[The clinical picture, classification and surgical treatment of paraffinomas of the external genitalia]. / Klinika, klassifikatsiia i operativnoe lechenie oleogranulem naruzhnykh polovykh organov.

Basing on operative data on 42 patients and literature data, the authors hold that clinical presentation of external genitalia paraffinomas varies depending on the quantity of the introduced emulsion, its chemical structure, site and depth of the injection, duration of the suspension stay in the tissues. Paraffinoma dissection within intact tissue is thought the only and radical treatment. The technique should be based on adequate classification of the disease taking into consideration clinical varieties, localization and extent of the process, involvement of the adjacent tissues, complications. Four forms of the disease are recognized: foreskin, stem, penile-scrotal, penile-pubic-scrotal. Etiological factors, spread of the disease, kind of complication are considered also. The classification permits unification of surgery, reliable comparison of the results from various institutions. In preputial complicated disease a simple policy is employed--circular dissection of the foreskin. Radical dissection of the affected skin with subcutaneous fat and plastic repair of the defect with a scrotal skin double-end graft according to Reich's technique in modification of the authors or replacement of the wound-adjacent triangle grafts according to A. A. Limberg. Utilization of this approach led to substantial improvement of end results in the treatment of 39 patients.

[Effect of new antihistaminic preparations on the body's immunologic reactivity]. / Vliianie novykh protivogistaminovykh preparatov na immunologicheskuiu reaktivnost' organizma.

The effect of new antihistaminic drugs, phencarol and bicarphen, on immunologic reactivity of experimental animals was studied in comparison with diphenhydramine. Phencarol and bicarphen inhibited the delayed type allergic reactions to a greater degree than diphenydramine. Unlike diphenhydramine, phencarol and bicarphen injected simultaneously with test-antigen markedly decreased the number of rosette-forming lymphocytes in the immunocompetent organs (spleen, thymus, lymph nodes). Phencarol, bicarphen and diphenhydramine produced the same inhibitory effect on the content of antibody-producing cells in the spleen of mice.

[Effect of fenformin, L-DOPA and para-chlorophenylalanine on the immunological reactivity and chemical carcinogenesis in BALB/c mice]. / Vliianie fenformina, L-DOFA i parakhlorfenilalanina na immunologicheskuiu reaktivnost' i razvitiie khimicheskogo kantserogeneza u myshei BALB/c.

Treatment with 20-methylcholanthrene resulted in the increase in hypothalamic levels of noradrenaline and serotonin in BALB/c mice. Immunization of carcinogen-treated animals with ovine erythrocytes was followed by changes in the hypothalamic levels of central neurotransmitters, opposite to those in intact immunized controls. After correction of the levels of neurotransmitters in the hypothalamus with phenformin, parachlorophenylalanine or L-dopa carried out prior to immunization, the fraction of antibody-producing cells in the spleen of carcinogen-treated mice returned to normal. A combined administration of immunostimulators and drugs for correction of hypothalamic levels of noradrenaline and serotonin potentiated inhibitory effect of the former on chemical carcinogenesis.

[Changes in immune reactivity of the organism and content of monoaminodicarboxylic acid and their derivatives in brain and spleen]. / Izmenenie immunologicheskoi reaktivnosti organizma i soderzhanie monoaminodikarbonovykh kislot i ikh proizvodnykh v golovnom mozge i selezenke.

It is established in experiments with mice that the contrary effects on the immune system caused different changes in the level of monoaminodicarboxylic acids and their derivatives in the brain and spleen structures. While immunostimulation was accompanied by an increase in monoaminocarboxylic acids, immunodepression, on the contrary, was characterized by a decrease in their contents up to the level, which is lower than the initial one. The main task of the investigation was to find out if this correlation is of causal character, which might be indicative of the significance of maintaining the definite level of monoaminodicarboxylic acids and their derivatives in the brain immunocompetent organs for normal functioning of the immune system.