Boundary work as a buffer against burnout: Evidence from healthcare workers during the COVID-19 pandemic.

Burnout represents a significant problem for many modern-day workers, but perhaps none more acutely than those in healthcare. Imbued with the chronic stressors that often accompany high-risk, interpersonal work, the healthcare industry is rife with stories of burnout, and the addition of a pandemic has intensified the challenges of an already demanding work environment. With an aim toward understanding the root causes of pandemic-exacerbated burnout, we document the experiences of 93 healthcare workers during the COVID-19 pandemic and, in doing so, explore an important link between burnout and work-nonwork boundaries. We find the contextual shock of the pandemic resulted in an increased incidence of boundary violations-undesired disruptions between work and other important life domains such as personal and family life. These boundary violations-which we classify as physical, temporal, or knowledge-based-frequently corresponded to greater reports of burnout manifested by exhaustion, detachment, and inefficacy. We detail specific patterns within the broader context of boundary violations whereby intrusion events are associated with increased job-related demands and distancing events are associated with reduced job-related resources. In addition to documenting the connection between burnout and boundary violations, we also reveal how workers utilized specific boundary work tactics in response to specific types of boundary violations to redefine boundaries and forestall burnout. Our grounded theorizing points to theoretical and practical implications for the impact of boundary work tactics on burnout and other stress-related phenomena. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Motor proteins regulate force interactions between microtubules and microfilaments in the axon.

It has long been known that microtubule depletion causes axons to retract in a microfilament-dependent manner, although it was not known whether these effects are the result of motor-generated forces on these cytoskeletal elements. Here we show that inhibition of the motor activity of cytoplasmic dynein causes the axon to retract in the presence of microtubules. This response is obliterated if microfilaments are depleted or if myosin motors are inhibited. We conclude that axonal retraction results from myosin-mediated forces on the microfilament array, and that these forces are counterbalanced or attenuated by dynein-mediated forces between the microfilament and microtubule arrays.

Community organizing: an ecological route to empowerment and power.

An important contribution to empowerment theory and community psychology practice can be made by examining how the concept of social power is developed and manifested in the context of community organizing. Theory and practice may be further informed through an ecological analysis of organizing processes and interventions. Lessons from a national community organizing network highlight the relationship between empowerment and power through a set of organizing principles and a cycle of organizing activity. Perhaps most important is the understanding that a reciprocal relationship exists between development of power for community organizations and individual empowerment for organization members. Implications for empowerment theory in the community organizing domain are provided in a matrix adapted from Zimmerman's description of empowerment processes and outcomes at multiple levels of analysis.

Solution conformations of the gamma-carboxyglutamic acid domain of bovine prothrombin fragment 1, residues 1-65.

Molecular dynamics simulations have been performed (AMBER version 3.1) on solvated residues 1-65 of bovine prothrombin fragment 1 (BF1) by using the 2.8-A resolution crystallographic coordinates as the starting conformation for understanding calcium ion-induced conformational changes that precede experimentally observable phospholipid binding. Simulations were performed on the non-metal-bound crystal structure, the form resulting from addition of eight calcium ions to the 1-65 region of the crystal structure, the form resulting from removal of calcium ions after 107 ps and continuing the simulation, and an isolated hexapeptide loop (residues 18-23). In all cases, the 100-ps time scale seemed adequate to sample an ensemble of solution conformers within a particular region of conformation space. The non-metal-containing BF1 did not unfold appreciably during a 106-ps simulation starting from the crystallographic geometry. The calcium ion-containing structure (Ca-BF1) underwent an interesting conformational reorganization during its evolution from the crystal structure: during the time course of a 107-ps simulation, Ca-BF1 experienced a trans----cis isomerization of the gamma-carboxyglutamic acid-21 (Gla-21)-Pro-22 peptide bond. Removal of the calcium ions from this structure followed by 114 ps of additional molecular dynamics showed significant unfolding relative to the final 20-ps average structure of the 107-ps simulation; however, the Gla-21-Pro-22 peptide bond remained cis. A 265-ps simulation on the termini-protected hexapeptide loop (Cys-18 to Cys-23) containing two calcium ions also did not undergo a trans----cis isomerization. It is believed that the necessary activation energy for the transitional event observed in the Ca-BF1 simulation was largely supplied by global conformational events with a possible assist from relief of intermolecular crystal packing forces. The presence of a Gla preceding Pro-22, the inclusion of Pro-22 in a highly strained loop structure, and the formation of two long-lived salt bridges prior to isomerization may all contribute to this finding.

Changing expectations: a longitudinal study of community attitudes toward a nuclear power plant.

Initial and 5-year follow-up interviews were conducted with 213 residents of the host community for a nuclear power plant. The purpose was to determine possible changes in attitudes toward the plant and expectations about potential outcomes associated with construction. Large negative changes in attitudes toward the plant were noted and were accompanied most notably by decreased expectations of positive outcomes. The structure of the expectations remained essentially stable over the 5-year period. Perceptions of hazards, community disruption, and economic benefits as measured early in construction and during peak construction were found to be the best predictors of acceptance of the nuclear plant. Initial expectations were found to predict overall attitude toward the plant 5 years later. Results were discussed in terms of implications for social impact assessment, large-scale community change, and the predictability of community attitudes toward nuclear power plant construction.