Subject(s)
COVID-19 , SARS-CoV-2 , Antibody Formation , COVID-19 Vaccines , Humans , Immunologic Factors , VaccinationSubject(s)
COVID-19/epidemiology , Dermatology/organization & administration , Health Services Accessibility , Physical Distancing , SARS-CoV-2 , Adolescent , Adult , Aged , Aged, 80 and over , COVID-19/prevention & control , COVID-19/transmission , Female , Humans , Male , Middle Aged , Surveys and Questionnaires , United Kingdom , Young AdultSubject(s)
Coronavirus Infections/prevention & control , Pandemics/prevention & control , Patient Acceptance of Health Care/statistics & numerical data , Pneumonia, Viral/prevention & control , Referral and Consultation/statistics & numerical data , Skin Neoplasms/epidemiology , State Medicine/statistics & numerical data , Betacoronavirus/isolation & purification , COVID-19 , Coronavirus Infections/epidemiology , Coronavirus Infections/transmission , Coronavirus Infections/virology , Humans , Infection Control/standards , Pneumonia, Viral/epidemiology , Pneumonia, Viral/transmission , Pneumonia, Viral/virology , Referral and Consultation/standards , Referral and Consultation/trends , SARS-CoV-2 , Skin Neoplasms/diagnosis , United Kingdom/epidemiologySubject(s)
Receptors, N-Methyl-D-Aspartate/metabolism , Skin/metabolism , Stress, Psychological/metabolism , Acute Disease , Adult , Double-Blind Method , Female , Gene Expression , Healthy Volunteers , Humans , Male , Pilot Projects , Protein Array Analysis/methods , Receptors, N-Methyl-D-Aspartate/genetics , Stress, Psychological/geneticsSubject(s)
Encephalitis/etiology , Psoriasis/complications , Adolescent , Adult , Carbon Radioisotopes/metabolism , Chronic Disease , Encephalitis/diagnosis , Female , Humans , Isoquinolines/metabolism , Magnetic Resonance Imaging/methods , Male , Middle Aged , Positron-Emission Tomography/methods , Young AdultABSTRACT
Dermatologists are only too aware of the significant role psychosocial stress plays in the exacerbation of skin disease; indeed, it is often the first precipitant patients mention when they attend outpatient clinics. Of late, research has focused on understanding the 'brain-skin' axis, a complex interplay between the nervous and immune systems and the skin. In particular, there is an evolving body of literature exploring the underlying pathophysiological mechanisms by which psychosocial stress influences skin homeostasis. This article provides a broad overview of the literature, emphasizing the importance of individual stress perception and summarizing the varied roles of the major cutaneous stress-response pathways. Both central [the hypothalamic-pituitary-adrenal (HPA) axis and the locus ceruleus-norepinephrine (LC-NE) sympathetic adrenomedullary system] and peripheral (the intracutaneous HPA axis and the release of mediators from peripheral sensory and autonomic nerves) pathways are discussed. Moreover, how activation of these pathways affects the skin's immune system, barrier function, wound healing and susceptibility to infection is reviewed. Although this field of research is rapidly expanding, several important questions remain unanswered, including: what is the precise role of mast cells in the cutaneous stress response?; what is the role of regulatory T-cells?; can therapeutic intervention be harnessed to prevent the stress-induced exacerbation of skin disease? It is anticipated that an improved understanding of the underlying mechanisms through which psychosocial stress affects the homeostasis of healthy skin will not only increase knowledge of the brain-skin axis but will also improve the holistic management of stress-responsive cutaneous disease.
Subject(s)
Skin Diseases/psychology , Skin Physiological Phenomena , Stress, Psychological/complications , Sympathetic Nervous System/physiology , Humans , Hypothalamo-Hypophyseal System/physiology , Immunity, Cellular/physiology , Pituitary-Adrenal System/physiology , Skin/immunology , Skin/innervation , Skin Diseases/immunology , Skin Diseases/physiopathology , Stress, Psychological/physiopathology , Wound Healing/physiologyABSTRACT
It is widely accepted that psychosocial stress can result from the daily strains of living with a diagnosis of psoriasis. There is now an evolving body of work to suggest that psychosocial stress may also play a role in the exacerbation of psoriasis. We discuss the historical evidence supporting a temporal relationship between psychosocial stress and the exacerbation of psoriasis. The underlying pathophysiological mechanisms by which this occurs are largely unknown, but current evidence points towards a role for nerve-related factors, namely their interaction with mast cells and the potentiation of neurogenic inflammation in this regard. It is also likely that the physiological stress response in patients with psoriasis differs from that in healthy individuals, as evidenced by alterations in the hypothalamic-pituitary-adrenal axis and sympathetic-adrenal-medullary system function. Psychological stress results in a redistribution of leucocytes with increased trafficking of inflammatory cells into the skin, which may exacerbate psoriasis. Langerhans cells play a role in the stress response of normal skin; their function in the stress response of patients with psoriasis is open to speculation. We discuss the influence of stress reactivity in patients with psoriasis and the impact of stress reduction strategies in the management of psoriasis. Finally, we suggest potentially fruitful areas for future research.