How was the Earth-Moon system formed? New insights from the geodynamo.

The most widely accepted scenario for the formation of the Earth-Moon system involves a dramatic impact between the proto-Earth and some other cosmic body. Many features of the present-day Earth-Moon system provide constraints on the nature of this impact. Any model of the history of the Earth must account for the physical, geochemical, petrological, and dynamical evidence. These constraints notwithstanding, there are several radically different impact models that could in principle account for all the evidence. Thus, in the absence of further constraints, we may never know for sure how the Earth-Moon system was formed. Here, we put forward the idea that additional constraints are indeed provided by the fact that the Earth is strongly magnetized. It is universally accepted that the Earth's magnetic field is maintained by a dynamo operating in the outer liquid core. However, because of the rapid rotation of the Earth, this dynamo has the peculiar property that it can maintain a strong field but cannot amplify a weak one. Therefore, the Earth must have been magnetized at a very early epoch, either preimpact or as a result of the impact itself. Either way, any realistic model of the formation of the Earth-Moon system must include magnetic field evolution. This requirement may ultimately constrain the models sufficiently to discriminate between the various candidates.

Strong-field dynamo action in rapidly rotating convection with no inertia.

The earth's magnetic field is generated by dynamo action driven by convection in the outer core. For numerical reasons, inertial and viscous forces play an important role in geodynamo models; however, the primary dynamical balance in the earth's core is believed to be between buoyancy, Coriolis, and magnetic forces. The hope has been that by setting the Ekman number to be as small as computationally feasible, an asymptotic regime would be reached in which the correct force balance is achieved. However, recent analyses of geodynamo models suggest that the desired balance has still not yet been attained. Here we adopt a complementary approach consisting of a model of rapidly rotating convection in which inertial forces are neglected from the outset. Within this framework we are able to construct a branch of solutions in which the dynamo generates a strong magnetic field that satisfies the expected force balance. The resulting strongly magnetized convection is dramatically different from the corresponding solutions in which the field is weak.

Generation of magnetic fields by large-scale vortices in rotating convection.

We propose a self-consistent dynamo mechanism for the generation of large-scale magnetic fields in natural objects. Recent computational studies have described the formation of large-scale vortices in rotating turbulent convection. Here we demonstrate that for magnetic Reynolds numbers below the threshold for small-scale dynamo action, such turbulent flows can sustain large-scale magnetic fields, i.e., fields with a significant component on the scale of the system.

Turbulent magnetic diffusivity tensor for time-dependent mean fields.

We reexamine the nature of the turbulent magnetic diffusivity tensor of mean field electrodynamics and show that the predicted growth rate of the mean field is, in general, incorrect if the tensor is calculated via consideration of time-independent mean magnetic fields. We describe how the traditional expansion procedure for the mean electromotive force should be extended to include time derivatives of the mean magnetic field, and illustrate the consistency of this approach by means of a perturbation analysis for a mean field varying on long spatial scales. Finally, we examine the magnitude of this new contribution to the magnetic diffusion for a particular flow.

SOD antioxidant nanoreactors: influence of block copolymer composition on the nanoreactor efficiency.

The bioavailability limitations of proteins make them difficult to be directly delivered, particularly in diseases caused by insufficient amounts or inactive variants of those proteins. Nanoreactors represent a new promising approach to overcome these limitations because they serve both to protect the protein in their aqueous interior, and simultaneously to allow the protein to act in situ. Here we examine an antioxidant nanoreactor based on SOD encapsulated in amphiphilic block copolymer nanovesicles, and analyze its behavior as a function of the copolymer composition. The membrane of the triblock copolymer nanovesicles plays a double role, both to shield the sensitive protein and selectively to let superoxide and dioxygen penetrate to its inner space. The encapsulation efficiency for different triblock copolymer vesicles was quantified by fluorescence correlation spectroscopy using a fluorescently labeled SOD. Pulse radiolysis experiments and an enzymatic assay were used to compare the permeability of the wall-forming membranes towards superoxide anions. While the encapsulation efficiency mainly depends on the vesicle dimensions, the membrane permeability is mainly affected by the length of the hydrophobic PDMS middle blocks of our polymers. For polymers with very long PDMS chains superoxide anion transport across the membranes was too slow to be detected by our experiments.

Protein delivery: from conventional drug delivery carriers to polymeric nanoreactors.

Due to their low bioavailability, many naturally occurring proteins can not be used in their native form in diseases caused by insufficient amounts or inactive variants of those proteins. The strategy of delivering proteins to biological compartments using carriers represents the most promising approach to improve protein bioavailability. A large variety of systems have been developed to protect and deliver proteins, based on lipids, polymers or conjugates. Here we present the current progress of the carriers design criteria with the help of recent specific examples in the literature ranging from conventional liposomes to polymeric nanoreactors, with sizes from micrometer to nanometer scale, and having various morphologies. The design and optimisation of carriers in the dual way of addressing questions of a particular application and of keeping them very flexible and reliable for general applications represent an important step in protein delivery approaches, which influence considerably the therapeutic efficacy. We examine several options currently under exploration for creating suitable protein carriers, discuss their advantages and limitations that induced the need to develop alternative ways to deliver proteins to biological compartments. We consider that only tailored systems can serve to improve proteins bioavailability, and thus solve specific pathological situations. This can be accomplished by developing nanocarriers and nanoreactors based on biocompatible, biodegradable and non-toxic polymer systems, adapted sizes and surface properties, and multifunctionality to cope with the complexity of the in-vivo biological conditions.

Large-scale dynamo action driven by velocity shear and rotating convection.

By incorporating a large-scale shear flow into turbulent rotating convection, we show that a sufficiently strong shear can promote dynamo action in flows that are otherwise nondynamos. Our results are consistent with a dynamo driven either by the shear-current effect or by a fluctuating alpha effect interacting with the shear, but not with either a classical alpha(2) or alpha omega dynamo.

Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery.

Polymeric formulations (micelles, vesicles etc.) have emerged as versatile drug carriers due to their increased stability, site specificity, blood circulation resistance and thus overall potential therapeutic effects compared to liposomes. Furthermore, stimuli-responsive systems have been developed whose properties change after applying certain external triggers. Polymersomes are mainly composed of amphiphilic block copolymers that are held together in water due to strong physical interactions between the insoluble hydrophobic blocks, thus forming a bilayer morphology or, in the case of triblock copolymers, a bilayer-like morphology. Formation and destabilization of these assemblies is a consequence of external stimuli (temperature, pH, oxidation/reduction conditions etc.). This review focuses on recent developments concerning stimuli- responsive polymersomes made of amphiphilic block copolymers and their potential applications within the biomedical field.

Alpha effect in a family of chaotic flows.

We perform numerical experiments to calculate the kinematic alpha effect for a family of maximally helical, chaotic flows with a range of correlation times. We find that the value of depends on the structure of the flow, on its correlation time and on the magnetic Reynolds number in a nontrivial way. Furthermore, it seems that there is no clear relation between alpha and the helicity of the flow, contrary to what is often assumed for the parametrization of mean-field dynamo models.