ABSTRACT
A new series of N-substituted dioxo-imidazo[3,4-c]thiazoles have been prepared and evaluated for their analgesic activity. The structures of these new derivatives were confirmed by lR, 1H NMR and 13C NMR spectra, and by elemental analysis. When administered intraperitoneally to mice all derivatives were devoid of any toxic effect, even at the high dose of 800 mg kg(-1). In the phenylbenzoquinone-induced abdominal constriction test in mice, eight of the nine synthesized compounds exhibited significant antinociceptive properties with ED50 values (50% effective dose) ranging from 46.7 to 104.7 mg kg(-1) intraperitoneally. Further investigation demonstrated that analgesic activity of the most effective derivatives 5e and 5f partly involved opioidergic and/or noradrenergic pathways.
Subject(s)
Analgesics/chemical synthesis , Thiazoles/chemical synthesis , Analgesics/chemistry , Analgesics/pharmacology , Animals , Benzoquinones/pharmacology , Drug Interactions , Injections, Intraperitoneal , Male , Mice , Structure-Activity Relationship , Thiazoles/chemistry , Thiazoles/pharmacology , Yohimbine/pharmacologyABSTRACT
The stability of morphine chlorhydrate injectable solutions with no preservative used for drug delivery system (PCA) was investigated. Many concentrations of morphine chlorhydrate were prepared using different solvents and in several containers: PCA cartridges and plastic syringes stored at 37 degrees C. Assays of drug substance and of degradation products were determined at different time within 14 days. In such conditions, morphine chlorhydrate solutions were stable: degradation products were quantitated less than the usual normal i.e. 2% of the theoric concentration of the drug.
