Gadolinium-Based Magnetic Resonance Theranostic Agent with Gallic Acid as an Anti-Neuroinflammatory and Antioxidant Agent.

Studies in the field have actively pursued the incorporation of diverse biological functionalities into gadolinium-based contrast agents, aiming at the amalgamation of MRI imaging and therapeutic capabilities. In this research, we present the development of Gd-Ga, an anti-neuroinflammatory MR contrast agent strategically designed to target inflammatory mediators for comprehensive imaging diagnosis and targeted lesion treatment. Gd-Ga is a gadolinium complex composed of 1,4,7-tris(carboxymethylaza)cyclododecane-10-azaacetylamide (DO3A) conjugated with gallic acid (3,4,5-trihydroxybenzoic acid). Upon intravenous administration in LPS-induced mouse models, Gd-Ga demonstrated a remarkable three-fold increase in signal-to-noise (SNR) variation compared to Gd-DOTA, particularly evident in both the cortex and hippocampus 30 min post-MR monitoring. In-depth investigations, both in vitro and in vivo, into the anti-neuroinflammatory properties of Gd-Ga revealed significantly reduced protein expression levels of pro-inflammatory mediators compared to the LPS group. The alignment between in silico predictions and phantom studies indicates that Gd-Ga acts as an anti-neuroinflammatory agent by directly binding to MD2. Additionally, the robust antioxidant activity of Gd-Ga was confirmed by its effective scavenging of NO and ROS. Our collective findings emphasize the immense potential of this theranostic complex, where a polyphenol serves as an anti-inflammatory drug, presenting an exceptionally efficient platform for the diagnosis and treatment of neuroinflammation.

The effect of backpack weight on the performance of basic short-term/working memory tasks while walking along a pre-determined route.

This study investigated possible backpack weight effects on the performance of three basic short-term/working memory (STM/WM) tasks conducted concurrently with the physical task of route walking. The STM/WM tasks were the Corsi block-tapping, digit span, and 3-back tasks, and, were employed to examine the visuo-spatial sketchpad, phonological loop and central executive components of the WM system. Four backpack weight levels (0%, 15%, 25% and 40% of body mass) were considered. Thirty participants conducted the three experimental tasks requiring physical-cognitive multitasking. Data analyses revealed that: (1) increased backpack weight resulted in decreases in the performance of the Corsi block-tapping and the 3-back task, but (2) backpack weight did not significantly affect the digit span task performance. The study results suggest that reducing backpack weight could benefit the performance of various cognitive tasks during route walking. The study findings may be useful for the ergonomics design of body-worn equipment and human-system interfaces.Practitioner summary: This study examined the backpack weight effects on the performance of three basic short-term/working memory tasks conducted concurrently with the physical task of route walking. The study revealed that reducing backpack weight could benefit various cognitive tasks during physical-cognitive multitasking, especially cognitive tasks that require visuospatial processing and executive control.

Severe obesity effect on low back biomechanical stress of manual load lifting.

BACKGROUND: Little research is available on low back biomechanical stresses that obese and overweight workers experience from manual load lifting. OBJECTIVE: The study objective was to quantitatively evaluate low back biomechanical stresses of severely obese (BMI≥35 kg/m2) workers during manual lifts of moderate load weights. METHOD: Twenty severely obese and 20 normal weight participants performed infrequent lifting in 16 task conditions. In each task condition, NIOSH recommended load weights were computed for the origin and destination of lift and were employed as the load weights. Optical motion capture was performed to collect lifting posture data. For each participant and each lifting condition, L5/S1 disc compression forces were computed at the origin and destination of lift using a static low back biomechanical model. RESULTS: The L5/S1 disc compression forces estimated for the severely obese participants ranged from 3000N to 8500N and many exceeded the 3400N NIOSH action limit by large margins. Group mean disc compression force was significantly larger for the severely obese than the normal weight group. CONCLUSION: In light of previous research on spine, bone and obesity, the study results seem to suggest that severely obese individuals are likely at an increased risk of lifting-related low back pain compared with normal weight individuals.