ABSTRACT
CT scanning of the thyroid following oral administration of potassium iodate was performed on two sisters in whom raised calcitonin levels had been found at a pentagastrin stimulation test undertaken to screen for medullary carcinoma of the thyroid. Three histologically proven, clinically occult C-cell carcinomas measuring 2 mm or less were detected by CT scanning. This technique may be useful prior to surgery in patients in whom medullary carcinoma of the thyroid is suspected but not proven.
Subject(s)
Carcinoma/diagnostic imaging , Multiple Endocrine Neoplasia/diagnostic imaging , Thyroid Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Adolescent , Adult , Calcitonin/blood , Carcinoma/surgery , Humans , Male , Multiple Endocrine Neoplasia/genetics , Pentagastrin , Thyroid Neoplasms/blood , Thyroid Neoplasms/genetics , Thyroid Neoplasms/surgeryABSTRACT
Thirteen patients have been immunized with their own irradiated melanoma cells on one or more occasions. Following these autografts tumour-specific cytotoxic antibodies were produced, the longest response lasting 14 days. This procedure had no apparent effect on the course of the disease in these patients.
