THE EFFECT OF COGNITIVE-BEHAVIORAL THERAPY ON INDICATORS OF LIPID AND CARBOHYDRATE METABOLISM IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE ON THE BACKGROUND OF ABDOMINAL OBESITY.

OBJECTIVE: The aim: Analyse the impact and effectiveness of cognitive-behavioural therapy in patients with NAFLD on the background of AO on indicators of lipid and carbohydrate metabolism. PATIENTS AND METHODS: Materials and methods: 85 patients with NAFLD and obesity of the 1st degree (42 women, 43 men) were examined. All patients were divided into two clinical groups: 1st group (research) - 48 people, who underwent a course of CBT for 6 months; the control group - 37 people, who followed only diet therapy, recommended physical activity, without involvement in CBT. The general clinical examination of patients consisted of the measurement of anthropometric and physiological indicators, the study of lipid and carbohydrate profile indicators. RESULTS: Results: After a 6-month course of CBT, a decrease in the atherogenic coefficient (AC) was recorded in the patients of the 1st group in 2.29 times (p=0.037<0.05), the number of patients with hypertension of the 1st degree decreased in 1.8 times (p=0.0047<0.05) in comparison with the initial indicators (on the 1st day) and amount of patients with normal blood pressure of the 1st group increased by 2.4 times (p=0.0115<0.05) compared to the control group. CONCLUSION: Conclusions: The course of CBT should be an integral component in the program for the management of obese patients to optimize not only the psycho-emo¬tional condition, but also to correct lipid and carbohydrate metabolism indicators, reduce the risk of developing cardiovascular and neurological complications.

EATING BEHAVIOUR AND OBESITY: GENDER-AGE FEATURES.

OBJECTIVE: The aim: Identify the types of eating behaviour in overweight and obesity depending on gender and age. PATIENTS AND METHODS: Materials and methods: A survey of 210 people (men -105, women -105) was conducted. The age of women ranged from 19 to 60 years, the average age was 41.5 ± 11.2 years. The age of men ranged from 22 to 60 years, the average age was 42.3 ± 12.3 years. The examined patients were divided into two clinical groups: group I - 70 people (women - 35, men - 35) with overweight. BMI of persons of the I group from 25.8 kg / m2 to 29,3 kg / m2 (BMTmid. = 27,5 ± 1,31 kg / m2); Group II - 72 people with 1st degree obesity (women -36, men - 36). Evaluation of eating disorders was carried out using the DEBQ questionnaire (Nederland) adapted to the purpose of the study. RESULTS: Results: In patients of groups I and II healthy type of eating behaviour was recorded less often than in control groups, 5.38 times (D = 13.561, p = 0.002 <0.05) and 10.45 times (D = 21.043, p = 0.022 <0.05), respectively. In group I, the restrictive type of EB among women occurred 1.7 times more often than in men (D = 0.852, p = 0.001). In group II, the restrictive type of EB among women was observed 1.3 times more often than in men (D = 0.382, p = 0.005). CONCLUSION: Conclusions: Restrictive eating behaviour disorders are one of the leading factors in the development of overweight and obesity. Correction of eating disorders in obese people must be carried out taking into account the gender and age characteristics of the patient, to obtain positive results for a shorter course of treatment.

Medico-social value of osteoarthritis. secondary prevention and treatment of osteoarthritis in comorbidity with chronic gastritis.

OBJECTIVE: Introduction: Medico-social significance of osteoarthritis is due to a number of factors, one of which is associated with the need for long-term anti-inflammatory therapy, which is associated with undesirable side effects. The aim: Identify the features of the course of chronic gastritis in patients taking selective NSAIDs for osteoarthritis. PATIENTS AND METHODS: Materials and methods: Were examined 122 patients with osteoarthrosis, who had verified chronic gastritis in the anamnesis (50 males and 72 females), aged from 42 to 64. Control group included 40 patients with osteoarthrosis without gastroduodenal zone pathology in the anamnesis. For arthralgia relief, patients were prescribed to intake meloxicam (average dose - 12.5±1.39 mg/day) or nimesulide (average dose - 150±14.91 mg/day). RESULTS: Results: It was determined that prescription of selective NSAIDs (meloxicam and nimesulide) raised the risk of NSAIDs gastropathy/dyspepsia in 2.9 times (P<0.03) in patients with chronic gastritis in the anamnesis than in patients without associated gastroduodenal zone pathology. Atrophy of gastric mucous membrane was associated with higher risks (P>0.05) of erosive gastropathy. CONCLUSION: Conclusions: With the purpose of gastropathy prevention upon taking NSAIDs, patients with chronic gastritis in the anamnesis are recommended to undergo gastroprotective therapy.

Methods of transmission and features of the course of hepatitis c virus infection in children: medical and social aspects.

OBJECTIVE: Introduction: Hepatitis C virus (HCV) infection is a major global problem. According to WHO, 150-200 million people globally have hepatitis C infection. Even though HCV infection morbidity rate in children is relatively low in comparison with the adult population, approximately 5 million children in the world have active HCV. There is a number of differences between HCV infection in adults and in children. However, the data pertaining to this issue is controversial. The aim: Research, analysis and synthesis of information from contemporary literature on transmission of infection and characteristics of the course of HCV infection in children. PATIENTS AND METHODS: Materials and methods: Analysis and synthesis of information from contemporary literature on transmission of infection and characteristics of the course of HCV infection in children were conducted. CONCLUSION: Conclusions: Information from literature of the latest years on peculiarities of infection, disease course and complications of HCV infection in children was analyzed and summarized in this article.