1.
Eksp Klin Farmakol
; 70(4): 32-4, 2007.
Article
in Russian
| MEDLINE
| ID: mdl-18078040
ABSTRACT
The effects of four new fluorine-containing pinacidyl analogs (FPs) on the bladder contractile function in vitro and in vivo, and on the vessel tone in vitro were examined. All the four drugs produced a concentration-dependent relaxation of isolated rat detrusor strips and isolated aorta rings. The contractility inhibition effect of compound FP-5 was decreased by preliminary glibenclamide perfusion. This compound also effectively inhibited bladder contractility function in vivo.