Subject(s)
Epidermolysis Bullosa/genetics , Genetic Predisposition to Disease , Integrin alpha3/genetics , Lung Diseases, Interstitial/genetics , Mutation/genetics , Nephrotic Syndrome/genetics , DNA Mutational Analysis , Epidermolysis Bullosa/physiopathology , Humans , Infant , Lung Diseases, Interstitial/physiopathology , Male , Nephrotic Syndrome/physiopathology , Polymorphism, Single Nucleotide , RNA Splicing/geneticsABSTRACT
BACKGROUND: Scoliosis surgery in childhood is associated with a range of postoperative complications that may require admission to the pediatric intensive care unit (PICU) or high-dependency unit (HDU). AIM: The aim of this study was to identify preoperative factors associated with PICU and HDU admissions after corrective surgery and devise a scoring system that could be used by clinicians to predict the level of dependency required postoperatively. METHODS: A retrospective case note review was carried out in 90 patients who underwent corrective scoliosis surgery at Sheffield Children's Hospital (SCH) between January 2008 and October 2010. Predictors of PICU and HDU requirement postoperatively were identified and a simple scoring system created using multiple logistic regression and receiver operator characteristic (ROC). RESULTS: There was a statistically significant difference in the preoperative parameters (pulmonary function, Cobb angle, and number of vertebrae fused) of those patients who required PICU or HDU care compared with those who did not. The area under the receiver operator characteristic curve for the final scoring system was 0.95 for PICU admission and 0.87 for HDU admission at the optimal cut-off point, demonstrating good diagnostic accuracy. CONCLUSIONS: The authors have identified a significant relationship between preoperative variables and the levels of dependency required postoperatively and have proposed a scoring system which can be used to aid decision-making involving bed planning for patients after corrective scoliosis surgery. However, this work is based on the clinical course of a single set of patients who had surgery in a single tertiary center and has not been tested on patients from other centers.
Subject(s)
Orthopedic Procedures/adverse effects , Postoperative Complications/epidemiology , Scoliosis/surgery , Adolescent , Child , Child, Preschool , Female , Humans , Male , Postoperative Complications/diagnosis , Postoperative Complications/therapy , ROC Curve , Reproducibility of Results , Respiratory Function Tests , Retrospective Studies , Risk Factors , Spinal FusionABSTRACT
BACKGROUND: Extreme stress and inflammatory responses to open heart surgery are associated with increased morbidity and mortality. Based on both animal and adult human data, it was hypothesized that spinal anesthesia would be more effective at attenuating these responses than conventional high dose intravenous opioid techniques in infants and young children undergoing open heart surgery. METHODS: A prospective randomized controlled clinical trial was performed in 60 children aged up to 24 months undergoing open heart surgery. Patients were randomly assigned to receive either high-dose intravenous opioid or high-dose intravenous opioid plus spinal anesthesia. Spinal anesthesia was administered via an indwelling intrathecal catheter. RESULTS: Spinal anesthesia significantly reduced the stress responses as measured by plasma norepinephrine and epinephrine concentrations (both P < 0.05). Spinal anesthesia reduced plasma lactate concentrations (P < 0.05), but increased fluid requirements during the first postoperative day (P < 0.05). There were no differences in other cardiovascular parameters. CONCLUSIONS: Continuous spinal anesthesia reduces stress responses in infants and young children undergoing cardiac surgery with cardiopulmonary bypass more effectively than high-dose intravenous opioids alone.
Subject(s)
Anesthesia, Spinal , Cardiac Surgical Procedures/adverse effects , Catheterization , Stress, Physiological/prevention & control , Anesthesia, General , Anesthesia, Inhalation , Anesthesia, Intravenous , Anesthesia, Spinal/adverse effects , Biomarkers , Catecholamines/metabolism , Catheterization/adverse effects , Cytokines/metabolism , Double-Blind Method , Female , Hemodynamics/drug effects , Humans , Hydrocortisone/blood , Infant , Infant, Newborn , Inflammation/blood , Lactic Acid/blood , Male , Prospective Studies , Tumor Necrosis Factor-alpha/metabolismABSTRACT
A 12-year-old boy presented with an intracerebral haemorrhage secondary to Staphylococcus aureus endocarditis. He developed worsening aortic regurgitation and required aortic root replacement. In view of his recent haemorrhage, a heparin-bonded cardiopulmonary bypass circuit with low dose systemic heparinisation was used. No further intracerebral bleeding ensued and his neurological condition slowly improved.
