ABSTRACT
Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free "green" post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.
Subject(s)
Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Drug Delivery Systems , Animals , COS Cells , Chlorocebus aethiops , HeLa Cells , Humans , Nanoparticles , Tissue DistributionABSTRACT
Recently, a debate has arisen over which of the two distinct parts of the Fermi surface of Sr(2)RuO(4) is the active part for the chiral p-wave superconductivity exhibited. Early theories proposed p-wave pairing on the two-dimensional γ band, whereas a recent proposal focuses on the one-dimensional (α, ß) bands whose nesting pockets are the source of the strong incommensurate spin density wave (SDW) fluctuations. We apply a renormalization group theory to study quasi-one-dimensional repulsive Hubbard chains and explain the form of SDW fluctuations, reconciling the absence of long-range order with their nesting Fermi surface. The mutual exclusion of p-wave pairing and SDW fluctuations in repulsive Hubbard chains favors the assignment of the two-dimensional γ band as the source of p-wave pairing.
ABSTRACT
By using Bogoliubov-de Gennes equations, we study superconducting (SC) states in a quasi-two-dimensional system of radius R. It is shown that no vortices exist in s-wave SC samples with R < R(c) ~ ξ(0), the T = 0 coherence length. We predict that chiral p-wave states exhibit superconductivity for R < R(c) only in the presence of a vortex with opposite chirality. This induced SC phase is a consequence of nonzero chirality of the pairing order parameter and implies the presence of chiral edge currents. Our study may be applied to sharply probing the pairing symmetry of unconventional superconductors.
