ABSTRACT
Objective To study the curative effect and adverse drug reactions of lentinan combination with chemotherapy in the treatment of advanced gastric cancer.Methods 115 eases of advanced gastric cancer patients are divided to treatment group and control group randomly.57 pafients in control group ale treated with the chemotherapy rcglment:L-OHP combination with FT-207 and CF,58 patients in treatment group are treated with the chemotherapy regiment:L-OHP combination with FT-207 and CF,cooperating with the synthetical treatment with lenfinan and vitamin B12,folic acid and so on.Results The control group:there are 18 cases get PR,the total effective rate is 31.6%,TTP is 3.1 months,MST is 5.5 months,the rate of survival in first year and second years is 56.1%and 22.8% respectively.The treatment group:there are l case get CR and 29 cases get PR,the total effective rate is 51%,TTP is 4.5 months.MST iS 9.8 months,the rote of survival in first year and second years is 81.1%and 51.7%respectively.There is statistieall difference between these two groups(P＜0.05).The main adverse drug reactions of two groups are restraint of marrow and gastrointestinal reactions.there is statistical difiefence in the decrease of HbO2 and the rate of occurrence of buecal inflammation between these two groups.Conclusion The method of lentinan combination with chemotherapy in the synthetical treatment of advanced gastric cancer has high effective rate and small adverse drug reactions.It is worth of being popularized.
