ABSTRACT
AIMS: The study evaluated the relationship between cardiovascular risk factors (CRF), gene polymorphism, calcification and fibrosis of stenotic aortic valves. METHODS AND RESULTS: The calcium content of 187 excised stenotic aortic valves was determined using atomic absorption spectroscopy. Hydroxyproline content was quantified. Left-heart catheterization was performed. CRF and genotypes of the interleukin 10, connective tissue growth factor (CTGF) and chemokine receptor 5 (CCR5) polymorphisms were assessed. Calcification consisted of Ca-deficient hexagonal hydroxyapatite, Ca(10 - x)(HPO4)x(PO4)(6 - x)(OH)(2 - x); with 0Subject(s)
Aortic Valve Stenosis/metabolism
, Aortic Valve/metabolism
, Calcinosis/metabolism
, Durapatite/analysis
, Aged
, Aortic Valve Stenosis/genetics
, Calcinosis/genetics
, Crystallization
, Female
, Fibrosis
, Gene Frequency
, Genotype
, Humans
, Hydroxyproline/analysis
, Male
, Risk Factors
, Sex Factors
, Spectrophotometry, Atomic