ABSTRACT
<b>Background and Objective:</b> <i>Hippocampus kuda</i> and ginseng are commonly known for male sexual function mainly for their potency and libido enhancement effects, however, no study was reported that incorporates these fluids. This study aimed at the extraction of these two ingredients to understand the synergistic effect of increasing testosterone content and semen quality was studied in this article. <b>Materials and Methods:</b> After extracting and creating extracts of <i>Hippocampus kuda</i> and ginseng, a 1:1 extract was mixed to create a mixture of both ingredients. <b>Results:</b> The results obtained from this study confirmed that alcohol extracts from <i>Hippocampus kuda</i> and Panax ginseng have a positive effect on testosterone content and semen quality. In particular, the combination of extracts from these two ingredients significantly improves testosterone content and semen quality compared with using extracts separately. <b>Conclusion:</b> High-extract mixture extracted by alcohol from <i>Hippocampus kuda</i> and Panax ginseng at the rate of 1/1 showed a superior effect in increasing testosterone content and semen quality compared to the extract of each material. A high extract mixture used at a dosage of 240 mg/100 g body weight/day is suitable for increasing the testosterone content, increasing sperm density, increasing the survival rate of spermatozoa and reducing the rate of malformed sperm in real rats experience.
Subject(s)
Panax , Smegmamorpha , Animals , Male , Plant Extracts/pharmacology , Rats , Seeds , Semen Analysis , TestosteroneABSTRACT
Classical swine fever virus (CSFV) strains ND20 and HY78 were detected from infected pigs in the Xuan Truong-Nam Dinh and Hung Yen provinces in North Vietnam in 2014 and 2015, respectively. The most prevalent CSFV subgenotypes in Vietnam are 2.1 and 2.2, and these two complete genome sequences will help the CSFV prevention policy in Vietnam. In particular, subgenotype 2.2 (ND20 strain) has been reported less worldwide, so it is worth sharing information about this subgenotype.
ABSTRACT
The selective expression of CD137 on cells of the immune system (e.g., T and DC cells) and oncogenic cells in several types of cancer leads this molecule to be an attractive target to discover cancer immunotherapy. Therefore, specific antibodies against CD137 are being studied and developed aiming to activate and enhance anti-cancer immune responses as well as suppress oncogenic cells. Accumulating evidence suggests that anti-CD137 antibodies can be used separately to prevent tumor in some cases, while in other cases, these antibodies need to be co-administered with other antibodies or drugs/vaccines/regents for a better performance. Thus, in this work, we aim to update and discuss current knowledge about anti-cancer effects of anti-CD137 antibodies as mono- and combined-immunotherapies.
Subject(s)
Antineoplastic Agents, Immunological/therapeutic use , Molecular Targeted Therapy , Neoplasms/drug therapy , Tumor Necrosis Factor Receptor Superfamily, Member 9/antagonists & inhibitors , Animals , Antineoplastic Agents, Immunological/pharmacology , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biomarkers , Combined Modality Therapy , Humans , Immunotherapy , Molecular Targeted Therapy/adverse effects , Molecular Targeted Therapy/methods , Neoplasms/immunology , Neoplasms/metabolism , Treatment Outcome , Tumor Necrosis Factor Receptor Superfamily, Member 9/agonists , Tumor Necrosis Factor Receptor Superfamily, Member 9/metabolismABSTRACT
Objective: To assess the effectiveness of extra-curricular activities in improving reproductive health knowledge of ethnic minority students in mountainous areas in Vietnam. Materials and methods: The study was conducted on 400 ethnic minority students at Dien Bien Dong Ethnic Minority High School in Vietnam. The selected healthy students with a similar mix of study results and grades were divided into two groups: a control group had no the extra-curricular activities on reproductive health, and an experimental group participated extra-curricular activities on reproductive health. The extra-curricular activities were designed as a series of seminars on numerous reproductive health contents. The retention of reproductive health knowledge was then evaluated by a test containing multiple-choice and single-choice questions. Results: Results showed that the percentage of students who did not correctly understand puberty signs, ovulation time during menstrual cycle, contraceptive method use and sexually transmitted diseases in the control group ranged from 34.5% - 83.5%. Despite the fact that the ethnic minority high school students' knowledge of reproductive health was poor, the percentage of students who fully understood puberty signs, ovulation time during menstrual cycle, contraceptive method use and sexually transmitted diseases significantly increased and reached at least 90% after attending extra-curricular activities on reproductive health (p < 0.05). Conclusion: The ethnic minority high school students' knowledge of reproductive health was relatively poor. Extra-curricular activities markedly increased the knowledge of many reproductive health aspects. These findings suggest that it is necessary to improve the knowledge of reproductive health for ethnic minority high school students in mountainous areas in Vietnam, and that extra-curricular activities organized as seminars are effective and suitable to provide and retain students' knowledge of reproductive health.
