[Atmospheric pollution as a health risk factor in children and adolescence]. / Atmosfernye zagriazneniia kak faktor riska dlia zdorov'ia detskogo i podrostnovogo naseleniia.

Atmospheric pollution is an essential health risk factor. The present-day considerable rise in the incidence and prevalence of diseases among children and adolescents suggest that there is an excess of ecological pressure above the body's functional capacities of their adaptation. Children of the first year of life are the most vulnerable group. They are at the highest risk of death and disease with high technogenic loads (2.15-6.33 units).

[The determination of ethylene glycol in blood and urine]. / Opredelenie étilenglikolia v krovi i moche.

Method of ethylene glycol isolation from blood and urine with subsequent gas-chromatographic determination was developed. The method makes it possible to extract 60-80% of ethylene glycol and to detect its toxic concentration in the cadaveric blood and urine.

[The effect of narcotic analgesics on the central nervous system as an index of their drug addiction potential]. / Vliianie narkoticheskikh anal'getikov na tsentral'nuiu nervnuiu sistemu kak pokazatel' ikh toksikomanicheskogo potentsiala.

The relationship between the average effective doses causing disturbances of the statokinetic reflex and the average effective doses of the analgesic and hyperthermic actions of morphine, fentanyl, codeine and tilidine was studied in the experiments on Wistar rats. The effective analgesic and hyperthermic doses of morphine (the agent with the highest drug-addiction properties) approach the dose inducing coordination disorders. In this respect fentanyl and codeine are close to morphine. The effective doses of tilidine (the agent with the lowest drug-addiction properties among the studied agents) possess significant differences. The importance of the relationship between the mentioned effective doses and the drug-addiction properties of the analgesics.

[A neuropharmacological study of a hydroxazine derivative]. / Nevrofarmakologichno prouchvane na edno khidroksazinovo proizvodno.

Neuropharmacological studies with the compound 2-methyl, 3-phenyl, 3-methyltransxydroxasino-propiophenon hydrochloride with cipher PS1, were carried out on rats as well as follow-up of development of drug dependence after continuous usage of the substance. The obtained showed that the compound S1 had stimulating influence on the central nervous system of amphetamine-like type. After prolonged administration of amphetamine and the compound PS1 it was established in rats that amphetamine induced development of tolerance and occurrence of hypersensitivity during withdrawal. The compound PS1 did not cause similar changes in rats after its chronic administration.

[Liposomal systems--prospective drug forms. II. The creation and characterization of liposomal systems for the oral use of narcotic analgesics]. / Lipozomni sistemi--perspektivni lekarstveni formi. II. Suzdavane i okharakterizirane na lipozomni sistemi za oralno prilozhenie na narkotichni analgetitsi.

Liposomal systems were prepared for oral usage of narcotic analgesics morphine and phentanyl. The systems were examined for homogeneity in respect to seize size and form of liposomal structures by a diffraction-laser method and electron microscopy. The liposomal drug forms were studied on biological experiment as the change in the body temperature of rats was described. It was established that in rats oral usage of liposomal systems with morphine respectively with phentanyl caused significantly better effect in comparison with active substances, not taken in liposomes.

[Inhibition of morphine hyperthermia, induced by nicotinamide]. / Potiskane na morfinovata khipertermiia ot nikotinamid.

The effect of nicotinamide, administered immediately before the morphine or on the background of already developed morphine hyperthermic reaction, was studied on morphine hyperthermia. It was established that nicotinamide, administered before morphine, inhibited development of morphine hyperthermia, statistically significantly up to 120 min after administration of morphine. Nicotinamide, administered, on the 60th min after morphine injection, did not inhibit significantly the developed already hyperthermic reaction. In connection with the discussion of the established effects a series of experiments were carried out on N-demethylation of morphine and nicotinamide influence on in vitro. These experiments proved that nicotinamide inhibited noncompetitive demethylation of morphine.