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1.
Acta Neurol Scand ; 124(1): 59-63, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21649602

ABSTRACT

BACKGROUND: Ventilatory involvement is rarely reported in chronic inflammatory demyelinating polyneuropathy (CIDP), but small prospective studies showed frequent involvement of phrenic nerves, which is usually overshadowed by severe limb weakness. OBJECTIVES: To report the clinical features of CIDP associated with ventilatory failure. RESULTS: There were seven patients (43% women), with a mean age of 58.6 (range 38-82). The clinical courses were relapsing in five and progressive in two. Four patients had an initial event simulating Guillain-Barre syndrome (GBS). Ventilatory failure was recurrent in three patients. Five patients had full or nearly complete recoveries; one still requires nocturnal ventilation; and one died (14%) of myocardial infarction while still requiring mechanical ventilation. CONCLUSIONS: Clinical ventilatory dysfunction in CIDP is usually not an indicator of poor prognosis, and many patients recover without significant permanent disability. The mortality rate is similar to intubated patients with GBS. Patients with cardiopulmonary comorbidities and acute GBS-like onset of CIDP may be at higher risk of ventilatory failure which typically responds to 'standard' treatments of CIDP. Larger prospective studies are needed to define the prevalence, clinical spectrum and significance of ventilatory involvement in CIDP and to establish guidelines for evaluation and treatment.


Subject(s)
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis , Respiratory Insufficiency/diagnosis , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/complications , Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/physiopathology , Respiratory Insufficiency/complications , Respiratory Insufficiency/physiopathology , Retrospective Studies
2.
Chirurgia (Bucur) ; 98(6): 553-60, 2003.
Article in Romanian | MEDLINE | ID: mdl-15143613

ABSTRACT

This paper aim is to present the case of a 72 year old male, diagnosed with functional secondary megaduodenum. We intend to discuss the pathogenic and positive diagnostic difficulties (the presence or absence of a mechanical obstructive factor or the participated of the megaduodenum in an intestinal pseudo-obstruction syndrome). Also we outline the rare frequency of this disease and especially the therapeutic difficulties: inefficiency of conservatory treatment, delicate problems of surgical tactics and technique.


Subject(s)
Duodenal Diseases/diagnosis , Intestinal Pseudo-Obstruction/diagnosis , Aged , Duodenal Diseases/etiology , Duodenal Diseases/surgery , Duodenum/abnormalities , Duodenum/diagnostic imaging , Duodenum/surgery , Humans , Intestinal Pseudo-Obstruction/etiology , Intestinal Pseudo-Obstruction/surgery , Male , Radiography , Treatment Outcome
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