[Peculiarities of diurnal profile of arterial blood pressure in clinically healthy elderly persons]. / Osobennosti sutochnogo profilia arterial'nogo davleniia u klincheski zdorovykh pozhilykh i starykh liudei.

The diurnal profile peculiarities in normotensive elderly persons have been shown. The variability ranges of systolic arterial blood pressure are discussed.

[Analysis of rheologic changes in blood based on a hemorheologic profile concept]. / Analiz reologicheskikh izmenenii krovi na osnove kontseptsii gemoreologicheskogo profilia.

Changes in blood rheology were studied in 106 female hypertensive patients. Basic parameters of blood rheology were recorded: total blood viscosity, plasma viscosity, Hct, erythrocyte aggregation and deformability, fibrinogen, albumin/globulin ratio, and Hct/eta ratio. This set of parameters was presented as the hemorrheological profile. Blood and plasma viscosities were increased in hypertensive patients in comparison with the controls. Therapy with pentoxifylline (600-800 mg/day for 4 weeks) or angiotensin II receptor antagonist losatran (50 mg/day for 4 weeks) resulted in positive changes in the hemorrheological profile.

[Spirapril - a new long-acting ACE inhibitor: efficacy and safety in patients with arterial hypertension in combination with diabetes mellitus and impaired kidney function]. / Spirapril - novyi ingibitor angiotenzinprevrashchaiushchego fermenta dlitel'nogo deistviia: éffektivnost' i bezopasnost' u bol'nykh arterial'noi gipertoniei v sochetanii s sakharnym diabetom i narushennoi funktsiei pochek.

AIM: To examine effectiveness and safety of quadropril. MATERIAL AND METHODS: Changes in blood pressure (BP), heart rate (HR), levels of glucose, potassium and creatinine, creatinine clearance were studied in 120 patients (48 males and 72 females, mean age 60.6 +/- 0.7 years) with mild to moderate arterial hypertension (AH) with average duration 13.8 +/- 0.7 years. The patients were divided into 3 groups: with AH (n = 40), AH + noninsulindependent diabetes mellitus (DM) (n = 43), AH and nephropathy (n = 37). 8-week treatment was performed with a standard dose of 6 mg/day (1 tablet of quadropril). Control examinations were made 2, 4 and 8 weeks after the treatment. RESULTS: After 8 weeks of treatment a decrease in systolic blood pressure in AH group was 24.0 +/- 3.0 mm Hg and in diastolic blood pressure 16.3 +/- 1.3 mm Hg (P < 0.001). In the group with DM this decrease was 22.4 +/- 2.8 mm Hg and 15.7 +/- 1.4 mm Hg (p < 0.001), respectively. In the group with nephropathy this decrease was 26.4 +/- 2.4 and 16.5 +/- 1.3 mm Hg (p < 0.001), respectively. Heart rate changed significantly only in diabetics: from 75.1 +/- 1.7 to 72.9 +/- 1.3 beats/min. Biochemical parameters in the hypertensive and diabetic patients did not change significantly. In the nephropathy group there was a significant decrease in creatinine and increase in creatinine clearance. Their level of glucose and potassium changed insignificantly. CONCLUSION: The treatment with quadropril results in a significant decrease in blood pressure, does not influence parameters of carbohydrate metabolism, improves nitrogen eliminating function of the kidneys.

[Hemorheological profiles in patients with arterial hypertension and bronchial asthma]. / Gemoreologicheskie profili u patsientov s arterial'noí gipertenzieí i bronkhial'noí astmoí.

Hemorheological parameters were studied in patients with essential hypertension (men and women) and those with bronchial asthma. The rheological findings were established as a hemorheological profile. The latter is a set of macro- and microrheological parameters under various pathological conditions. The data show that blood viscosity was increased and correlate with blood pressure in hypertensive patients. There were more significant changes in the male populations of the two groups. The main cause of decreased blood fluidity and oxygen transport efficiency under these conditions is associated with hemoconcentration, elevated plasma levels of protein and increased plasma viscosity. The findings suggest that with the concept of a hemorheological profile one can correct rheological disturbances under various clinical conditions.