[Possibility of enzymatic lactate disintegration followed by formate production].

A possibility of lactate reverse desintegration to formate and acetaldehyde by lactate-synthase was established by the methods of enzymatic analysis, isotope indication, thin layer chromatography.

[Role of formic acid in transformation of acetic and succinic acids in animal tissues]. / Rol' murashynoï kysloty v peretvorenni otstovoï i iantarnoï kyslot u tkanynakh tvaryn.

Acetic and succinate acids KoA acyl derivatives interacting with formate were displayed to produce alpha-ketoacids--pyruvate and alpha-ketoglutarate. These acids also interact with formate and make pyruvic and malate acids, while alpha-ketoglutarate, evidently, tricarboxy acids. Interaction of formate with acetic and succinate acids inspite of occurring out of the tricarbone cycle increases the latter metabolic functions.

[Department of metabolism regulation. Biochemistry problems]. / Viddil rehuliatsiï ombinu rechovyn. Pro deiaki problemy biokhimiï.

The publication represents main results of investigations, performed at the Department of Metabolism Regulation in 1950-1995. The problems of protein biosynthesis, fixation and the regulatory role of carboxylic acid in heterotrophic organisms were studied. The role of formic acid in metabolism and changes in metabolic processes at chronic alcoholism were investigated as well. The fundamental results were used as a basis for the solution of practical questions of medicine and animal husbandry.

[Comparative characteristics of catalase from the fungus Penicillium vitale, which is synthesized under different nutritional conditions]. / Porivnial'na kharakterystyka katalazy z hryba Penicillium vitale, syntezovanoi za riznykh umov ioho kul'tyvuvannia

A comparative study of properties (absorption spectra, thermostability, pH optimum, polyacrylamide gel electrophoresis, DEAE-cellulose separation) and structure (amino acid composition, finger-prints, carbohydrate composition) was performed for P. vitale catalase synthesized under different medium conditions. In all cases the results were similar. The only difference occured in the amount of synthesized proteins. A conclusion is drawn that under different nourishing conditions of the fungus the properties and structure of the catalase are unchanged, but the regulatory mechanisms of catalase and glucosooxidate synthesis undergo changes.