Automatic detection of cognitive impairment in patients with white matter hyperintensity and causal analysis of related factors using artificial intelligence of MRI.

PURPOSE: White matter hyperintensity (WMH) is a common feature of brain aging, often linked with cognitive decline and dementia. This study aimed to employ deep learning and radiomics to develop models for detecting cognitive impairment in WMH patients and to analyze the causal relationships among cognitive impairment and related factors. MATERIALS AND METHODS: A total of 79 WMH patients from hospital 1 were randomly divided into a training set (62 patients) and a testing set (17 patients). Additionally, 29 patients from hospital 2 were included as an independent testing set. All participants underwent formal neuropsychological assessments to determine cognitive status. Automated identification and segmentation of WMH were conducted using VB-net, with extraction of radiomics features from cortex, white matter, and nuclei. Four machine learning classifiers were trained on the training set and validated on the testing set to detect cognitive impairment. Model performances were evaluated and compared. Causal analyses were conducted among cortex, white matter, nuclei alterations, and cognitive impairment. RESULTS: Among the models, the logistic regression (LR) model based on white matter features demonstrated the highest performance, achieving an AUC of 0.819 in the external test dataset. Causal analyses indicated that age, education level, alterations in cortex, white matter, and nuclei were causal factors of cognitive impairment. CONCLUSION: The LR model based on white matter features exhibited high accuracy in detecting cognitive impairment in WMH patients. Furthermore, the possible causal relationships among alterations in cortex, white matter, nuclei, and cognitive impairment were elucidated.

Automatic diagnosis of Parkinson's disease using artificial intelligence base on routine T1-weighted MRI.

Background: Parkinson's disease (PD) is the second most common neurodegenerative disease. An objective diagnosis method is urgently needed in clinical practice. In this study, deep learning and radiomics techniques were studied to automatically diagnose PD from healthy controls (HCs). Methods: 155 PD patients and 154 HCs were randomly divided into a training set (246 patients) and a testing set (63 patients). The brain subregions identification and segmentation were automatically performed with a VB-net, and radiomics features of billateral thalamus, caudatum, putamen and pallidum were extracted. Five independent machine learning classifiers [Support Vector Machine (SVM), Stochastic gradient descent (SGD), random forest (RF), quadratic discriminant analysis (QDA) and decision tree (DT)] were trained on the training set, and validated on the testing. Delong test was used to compare the performance of different models. Results: Our VB-net could automatically identify and segment the brain into 109 regions. 2,264 radiomics features were automatically extracted from the billateral thalamus, caudatum, putamen or pallidum of each patient. After four step of features dimensionality reduction, Delong tests showed that the SVM model based on combined features had the best performance, with AUCs of 0.988 (95% CI: 0.979 ~ 0.998, specificity = 91.1%, sensitivity =100%, accuracy = 89.4% and precision = 88.2%) and 0.976 (95% CI: 0.942 ~ 1.000, specificity = 100%, sensitivity = 87.1%, accuracy = 93.5% and precision = 88.6%) in the training set and testing set, respectively. Decision curve analysis showed that the clinical benefit of the line graph model was high. Conclusion: The SVM model based on combined features could be used to diagnose PD with high accuracy. Our fully automatic model could rapidly process the MRI data and distinguish PD and HCs in one minute. It greatly improved the diagnostic efficiency and has a great potential value in clinical practice to help the early diagnosis of PD.

Prediction of single pulmonary nodule growth by CT radiomics and clinical features - a one-year follow-up study.

Background: With the development of imaging technology, an increasing number of pulmonary nodules have been found. Some pulmonary nodules may gradually grow and develop into lung cancer, while others may remain stable for many years. Accurately predicting the growth of pulmonary nodules in advance is of great clinical significance for early treatment. The purpose of this study was to establish a predictive model using radiomics and to study its value in predicting the growth of pulmonary nodules. Materials and methods: According to the inclusion and exclusion criteria, 228 pulmonary nodules in 228 subjects were included in the study. During the one-year follow-up, 69 nodules grew larger, and 159 nodules remained stable. All the nodules were randomly divided into the training group and validation group in a proportion of 7:3. For the training data set, the t test, Chi-square test and Fisher exact test were used to analyze the sex, age and nodule location of the growth group and stable group. Two radiologists independently delineated the ROIs of the nodules to extract the radiomics characteristics using Pyradiomics. After dimension reduction by the LASSO algorithm, logistic regression analysis was performed on age and ten selected radiological features, and a prediction model was established and tested in the validation group. SVM, RF, MLP and AdaBoost models were also established, and the prediction effect was evaluated by ROC analysis. Results: There was a significant difference in age between the growth group and the stable group (P < 0.05), but there was no significant difference in sex or nodule location (P > 0.05). The interclass correlation coefficients between the two observers were > 0.75. After dimension reduction by the LASSO algorithm, ten radiomic features were selected, including two shape-based features, one gray-level-cooccurence-matrix (GLCM), one first-order feature, one gray-level-run-length-matrix (GLRLM), three gray-level-dependence-matrix (GLDM) and two gray-level-size-zone-matrix (GLSZM). The logistic regression model combining age and radiomics features achieved an AUC of 0.87 and an accuracy of 0.82 in the training group and an AUC of 0.82 and an accuracy of 0.84 in the verification group for the prediction of nodule growth. For nonlinear models, in the training group, the AUCs of the SVM, RF, MLP and boost models were 0.95, 1.0, 1.0 and 1.0, respectively. In the validation group, the AUCs of the SVM, RF, MLP and boost models were 0.81, 0.77, 0.81, and 0.71, respectively. Conclusions: In this study, we established several machine learning models that can successfully predict the growth of pulmonary nodules within one year. The logistic regression model combining age and imaging parameters has the best accuracy and generalization. This model is very helpful for the early treatment of pulmonary nodules and has important clinical significance.