ABSTRACT
The seed extracts of Caesalpinia bonducella were subjected to screening of antidiabetic activity in alloxan induced hyperglycemia. The oral administration of the extracts (300 mg/kg) produced significant antihyperglycemic action as well as it lowered the BUN levels significantly. In the same study the action of the extracts on diabetes induced hyperlipidemia was analyzed where the extracts significantly lowered the elevated cholesterol as well as LDL level. The antihyperglycemic action of the extracts may be due to the blocking of glucose absorption. The drug has the potential to act as antidiabetic as well as antihyperlipidemic.
Subject(s)
Caesalpinia , Diabetes Mellitus, Experimental/prevention & control , Hypoglycemic Agents/pharmacology , Phytotherapy , Plant Extracts/pharmacology , Administration, Oral , Alloxan , Animals , Blood Glucose/drug effects , Blood Urea Nitrogen , Cholesterol/blood , Creatinine/blood , Diabetes Mellitus, Experimental/chemically induced , Female , Hypoglycemic Agents/administration & dosage , Hypoglycemic Agents/therapeutic use , Male , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Rats , Rats, Wistar , Seeds , Triglycerides/bloodABSTRACT
Caesalpinia bonduc Roxb. (Caesalpiniaceae) seed extracts were screened for adaptogenic activity using cold stress model and swim endurance model, the seed coat as well as kernel extracts showed significant antistress activity when administered orally at a dose of 300 mg/kg. The extracts significantly increased the swim endurance time. Stress induced animals exhibited hypoglycaemia as well as depletion in serum cortisol level and increased total leukocyte count, the extracts showed a significant action in overcoming these imbalances. It was also found that extracts proved efficient in controlling the hyperlipidaemic condition due to stress.
Subject(s)
Caesalpinia/chemistry , Plant Extracts/pharmacology , Seeds/chemistry , Adaptation, Physiological/drug effects , Animals , Blood Glucose/analysis , Cold Temperature , Female , Hydrocortisone/blood , Leukocyte Count , Lipids/blood , Male , Mice , Physical Endurance/drug effects , Physical Endurance/physiology , Plant Extracts/chemistry , Rats , Rats, Wistar , Stress, Physiological/physiopathology , Stress, Physiological/prevention & control , Swimming/physiologyABSTRACT
To evaluate the free radical scavenging activity of flavonoids containing extracts of Stevia leaf. Alcoholic. Successive butanolic and alcoholic extracts of leaves were examined for free radical scavenging activity using BHT (tert-butylhydroxytolune) as a positive control by in vitro models. Successive alcoholic extract showed remarkable free radical scavenging activity. The IC(50) was found to be 140 µg and 76 ig of successive alcoholic and BHT respectively in DPPH (2,2-diphenyl-1-picrylhydrazyl) assay method. The Dot-Blot test on silica layers also showed thescavenging activity of free radical of flavonoids containing extracts. The successive alcoholic extract shown significant antioxidant activity.