ABSTRACT
The fatty acid composition of phospholipids was studied in different actinomycetes growing in two media in order to detect their biological activity. The total phospholipids of the actinomycetes did not differ qualitatively and their composition was represented by the same series of fatty acids (C13--C19). The qualitative composition and the quantitative content of fatty acids in phospholipids depended on the composition of the growth medium. When the actinomycetes were cultivated in a complex medium, the proportion between fatty acids (C14:0, C14:1, C16:0, C17:0, C17:1, C18:1, C18:2) changed. The qualitative composition of fatty acids in phospholipids varied among the cultures. However, the content of palmitoleic, palmitic and oleic acids was elevated in all of the cultures. Under the given experimental conditions, the actinomycetes were found to synthesize phospholipids containing fatty acids with a high degree of unsaturation (mainly at the account of C16:1 and C18:1 acids).
Subject(s)
Fatty Acids/analysis , Phospholipids/analysis , Streptomyces/analysis , Chemical Phenomena , Chemistry , Species Specificity , Streptomyces griseus/analysisABSTRACT
Biological activity of lipid fractions of actinomycetes was examined on microorganisms and laboratory animals. The anabolic effect of the acetone fraction of Actinomyces aurigineus 2377 (on Wistar female rats), anabolic effect of sterols of Actinomyces griseus 15 (on chicks), and the high growth stimulating effect (up to 40-60%) of sterols of Actinomyces canosus 89 (on rats) were noted. The estrogenic effect of sterols of Act. griseus 15, Act. griseus 20 and Act. albodenitrificans 13a on the sex system was shown. The antimicrobial properties of lipid fractions differed in their selectivity with respect to the test organisms and depended also on the actinomycete species and cultivation conditions.
