Jun.
Article in English | MEDLINE | ID: mdl-1127919

Subject(s)
Assisted Circulation/instrumentation , Animals , Bilirubin/blood , Bioelectric Energy Sources/instrumentation , Blood Flow Velocity , Blood Pressure , Cardiac Output , Cattle , Evaluation Studies as Topic , Heart Rate , Nuclear Fission , Prothrombin Time , Temperature
2.
Nuclear-fueled cardiac pacemakers.
Huffman, F N; Norman, J C.
Chest ; 65(6): 667-72, 1974 Jun.
Article in English | MEDLINE | ID: mdl-4598870

Subject(s)
Pacemaker, Artificial , Radioisotopes , Aged , Alloys , Animals , Bioelectric Energy Sources , Costs and Cost Analysis , Humans , Nuclear Medicine , Oxides , Plutonium , Promethium , Radiation Dosage , Scandium , Thermal Conductivity
3.
NUCLEAR-FUELED CIRCULATORY SUPPORT SYSTEMS IV: RADIOLOGIC PERSPECTIVES.
Huffman, F N; Norman, J C.
Cardiovasc Dis ; 1(5): 463-476, 1974.
Article in English | MEDLINE | ID: mdl-15215965

ABSTRACT

If an implantable artificial heart can be developed, it should prove beneficial to a significant group of patients. A variety of energy sources, such as biologic, electromagnetic, and nuclear, are under evaluation. Currently, biologic fuel cell technology is not sufficiently advanced to permit its extrapolation to the power levels required for implantable circulatory support systems. Electromagnetic systems have the disadvantage of heavy batteries of considerable bulk requiring frequent recharging. Radioisotope-fueled thermal engine systems have the potential of providing degrees of freedom not possible with rechargeable units. However, radiosotope circulatory support systems subject their recipients to prolonged intracorporeal radiation, add to environmental background radiation, and constitute an exceedingly small, but finite, hazard due to possible violation of fuel containment.

4.
An electrically actuated left ventricular assist device (E-A LVAD) in vivo testing.
Aldrich, J G; Chambers, J A; Daly, B D; Migliore, J J; Newgard, P; Huffman, F N; Norman, J C.
Trans Am Soc Artif Intern Organs ; 20 B: 655-9, 1974.
Article in English | MEDLINE | ID: mdl-4450313

Subject(s)
Assisted Circulation/instrumentation , Animals , Blood Pressure , Cardiac Output , Cattle , Electrocardiography , Electronics, Medical , Heart Ventricles
5.
An abdominal left ventricular assist device (ALVAD): chronic hemodynamic analyses in the calf.
Robinson, W J; Igo, S R; Daly, B D; Migliore, J J; Hughes, D A; Edmonds, C H; Fuqua, J M; Huffman, F N; Norman, J C.
Trans Am Soc Artif Intern Organs ; 20 B: 709-20, 1974.
Article in English | MEDLINE | ID: mdl-4450319

Subject(s)
Assisted Circulation , Hemodynamics , Animals , Assisted Circulation/instrumentation , Blood Pressure , Cardiac Output , Cattle , Electronics, Medical , Heart Rate , Heart Ventricles , Polyurethanes , Venous Pressure
6.
Nuclear-fueled circulatory support systems XII: current status.
Hughes, D A; Faeser, R J; Daly, B D; Edmonds, C H; Feigenbutz, L V; Igo, S R; Hagen, K; Migliore, J J; Ruggles, A E; Robinson, W J; Huffman, F N; Norman, J C.
Trans Am Soc Artif Intern Organs ; 20 B: 737-46, 1974.
Article in English | MEDLINE | ID: mdl-4450322

Subject(s)
Assisted Circulation/instrumentation , Hemodynamics , Nuclear Energy , Alkaline Phosphatase/blood , Animals , Aspartate Aminotransferases/blood , Bilirubin/blood , Blood Cell Count , Blood Platelets , Blood Pressure , Blood Urea Nitrogen , Body Temperature Regulation , Cattle , Creatinine/blood , Hemoglobins/metabolism , L-Lactate Dehydrogenase/blood , Prothrombin Time , Temperature , Thermodynamics
7.
An implantable nuclear-fueled circulatory support system V: acute physiologic analyses.
Huffman, F N; Migliore, J J; Hagen, K; Daly, B D; Robinson, W J; Ruggles, A E; Norman, J C.
J Cardiovasc Surg (Torino) ; Spec No: 698-705, 1973.
Article in English | MEDLINE | ID: mdl-4806937

Subject(s)
Assisted Circulation/instrumentation , Heart, Artificial/instrumentation , Nuclear Medicine , Animals , Assisted Circulation/methods , Cattle , Heart, Artificial/methods
8.
Implantable nuclear power sources for artificial hearts: progress report, two years after implantation in the dog.
Norman, J C; Huffman, F N; Molokhia, F A; Asimacopoulos, P J; Warren, S.
Bull Soc Int Chir ; 32(1): 62-74, 1973.
Article in English | MEDLINE | ID: mdl-4721670

Subject(s)
Heart, Artificial , Animals , Dogs , Female , Male , Nuclear Medicine , Plutonium , Prosthesis Design , Radiation Effects , Radioisotopes
9.
An abdominal left ventricular assist device: experimental physiologic analyses. II.
Robinson, W J; Migliore, J J; Arthur, J; Fuqua, J M; Dove, G B; Coleman, S; Huffman, F N; Norman, J C.
Trans Am Soc Artif Intern Organs ; 19: 229-34, 1973.
Article in English | MEDLINE | ID: mdl-4722737

Subject(s)
Assisted Circulation , Abdomen , Animals , Aorta, Abdominal , Assisted Circulation/instrumentation , Blood Pressure , Cardiac Output , Cardiac Volume , Dogs , Heart Rate , Heart Ventricles , Methods , Myocardium/metabolism , Oxygen Consumption , Prosthesis Design , Time Factors
10.
Nuclear-fueled circulatory support systems.
Norman, J C; Harmison, L T; Huffman, F N.
Arch Surg ; 105(4): 645-7, 1972 Oct.
Article in English | MEDLINE | ID: mdl-5071171

Subject(s)
Heart, Artificial/instrumentation , Nuclear Medicine/instrumentation , National Institutes of Health (U.S.) , Plutonium , Research , United States
11.
An implantable nuclear-fueled circulatory support system. I. Systems analysis of conception, design, fabrication and initial in vivo testing.
Norman, J C; Molokhia, F A; Harmison, L T; Whalen, R L; Huffman, F N.
Ann Surg ; 176(4): 492-502, 1972 Oct.
Article in English | MEDLINE | ID: mdl-5077410

Subject(s)
Assisted Circulation/instrumentation , Nuclear Medicine , Plutonium , Animals , Body Surface Area , Body Temperature , Cattle , Curium , Energy Transfer , Fossil Fuels , Heart Rate , Hot Temperature , Radiation
12.
Current studies with simulated nuclear-powered left ventricular assist devices.
Whalen, R L; Molokhia, F A; Jeffery, D L; Huffman, F N; Norman, J C.
Trans Am Soc Artif Intern Organs ; 18(0): 146-51, 157, 1972.
Article in English | MEDLINE | ID: mdl-4679868

Subject(s)
Assisted Circulation/instrumentation , Hot Temperature , Nuclear Reactors , Animals , Body Temperature Regulation , Cattle , Electronic Data Processing , In Vitro Techniques , Models, Biological , Plutonium , Surgical Procedures, Operative , Thermodynamics , Ventricular Function
13.
Abdominal implants of strontium 90-Americium 241/beryllium sources. Stimulation of radiation fields from nuclear powered artifical hearts.
Ponn, R B; Molokhia, F A; Huffman, F N; Curtis, G W; Norman, J C.
Arch Surg ; 103(6): 701-4, 1971 Dec.
Article in English | MEDLINE | ID: mdl-5120194

Subject(s)
Americium , Beryllium , Heart, Artificial , Radiation Effects , Strontium Isotopes , Abdomen , Adipose Tissue/radiation effects , Animals , Bone Marrow/radiation effects , Dogs , Female , Neoplasms, Radiation-Induced , Ovary/radiation effects , Spleen/radiation effects
14.
Electron microscopy and thermal analysis of neointima heated and irradiated in vivo for two years.
Liss, R H; Huffman, F N; Warren, S; Norman, J C.
Ann Thorac Surg ; 12(3): 251-61, 1971 Sep.
Article in English | MEDLINE | ID: mdl-5112479

Subject(s)
Heart Valve Prosthesis , Hot Temperature , Radiation Effects , Animals , Aorta, Thoracic/anatomy & histology , Aorta, Thoracic/surgery , Benzalkonium Compounds , Blood Platelets/radiation effects , Carbon , Collagen , Dogs , Epithelium/radiation effects , Fibrin , Fibroblasts/radiation effects , Heart Valve Prosthesis/instrumentation , Heart, Artificial , Heparin , Leukocytes/radiation effects , Macrophages/radiation effects , Microscopy, Electron , Microscopy, Electron, Scanning , Plutonium , Tantalum , Thermal Conductivity , Time Factors
15.
Performance of a tuned ferrite core transcutaneous transformer.
Fraim, F W; Huffman, F N.
IEEE Trans Biomed Eng ; 18(5): 352-9, 1971 Sep.
Article in English | MEDLINE | ID: mdl-5564367

Subject(s)
Heart, Artificial/instrumentation , Animals , Cattle , Electric Conductivity , Electricity , Magnetics , Skin
16.
Abdominal implants of radiation sources.
Ponn, R B; Molokhia, F A; Huffman, F N; Curtis, G W; Norman, J C.
J Surg Res ; 11(4): 207-9, 1971 Apr.
Article in English | MEDLINE | ID: mdl-5573782

Subject(s)
Abdomen , Heart, Artificial , Plutonium , Radiation Effects , Adipose Tissue/radiation effects , Adrenal Glands/radiation effects , Animals , Bone Marrow/radiation effects , Dogs , Female , Ilium/radiation effects , Kidney/radiation effects , Ovary/radiation effects , Pancreas/radiation effects , Radiometry , Spleen/radiation effects
17.
Heat-induced myocardial angiogenesis, I.
Norman, J C; Molokhia, F A; Asimacopoulos, P J; Liss, R H; Huffman, F N.
Trans Am Soc Artif Intern Organs ; 17: 213-21, 1971.
Article in English | MEDLINE | ID: mdl-5158095

Subject(s)
Coronary Vessels , Hot Temperature , Microcirculation , Animals , Dogs , Female , Fibroblasts , Fluorocarbon Polymers , Male , Myocardium/pathology , Silicones , Stainless Steel
18.
Thrombogenic experience with intravascular heat exchangers.
Huffman, F N; Bernhard, W F; Norman, J C.
Chest ; 58(6): 590-7, 1970 Dec.
Article in English | MEDLINE | ID: mdl-5486554

Subject(s)
Surgical Equipment/adverse effects , Thrombosis/etiology , Animals , Cardiovascular Surgical Procedures , Dogs , Hot Temperature , Methods , Radioisotopes , Vascular Surgical Procedures/instrumentation
19.
Implantable nuclear-powered cardiac pacemakers.
Norman, J C; Sandberg, G W; Huffman, F N.
N Engl J Med ; 283(22): 1203-6, 1970 Nov 26.
Article in English | MEDLINE | ID: mdl-4919592

Subject(s)
Pacemaker, Artificial/instrumentation , Plutonium , Radioisotopes , Animals , Costs and Cost Analysis , Dogs , Humans , Monitoring, Physiologic , Nuclear Medicine , Pacemaker, Artificial/adverse effects , Pacemaker, Artificial/classification , Radiation Effects
20.
Experimental observations of intracorporeal strontium 90-americium 241/beryllium sources simulating radiation fields from nuclear-powered artificial hearts.
Sandberg, G W; Huffman, F N; Norman, J C.
Ann Thorac Surg ; 9(5): 401-9, 1970 May.
Article in English | MEDLINE | ID: mdl-5440802

Subject(s)
Americium , Beryllium , Heart, Artificial , Radiation Effects , Radioisotopes , Strontium Isotopes , Animals , Dogs , Hot Temperature , Longevity , Plutonium
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