Enhancing Campus Safety: Exploring Student Perspectives on a Text Message-Delivered Intervention for Addressing Sexual Violence and Alcohol Use.

BACKGROUND: Alcohol-related sexual violence, including sexual coercion, nonconsensual contact, and rape, is prevalent on college campuses. AIM: The purpose of the study was to investigate college students' feedback and recommendations regarding content for a text-message-delivered harm reduction intervention to jointly address alcohol use and alcohol's role in sexual violence risk. METHODS: This qualitative thematic study used focus groups and individual interviews to collect feedback from 61 college students between February 2019 and July 2020. RESULTS: Targeted recruitment resulted in a sample that was nearly half queer/ lesbian, gay, bisexual (46.2%) or trans* (9.8%) identified students. Participants endorsed text messaging as an effective way to reach college students but diverged in specific content they felt was relevant and appropriate for a universal education intervention. Students preferred content describing individual strategies versus those requiring collaboration from friends or potential sex partners. Students also preferred content phrased as suggestions or questions versus declarative statements. Although most participants recognized the value of content related to consent, sexual violence, sexual health, and resources, a few male-identifying participants failed to recognize that content as important to their experience. Maintaining brevity while discussing consent in the overlapping settings of drinking and interpersonal relationships was described as a particular challenge. IMPACT OF THIS WORK ON CAMPUS SEXUAL ASSAULT AND FORENSIC NURSING: Students in our sample highlighted the challenges of sharing sexual violence and alcohol-related harm reduction text messaging because of the complexities of rape culture, consent, and interpersonal dynamics during college student drinking events.

A comprehensive study to delineate the role of an extracellular vesicle-associated microRNA-29a in chronic methamphetamine use disorder.

Extracellular vesicles (EVs), which express a repertoire of cargo molecules (cf. proteins, microRNA, lipids, etc.), have been garnering a prominent role in the modulation of several cellular processes. Here, using both non-human primate and rodent model systems, we provide evidence that brain-derived EV (BDE) miRNA, miR-29a-3p (mir-29a), is significantly increased during chronic methamphetamine (MA) exposure. Further, miR-29a levels show significant increase both with drug-seeking and reinstatement in a rat MA self-administration model. We also show that EV-associated miR-29a is enriched in EV pool comprising of small EVs and exomeres and further plays a critical role in MA-induced inflammation and synaptodendritic damage. Furthermore, treatment with the anti-inflammatory drug ibudilast (AV411), which is known to reduce MA relapse, decreased the expression of miR-29a and subsequently attenuated inflammation and rescued synaptodendritic injury. Finally, using plasma from MUD subjects, we provide translational evidence that EV-miR29a could potentially serve as a biomarker to detect neuronal damage in humans diagnosed with MA use disorder (MUD). In summary, our work suggests that EV-associated miR-29a-3p plays a crucial role in MUD and might be used as a potential blood-based biomarker for detecting chronic inflammation and synaptic damage.

Hybrid nanorod-polymer solar cells.

We demonstrate that semiconductor nanorods can be used to fabricate readily processed and efficient hybrid solar cells together with polymers. By controlling nanorod length, we can change the distance on which electrons are transported directly through the thin film device. Tuning the band gap by altering the nanorod radius enabled us to optimize the overlap between the absorption spectrum of the cell and the solar emission spectrum. A photovoltaic device consisting of 7-nanometer by 60-nanometer CdSe nanorods and the conjugated polymer poly-3(hexylthiophene) was assembled from solution with an external quantum efficiency of over 54% and a monochromatic power conversion efficiency of 6.9% under 0.1 milliwatt per square centimeter illumination at 515 nanometers. Under Air Mass (A.M.) 1.5 Global solar conditions, we obtained a power conversion efficiency of 1.7%.