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Acta Biochim Biophys Sin (Shanghai) ; 36(1): 1-10, 2004 Jan.
Article in English | MEDLINE | ID: mdl-14732867

ABSTRACT

Stepping acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) as another type of disease has been threatening mankind since late last year. Many scientists worldwide are making great efforts to study the etiology of this disease with different approaches. 13 species of SARS virus have been sequenced. However, most people still largely rely on the traditional methods with some disadvantages. In this work, we used Wolfram approach to study the relationship among SARS viruses and between SARS viruses and other types of viruses, the effect of variations on the whole genome and the advantages in the analysis of SARS based on this novel approach. As a result, the similarities between SARS viruses and other coronaviruses are not really higher than those between SARS viruses and non-coronaviruses.


Subject(s)
Gene Expression Profiling/methods , Gene Expression Regulation, Viral/genetics , Models, Genetic , Sequence Alignment/methods , Sequence Analysis, DNA/methods , Severe acute respiratory syndrome-related coronavirus/classification , Severe acute respiratory syndrome-related coronavirus/genetics , Algorithms , Computer Simulation , Databases, Genetic , Humans , Sequence Homology, Nucleic Acid
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