[Changes in the structures of the cerebral cortex in experimental atherosclerosis with and without exposure to sound]. / Izmeneniia struktur kory mozga pri éksperimental'nom ateroskleroze i ego sochetanii s deistviem zvuka.

Albino rats fed an atherogenic diet for 3 months developed a marked depression of the anti-coagulation system of blood. The acoustic and sensomotor cortex showed dystrophic changes in the cortical structures, as well as signs of the reparative nature. Sound stimulation in the presence of atherosclerosis increased fibrinolytic activity and decreased heparin tolerance of blood plasma in animals sensitive to acoustic exposure and led to a greater severity and dissemination of dystrophic and destructive changes in the cortical structures, particularly in animals with convulsive seizures.

[Epileptic seizures in experimental atherosclerosis]. / Epilepticheskie pripadki pri éksperimental'nom ateroskleroze.

Case histories of 900 patients suffering from cerebrovascular diseases were analyzed. In 25 of them (2.8%) the disease got complicated with epileptic seizures. In 142 albino rats over 2 years of the age, both "sensitive" and "insensitive" to acoustic stimuli experimental atherosclerosis was induced by their long-time (for 3 to 5 months) keeping on Wilgram's atherogenic diet. As a result of the experiment it has been found that the atherogenic diet was conducive to development of hypercholesterolemia and depression of the blood anticoagulation system. As early as a month after the beginning of the diet application substantial shifts in the function of the central nervous system set in. These shifts were characterized by a shortening of the latent period of the reaction and the seizure and an intensification of the latter. The atherogenic diet led to development of audiogenic seizures in rats formerly insensitive to acoustic stimuli. Transfer of the animals to a cholesterol-free ration resulted in normalization of the blood anticoagulation system in 2 to 3 months. Within the same period the basic indices of the audiogenic reaction got normal, and the intensity of the epileptic seizures decreased.

[Epileptic seizures in stenosis and de-stenosis of the common carotid arteries]. / Epilepticheskie pripadki pri stenoze i destenoze obshchikh sonnykh arterii.

Experiments were performed in 64 white laboratory rats sensitive to acoustic stimula with disturbances and a restitution of cerebral circulation due to stenosis and destenosis of the common carotid arteries. The epileptic reaction of rats was studied prior to and following stenosis and destanosis by means of audiogenic epilepsy. In highly sensitive rats of the KM strain with a leftside stenosis of the common carotid arteries the epileptical reaction did not change significantly. In rats, selected from a random population after a simultaneous bilateral stenosis of the common carotid arteries there was an intensification of epileptical seizures in 70,6%. The restitution of the blood flow after 10 days following stenosis of the common carotid arteries facilitated a drop of the convulsive reaction. In animals who were not operated for the restitution of the blood flow in the common carotid arteries the reaction remained high even after 3 months following disturbances of cerebral circulation.