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1.
Article in English | MEDLINE | ID: mdl-24091404

ABSTRACT

Tree rearrangement operations typically induce a metric on the space of phylogenetic trees. One important property of these metrics is the size of the neighborhood, that is, the number of trees exactly one operation from a given tree. We present an exact expression for the size of the TBR (tree bisection and reconnection) neighborhood, thus answering a question first posed by Allen and Steel . In addition, we also obtain a characterization of the extremal trees whose TBR neighborhoods are maximized and minimized.


Subject(s)
Computational Biology/methods , Models, Genetic , Phylogeny
2.
Bull Math Biol ; 75(10): 1879-90, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23925727

ABSTRACT

Recently, we have shown that calculating the minimum-temporal-hybridization number for a set [Formula: see text] of rooted binary phylogenetic trees is NP-hard and have characterized this minimum number when [Formula: see text] consists of exactly two trees. In this paper, we give the first characterization of the problem for [Formula: see text] being arbitrarily large. The characterization is in terms of cherries and the existence of a particular type of sequence. Furthermore, in an online appendix to the paper, we show that this new characterization can be used to show that computing the minimum-temporal hybridization number for two trees is fixed-parameter tractable.


Subject(s)
Models, Genetic , Phylogeny , Algorithms , Computational Biology , Hybridization, Genetic , Mathematical Concepts
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