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1.
Acta Gastroenterol Belg ; 80(2): 313-315, 2017.
Article in English | MEDLINE | ID: mdl-29560699

ABSTRACT

Long-life immunosuppressive therapy increases the risk of de novo tumors in liver transplant recipients by decreasing the immune surveillance against malignant cells and oncogenic viruses. However, no cases of colon precancerous lesions have been reported in these subjects. Patient n. 1, a 73 yrs old male treated with calcineurin and purine synthesis inhibitors, showed at a per-protocol colono-scopy a 3 cm laterally spreading tumor (LST). Patient n. 2, a 73 yrs old male treated with calcineurin inhibitors, showed at a screening colonoscopy an LST occupying one third of the lumen circumference. Both subjects were asymptomatic, had been transplanted 14 years before, and in both cases, lesions showed severe dysplasia. LSTs represent 17.2% of advanced colorectal neoplasia (CRC) and risk factors are multifactorial. Immunosuppression may play a role which is however not completely understood. Based on this report, surveillance colonoscopy in liver transplanted patients should be considered.


Subject(s)
Colonoscopy/methods , Cyclosporine , Endoscopic Mucosal Resection/methods , Liver Transplantation/methods , Mycophenolic Acid , Precancerous Conditions , Tacrolimus , Aged , Cyclosporine/administration & dosage , Cyclosporine/adverse effects , Cyclosporine/immunology , Humans , Immune System/drug effects , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/immunology , Intestinal Mucosa/pathology , Intestinal Mucosa/surgery , Male , Mycophenolic Acid/administration & dosage , Mycophenolic Acid/adverse effects , Mycophenolic Acid/immunology , Precancerous Conditions/diagnosis , Precancerous Conditions/etiology , Precancerous Conditions/surgery , Tacrolimus/administration & dosage , Tacrolimus/adverse effects , Tacrolimus/immunology , Treatment Outcome
3.
Acta Gastroenterol Belg ; 77(1): 18-24, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24761687

ABSTRACT

BACKGROUND: Alcohol consumption by adolescents and young adults is an issue of significant public concern. Internet-based Social Networking sites, such as Facebook, are potential avenues to reach young people easily. OBJECTIVE: to underline the innovation in proposing surveys to collect health-related information regarding young people alcohol consumption and other substances abuse by using Social Networking Websites, particularly Facebook. METHODS: A questionnaire investigating modalities of alcohol consumption, drinking patterns' risk behaviors and other substances abuse was proposed through a "Facebook event" to young Italian Facebook users aged between 16 and 32. Each Facebook user invited to the event was free to participate, to answer to the questionnaire and to invite his "Facebook friends". RESULTS: During the 89 days of permanence on the Social Network, 1846 Facebook users participated the event and 732 of them decided spontaneously to answer the questionnaire. The frequency of answering was 8.2 people per day. About 200 users wrote a positive comment to the initiative on the wall of the event. Sixty% of subjects participating the survey were females. Ninety-one% of people answering the questionnaire were alcohol consumers. More than 50% of alcohol consumers were also smokers. Approximately 50% of subjects were binge drinkers. Illegal drugs were used by the 22.2% of the interviewed people. CONCLUSIONS: Facebook resulted an efficient and rapid tool to reach young people from all over Italy and to propose surveys in order to investigate alcohol consumption and alcohol-related health problems in the youth.


Subject(s)
Alcohol Drinking/epidemiology , Alcohol-Related Disorders/epidemiology , Social Media , Adolescent , Adult , Female , Humans , Italy , Male , Surveys and Questionnaires , Young Adult
4.
Transplant Proc ; 44(7): 2005-6, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22974893

ABSTRACT

Excessive weight gain, hypertension, hyperlipidemia, and diabetes are frequently observed among orthotopic liver transplantation (OLT) patients. These alterations, which are probably multifactorial in origin, contribute to posttransplantation metabolic syndrome (PTMS), which increases the risk of cardiovascular events. We assessed the prevalence of PTMS (diagnosed according to modified NCEP Adult Treatment Panel III criteria) in 156 OLT patients undergoing regular follow-up after transplantation (median 68 months; range, 6 to 234 months). Several pre- and post-OLT data were collected to identify the factors associated with the presence of PTMS which was found in 28% of cases. The only independent predictive factors for PTMS were diabetes mellitus and patients who were overweight or obese before-OLT. The prevalence of PTSM was lower among patients on tacrolimus immunosuppression. In our population, 21% of patients showed a high cardiovascular risk score with a 4% incidence of cardiovascular events, which was higher among subjects with PTMS. Close follow-up is mandatory to prevent the development of PTMS mainly among overweight and diabetic patients before transplantation.


Subject(s)
Cardiovascular System/physiopathology , Metabolic Syndrome/complications , Humans , Metabolic Syndrome/surgery
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