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1.
Clin Plast Surg ; 48(4): 599-606, 2021 Oct.
Article in English | MEDLINE | ID: mdl-34503720

ABSTRACT

The eighth edition of the American Joint Committee on Cancer melanoma staging system relies on assessments of the primary tumor (T), regional lymph nodes (N), and distant metastatic sites (M). Its notable updates include tumor thickness measurements to the nearest 0.1 mm, revision of T1a and T1b definitions, re-evaluation of N category descriptors, increased number of stage III subgroupings, and incorporation of a new M1d designation, among others. These changes were based on analyses of a large contemporary international melanoma database. Ultimately, these revisions were made to improve staging and prognostication, risk stratification, and selection of patients for clinical trials.


Subject(s)
Melanoma , Skin Neoplasms , Humans , Lymphatic Metastasis , Melanoma/pathology , Neoplasm Staging , Prognosis , United States/epidemiology
2.
Clin Plast Surg ; 48(4): 617-629, 2021 Oct.
Article in English | MEDLINE | ID: mdl-34503722

ABSTRACT

As our knowledge and understanding of melanoma evolve, melanoma surveillance guidelines will reflect these findings. Currently, there is no consensus across international guidelines for melanoma follow-up. However, it is accepted that more aggressive surveillance is recommended for more advanced disease. When examining high-risk individuals, a systematic approach should be followed. Future considerations include the use of noninvasive imaging techniques, 'liquid biopsies,' and artificial intelligence to enhance detection of melanomas.


Subject(s)
Melanoma , Skin Neoplasms , Artificial Intelligence , Follow-Up Studies , Humans , Melanoma/diagnostic imaging , Skin Neoplasms/diagnostic imaging
3.
Dermatol Online J ; 24(7)2018 Jul 15.
Article in English | MEDLINE | ID: mdl-30261565

ABSTRACT

The role of biologic therapies in the field of dermatology continues to evolve as newer drugs and biosimilars are introduced to the U.S. market. Prescribing patterns and expenditures regarding biologic drugs are not well described. To address this knowledge gap, a retrospective review was conducted using the Medicare Provider Utilization and Payment Data: Part D Prescriber dataset between January 1st, 2013 and December 31st, 2015. The primary outcome was claims per provider per calendar year. Secondary outcomes included drug cost, shared cost per dermatologist, and practice location. Median claims per provider remained stable between 2013 and 2014 (24 versus 23, respectively; P=0.64). The majority of 2015 claims were for adalimumab (50.1%) and etanercept (41.4%). Total spending from Medicare payment data for biologic drugs prescribed by Ohio dermatologists increased by $3 million during the study period. The Gini coefficient for provider contributions to overall costs was 0.47, indicating moderate inequality among Ohio dermatologists. Spending associated with biologic drugs used for dermatologic indications is increasing in Ohio. As the market changes, providers should be aware of these patterns to better care for patients in need of biologic therapies.


Subject(s)
Biological Products/therapeutic use , Dermatologic Agents/therapeutic use , Dermatology/trends , Drug Prescriptions/statistics & numerical data , Practice Patterns, Physicians'/trends , Skin Diseases/drug therapy , Adalimumab/economics , Adalimumab/therapeutic use , Antibodies, Monoclonal/economics , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Biological Products/economics , Cost Sharing , Dermatologic Agents/economics , Dermatology/statistics & numerical data , Etanercept/economics , Etanercept/therapeutic use , Humans , Medicare Part D/statistics & numerical data , Ohio , Practice Patterns, Physicians'/statistics & numerical data , Retrospective Studies , United States , Ustekinumab/economics , Ustekinumab/therapeutic use
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