Using behavior to determine immature life-stages in captive western gorillas.

Ontogenic development is divided into infant, juvenile, adolescent and adult life-stages. Although the developmental trajectory of an individual is a flexible entity, which differs within species, environment and sex, life-stage classifications are generally structured, age-based systems. This invariably leads to rigidity within a dynamic system and consequently hampers our understanding of primate life history strategies. We propose that life-stage classifications should be quantitative, flexible entities, which use a reliable measurement of development. Here, we provide a methodological example where placement into a life-stage is based upon behavioral variance between other similar-aged individuals. Behavioral data were collected from 12 male (3-11 years old) and 9 female (3-8 years old) captive immature western gorillas (Gorilla gorilla gorilla) housed in five family groups, using continuous focal sampling; 900 hr of data were collected over 131 days. Data were applied to four published life-stage classifications for mountain gorillas (Gorilla beringei beringei), which showed variable ability to determine life-stage in western gorillas. A new life-stage classification (Hutchinson & Fletcher) was proposed specifically for western gorillas, whereby multiple co-varying behavior provided a robust measure of linear development across immaturity. Each life-stage was found to be a distinct ontogenic phase and the classification discriminated life-stage with a high level of accuracy. Using the Hutchinson & Fletcher classification we provide evidence for disparity in developmental trajectories between the sexes from the juvenile period onwards. To expand the understanding of primate life histories, we propose that flexible classifications should be used to enable comparison of allometric life history traits within and between species, from birth onwards.

Cortical layer III pyramidal dendritic morphology normalizes within 3 weeks after kindling and is dissociated from kindling-induced potentiation.

This experiment examined the effect of a 3-week rest after electrical kindling on kindling-induced potentiation and the morphology of frontal (Fr1) neocortical layer III pyramidal cell dendrites in both male and female rats. Repeated elicitation of afterdischarge resulted in an increase in the severity of the behavioural seizures and afterdischarge duration. The late component of the transcallosal evoked responses was significantly larger 1 and 21 days following the last kindling session in both male and female rats. Analysis of the Golgi-Cox impregnated pyramidal cell dendrites indicated no significant difference in the amount of apical and basilar dendritic, branching, length, and spine density in both male and female rats, relative to their respective control groups, 21 days following the last kindling session. There was, however, one exception, the male group showed a significant increase in apical spine density. The persistent expression of kindling-induced potentiation appears to be dissociated from the renormalized pyramidal cell dendritic morphology.

Sex differences in cortical plasticity and behavior following anterior cortical kindling in rats.

This experiment examined the effect of electrical kindling on the morphology of frontal (Fr1) neocortical layer III pyramidal cell dendrites in both male and female rats. Repeated elicitation of afterdischarge resulted in an increase in the severity of the behavioural seizures and an increase in afterdischarge duration, frequency and amplitude in all rats. The late component of the transcallosal evoked responses also increased following both 7 and 25 kindling sessions in male rats and following 25 kindling sessions in female rats. Analysis of the Golgi-Cox impregnated pyramidal cell dendrites indicated a significant decrease in the amount of apical and basilar dendritic spine density, length and branching in female rats following 7 days, but not 25 days, of kindling. Male rats had significantly lower apical and basilar dendritic spine density and branching measures following 25 days, but not 7 days, of kindling, as well as significantly lower apical and basilar dendritic length following 7 days of kindling. The differential gender effect suggests that males and females recruit similar plastic mechanisms although at different times in response to electrical kindling.

Experience of a standardised method for assessing respiratory disability.

A standardised method of scoring respiratory disability based on measurement and/or estimation of maximal oxygen uptake has recently been developed by the European Society for Clinical Respiratory Physiology. In the present study, we wanted to determine how the results obtained using this objective method compared with those by the more traditional empirical method used in a Medical Boarding Centre (MBC) for Respiratory Diseases. The subjects were 62 men who were claiming industrial injuries benefit on account of prior exposure to a respiratory hazard. The MBC ratings and the disability scores were correlated and, in the case of men with moderate or severe disability, numerically equivalent. The results provided independent confirmation that the MBC ratings were influenced by the forced expiratory volume, radiological category of pneumoconiosis and grade of breathlessness. In subjects in whom the measured and estimated maximal oxygen uptakes were inconsistent, the information obtained during the exercise test could identify which of several factors contributed to the exercise limitation. Since the new method might be expected to reduce the difficulties experienced in assessing respiratory disability, its use is recommended.

Mitral valvuloplasty and repair for infective endocarditis.

The traditional therapy for acute bacterial endocarditis of the mitral valve refractory to medical treatment is valve replacement. Successful valvuloplasty may be feasible in selected cases, in which the infection is limited to a small portion of the mitral valve anulus. The following report describes a case in which valvuloplasty with excision of the affected valve was performed successfully with no recurrence of infection over a 3-year follow-up period.

Laceration of a mitral papillary muscle and the aortic root as a result of blunt trauma to the chest. Case report and review of the literature.

A case is presented of a steering wheel injury to the chest, in which the initial clue to significant cardiac injury was a new murmur and abnormal electrocardiogram. Precise preoperative echocardiographic evaluation revealed a combination of injuries consisting of (1) mitral incompetence secondary to partial laceration of a papillary muscle, (2) circumferential laceration of the aortic root contained by the adventitia, and (3) rupture of the pericardium. Operative correction of the mitral and aortic root lesions was performed 9 days after the injury. Twelve other cases of successful surgical correction of traumatic mitral incompetence are reviewed and compared.

Post-milking iodine teat skin disinfectants. I. Bactericidal efficacy.

An iodine teat skin disinfectant tested in lactating cows over a range of concentrations, 100 to 10 000 mg available iodine/l(mgavI/l) was found bactericidally effective against Staphylococcus aureus when containing 1000 mg avI/l or greater. Against Streptococcus dysgalactiae 5000 mg avI/l or greater was bactericidally effective. The addition of glycerine to a disinfectant containing 5000 or 1000 mg avI/l at levels of 225 ml/l and 105 ml/l, respectively, resulted in a reduction in bactericidal efficacy of the disinfectant. Emulsified paraffin added at concentrations of between 50 and 500 ml/l had no effect on the efficacy of the 5000 mg avI/l disinfectant, but the addition of 200 ml/l emulsified paraffin to a 1000 mg avI/l disinfectant significantly reduced its efficiency. Iodine disinfectants containing emulsified paraffin phase separated rapidly during storage, and the bactericidal efficacy of the phases differed significantly and diminished with time.

Aortocoronary bypass surgery: a 7-year follow-up.

Follow-up of 748 consecutive patients who underwent aortocoronary artery bypass grafts was obtained for 5 to 94 months (average, 59 months). Operative mortality of 2.5% did not vary with number of vessels bypassed. There was a linear 3.5% annual recurrence rate of angina, and average annual late infarction rate of 1.4%. The cumulative survival rates did not differ for the number of grafts performed or for men and women, but did differ for left main coronary stenosis and impaired ejection fractions. The late cumulative survival rates for the entire group approached those of the general U.S. population.

Combined left ventricular aneurysm and coronary artery bypass surgery: long-term results of 100 consecutive patients.

Forty-four percent of 2,367 patients who had operations for the complications of coronary atherosclerosis between 1971 and 1977 were noted to have major left ventricular wall motion abnormalities. Of this group, 100 patients required left ventricular aneurysm resections or plications (4.2%). There were 85 men and 15 women. Their average age was 52 years (range, 30 to 68 years). Concomitant coronary artery bypass grafting was required in 95 patients. The operative mortality was 7% and the actuarial survival at six years was 78%. Patients were followed for an average of 31 months (range, 3 to 72 months). Eighty-eight percent of the survivors had excellent or good results with improvement of their functional status to the New York Heart Association classes I and II. Age, congestive heart failure, and poor residual left ventricular function had an adverse effect on the outcome of these patients. Concomitant coronary artery bypass grafting seems to have favorably influenced their outcome and functional recovery. Surgical judgment is of great importance in selecting which patients require left ventricular aneurysm resection.

Penetrating cardiac trauma. Experience with thirty-four patients in a hospital without cardiopulmonary bypass capability.

A review of thirty-four consecutive penetrating wounds of the heart is presented. Thirty-one patients were in shock at the time of admission, and fourteen had no obtainable blood pressure and were comatose or moribund. The weapon used, clinical status of the patient on arrival, size of the cardiac wound, and presence of associated injuries affected the mortality rate. Seven of the eight deaths were considered unpreventable due to clinical deterioration by the time of arrival. Clinical recognition of cardiac tamponade is stressed. Early open thoracotomy and closure of the cardiac wound is advocated as the preferred method of treating this injury. No patient was lost due to lack of cardiopulmonary bypass capability.