ABSTRACT
Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor. We report here a remarkable degree of insulin resistance in a patient with adult respiratory distress syndrome and myelodysplasia.
Subject(s)
Enzyme Inhibitors/pharmacology , Insulin Resistance , Myelodysplastic Syndromes/metabolism , Topotecan/pharmacology , Tumor Necrosis Factor-alpha/physiology , Aged , Humans , Male , Time Factors , Tumor Necrosis Factor-alpha/antagonists & inhibitorsABSTRACT
Twenty-nine patients treated with adjuvant chemotherapy for carcinoma of the breast were evaluated for frequency and amount of weight gained during treatment. No difference with respect to age, menopausal status, estrogen receptor status, nodal status, biochemical parameters, or treatment regimen (CMF versus CMFVP) were seen. The gain in weight seen in some 50% of the patients treated seems to be a function of a decrease in activity level during treatment.