ABSTRACT
BACKGROUND: There is significant data in the medical and surgical literature supporting the correlations between positive volume balance and negative outcomes such as AKI, prolonged mechanical ventilation, intensive care unit and hospital length of stay and increased mortality. METHODS: This single-center, retrospective chart review included adult patients identified from a Trauma Registry database. The primary outcome was the total ICU LOS. Secondary outcomes include hospital LOS, ventilator-free days, incidence of compartment syndrome, acute respiratory distress syndrome (ARDS), renal replacement therapy (RRT), and days of vasopressor therapy. RESULTS: In general, baseline characteristics were similar between groups with the exception of mechanism of injury, FAST exam, and disposition from the ED. The ICU LOS was shortest in the negative fluid balance and longest in the positive fluid balance group (4 days vs 6 days, P = .001). Hospital LOS was also shorter in the negative balance group than that of the positive balance group (7 days vs 12 days, P < .001). More patients in the positive balance group experienced acute respiratory distress syndrome compared to the negative balance group (6.3% vs 0%, P = .004). There was no significant difference in the incidence of renal replacement therapy, days of vasopressor therapy, or ventilator-free days. DISCUSSION: A negative fluid balance at seventy-two hours was associated with a shorter ICU and hospital LOS in critically ill trauma patients. Our observed correlation between positive volume balance and total ICU days merits further exploration with prospective, comparative studies of lower volume resuscitation to key physiologic endpoints compared with routine standard of care.
Subject(s)
Critical Illness , Respiratory Distress Syndrome , Adult , Humans , Retrospective Studies , Prospective Studies , Critical Illness/therapy , Length of Stay , Water-Electrolyte Balance , Intensive Care UnitsABSTRACT
Se determinó la prevalencia de anticuerpos antimaláricos, tipo IgG, mediante la técnica de inmunofluorescencia indirecta (IFI), en 392 sueros de donantes voluntarios de sangre del Hospital Universitario San Vicente de Paúl, recolectados durante los meses de septiembre y octubre del año 1995 y mantenidos en cogelación a -70ºC durante 36 meses. La prevalencia de seropositividad fue de 1,8 por ciento (7 donantes), de los cuales, tres tenían antecedentes de haber vivido en zona endémica para malaria; de éstos, dos habían sufrido malaria, por lo menos, una vez en la vida; los cuatro donantes restantes no habían vivido en zona endémica para la malaria ni tenían antecedentes de haberla padecido. Todos los donantes tuvieron gotas gruesas negativas para Plasmodium. Para tratar de reducir el riesgo de malaria transfusional, se recomienda informar en forma clara a los donantes sobre las áreas endémicas para malaria en el departamento, completar la encuesta que realizan los bancos de sangre con gota gruesa en todas la unidades de sangre que se vayan a transfundir y determinar anticuerpos antimaláricos en todos los donantes de riesgo con encuestas sospechosas y que puedan ser transmisores potenciales de Plasmodium
