Benzodiazepine prescribing and withdrawal for 3234 patients in 15 general practices.

Benzodiazepines are still widely prescribed in general practice, despite repeated warnings about the problems associated with their use. Other studies have shown that a variety of interventions can reduce prescribing, but these have been restricted to relatively few general practices or patients. We co-ordinated an audit of benzodiazepine prescribing and withdrawal in 15 practices caring for 87,900 patients across a district. In total 3234 patients (37 per 1000 registered patients) were discovered to be taking the drugs at the start of the programme, and 16% of these people stopped taking the drugs by the conclusion of the audit 8 months later. There was no relation between success at benzodiazepine cessation and initial levels of prescribing, nor with practice size. Younger patients were significantly more likely to stop benzodiazepines than those over the age of 65.

Protein requirements of mature working horses.

Eighteen mature horses were used to study proteins requirements of working horses. Treatments included intense exercise, medium exercise and maintenance in a 3 X 3 factorial arrangement with three levels of calculated dietary crude protein (CP; 8.5, 7.0 and 5.5%). The horses were on the various exercise-protein treatments for 60 d, then fasted 4 d to evaluate their N status after the treatment period. Exercise had no significant effect on body weight over the feeding and fasting periods. No one exercise or protein treatment expressed the classical low plasma albumin or total protein concentrations of protein-deficient or malnourished animals. Plasma urea N (PUN) concentrations reflected the amount of protein in the diet, with the horses fed the high-protein treatment having the highest PUN concentration (P less than .05). Fasting brought about a significant rise in the urinary percentage of urea + NH3 N, with the highest protein treatment excreting the highest percentage (P less than .05). Because plasma protein concentrations were maintained and labile protein reserves were apparently not depleted, it appears that the lowest protein diet containing 1.9 g digestible protein/W.75 was adequate, regardless of work load.

Serum testosterone levels in young normal horses.

Serum testosterone levels were measured in normal young male horses (29 to 34 weeks old). No differences were found between gelded and intact males. The values for all the horses were low. On the basis of their testosterone levels, all the horses were prepubertal.