ABSTRACT
A very rare clinical entity, so-called eosinophilic meningitis, classified by prevalence of eosinophils in cerebrospinal fluid (CSF), with the presence of pleiocytosis, has been recorded in our laboratory four times only in the last 24 years. A low glucose level, elevation of total protein and lactic acid in CSF were detected in all the clinical cases. The last two cases were made possible by using flow cytometry method; surprisingly, the presence was found in mature T-cells in CSF, predominantly helpers (CD3+, CD4+) and, practically, none is B-cells (CD19+), plasma cells (CD138+) and NK-cells.
Subject(s)
Eosinophils/immunology , Meningitis/cerebrospinal fluid , Meningitis/immunology , Blood Proteins/cerebrospinal fluid , Flow Cytometry , Glucose/cerebrospinal fluid , Humans , Lactic Acid/cerebrospinal fluid , Leukocyte Count , Meningitis/diagnosis , T-Lymphocytes/immunology , T-Lymphocytes, Helper-Inducer/immunologyABSTRACT
A routine diagnostic procedure of cryptococcal meningitis using Alcian Blue and Nuclear Fast Red staining is described in a group of 16 patients. Cerebrospinal fluid findings, including clinical cytology, routine biochemistry and protein fractions, are presented.