ABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Climacteric , Nutritional Support/methods , Body Composition , Electric Impedance , Evaluation of the Efficacy-Effectiveness of InterventionsABSTRACT
BACKGROUND: Osteoporosis is one of the most important public health problems involving a high percentage of costs in the medical care system. Reliable diagnostic techniques for an early detection of bone deterioration and studies of factors that influence its development in menopausal women are crucial. The aim of the study was to determine the relationship between bone microarchitecture and anthropometry in climacteric women. METHODS: Women were recruited at the Menopause Clinic, University Hospital of FMRP/USP, and submitted to anthropometry and to the evaluation of bone quality (Ultrasound Bone Profile Index, UBPI) and quantity (Amplitudedependent Speed of Sound, AD-SoS-) by phalangeal quantitative osteosonography (DBM Sonic BP). Descriptive analysis of the data was reported and a multiple linear regression was performed using the software SAS® 9.0. RESULTS: 71 patients aged 58 ± 7 y were studied: 28% had BMI 18.5-24.9 kg/m(2), 35% BMI 24.9-29.9 and 37% BMI > 30. Mean AD-SoS was 2059 ± 79 m/s and mean UBPI was 0.67 ± 0.13. Considering AD-SoS the dependent variable, there was no statistically significant relationship between age (p = 0.20), BMI (p = 0.76), fat mass by bioelectrical impedance (p = 0.42) and by anthropometry (p = 0.95). The variables had very low effect on the UBPI when it was considered the dependent variable. CONCLUSIONS: The relation between bone microarchitecture and the anthropometry of the women studied shows that, the greater the bone quantity, the better the anthropometric parameters, without statistically significance. This work was a cross-sectional study on a small sample that needs to be validated in a prospective design.
Subject(s)
Bone Density/physiology , Bone and Bones/anatomy & histology , Climacteric/physiology , Absorptiometry, Photon , Anthropometry , Body Mass Index , Bone and Bones/diagnostic imaging , Electric Impedance , Female , Humans , Linear Models , Middle Aged , Skinfold Thickness , Ultrasonography , Waist-Hip RatioABSTRACT
Background: Osteoporosis is one of the most important public health problems involving a high percentage of costs in the medical care system. Reliable diagnostic techniques for an early detection of bone deterioration and studies of factors that influence its development in menopausal women are crucial. The aim of the study was to determine the relationship between bone microarchitecture and anthropometry in climacteric women. Methods: Women were recruited at the Menopause Clinic, University Hospital of FMRP/USP, and submitted to anthropometry and to the evaluation of bone quality (Ultrasound Bone Profile Index, UBPI) and quantity (Amplitudedependent Speed of Sound, AD-SoS-) by phalangeal quantitative osteosonography (DBM Sonic BP). Descriptive analysis of the data was reported and a multiple linear regression was performed using the software SAS® 9.0. Results: 71 patients aged 58 ± 7 y were studied: 28% had BMI 18.5-24.9 kg/m2, 35% BMI 24.9-29.9 and 37% BMI > 30. Mean AD-SoS was 2059 ± 79 m/s and mean UBPI was 0.67 ± 0.13. Considering AD-SoS the dependent variable, there was no statistically significant relationship between age (p = 0.20), BMI (p = 0.76), fat mass by bioelectrical impedance (p = 0.42) and by anthropometry (p = 0.95). The variables had very low effect on the UBPI when it was considered the dependent variable. Conclusions: The relation between bone microarchitecture and the anthropometry of the women studied shows that, the greater the bone quantity, the better the anthropometric parameters, without statistically significance. This work was a cross-sectional study on a small sample that needs to be validated in a prospective design (AU)
Introducción y objetivo: La osteoporosis es uno de los problemas más importantes de la Salud Pública e involucra un elevado porcentaje de los costos del Sistema de Salud. Es decisiva la aplicación de técnicas confiables de diagnóstico para la detección precoz del deterioro óseo y estudios de los factores que influencian su desarrollo en mujeres postmenopáusicas. El objetivo del estudio fue determinar la relación entre la micro arquitectura ósea y la antropometría de mujeres postmenopáusicas. Métodos: Se reclutaron mujeres, en el dispensario de Climaterio del Hospital Universitario (FMRP/USP), que fueron sometidas a antropometría y evaluación de la calidad ósea (Índice Ultrasonográfico del Perfil Óseo-UBPI) y de la cantidad ósea (Velocidad del Sonido dependiente de la Amplitud-Ad-SoS) por medio de la osteosonografía cuantitativa de falange (DBM Sonic BP). Se realizaron análisis descriptivos de los datos y regresión lineal múltiple utilizando el software SAS® 9.0. Resultados: Se estudiaron 71 pacientes con edad media de 58 ± 7 años: 28% tuvieron el IMC entre 18,5-24,9 kg/m2, 35% entre 24,9-29,9 y 37% IMC arriba de 30. La media del Ad-SoS fue 2.059 ± 79 m/s y del UBPI fue 0,67 ± 0,13. Considerando el Ad-SoS como la variable dependiente, no hubo relación estadísticamente significativa entre la edad (p = 0,20), IMC (p = 0,76), masa grasa por la impedancia bioeléctrica (p = 0,42) y por la antropometría (p = 0,95). Las variables tuvieron un efecto muy bajo en el UBPI cuando este fue considerado la variable dependiente. Conclusión: La relación entre la micro arquitectura ósea y la antropometría de las mujeres estudiadas mostró que cuanto mayor es la cantidad ósea, mejores son los parámetros antropométricos sin importancia estadística. Este trabajo fue un estudio transversal de una muestra pequeña, por lo cual necesita ser validado en un diseño prospectivo (AU)
Subject(s)
Humans , Female , Middle Aged , Bone Density , Osteoporosis, Postmenopausal/epidemiology , Anthropometry/methods , Osteoporosis, PostmenopausalSubject(s)
Climacteric/physiology , Climacteric/psychology , Counseling , Eating/psychology , Diet , Female , Health Education , Humans , Male , Middle Aged , Treatment FailureABSTRACT
OBJECTIVES: The methods currently available for the measurement of energy expenditure in patients, such as indirect calorimetry and double-labelled water, are expensive and are limited in Brazil to research projects. Thus, equations for the prediction of resting metabolic rate appear to be a viable alternative for clinical practice. However, there are no specific equations for the Brazilian population and few studies have been conducted on Brazilian women in the climacteric period using existing and commonly applied equations. On this basis, the objective of the present study was to investigate the concordance between the predictive equations most frequently used and indirect calorimetry for the measurement of resting metabolic rate. METHODS: We calculated the St. Laurent concordance correlation coefficient between the equations and resting metabolic rate calculated by indirect calorimetry in 46 climacteric women. RESULTS: The equation showing the best concordance was that of the FAO/WHO/UNU formula (0.63), which proved to be better than the Harris & Benedict equation (0.55) for the sample studied. CONCLUSIONS: On the basis of the results of the present study, we conclude that the FAO/WHO/UNU formula can be used to predict better the resting metabolic rate of climacteric women. Further studies using more homogeneous and larger samples are needed to permit the use of the FAO/WHO/UNU formula for this population group with greater accuracy.
Subject(s)
Basal Metabolism , Climacteric , Energy Metabolism , Mathematical Concepts , Adult , Aged , Calorimetry, Indirect , Female , Humans , Middle Aged , Retrospective StudiesABSTRACT
OBJECTIVE: To investigate the influence of a routine Brazilian diet on the rate of oxidation of energy substrates in climacteric, obese women, who came to the outpatient clinic of the Hospital of the School of Medicine of Ribeirao Preto (HCFMRP-USP). METHODS: Subjects were recruited from outpatients at the Climacteric Clinic of the HCFMRP-USP, who were aged between 39 and 65 years and who voluntarily agreed to participate in this study. They were submitted to anthropometric measurements and indirect calorimetry for resting energy expenditure and substrate oxidation rate determination. RESULTS: The carbohydrate oxidation in the group of climacteric, obese women showed a significant positive correlation between energy consumption at rest and ingestion of carbohydrates (in grams); the subjects' rate of lipid intake showed a significant negative correlation with their body mass index, waist circumference, and daily total caloric intake. CONCLUSION: Carbohydrate intake and carbohydrate oxidation rate may contribute to weight gain in climacteric women.
Subject(s)
Carbohydrate Metabolism/physiology , Climacteric/physiology , Diet, Reducing/methods , Dietary Carbohydrates/administration & dosage , Dietary Carbohydrates/metabolism , Motor Activity/physiology , Obesity/diet therapy , Adult , Body Mass Index , Brazil , Calorimetry, Indirect , Female , Humans , Lipids/blood , Middle Aged , Obesity/metabolism , Overweight/diet therapy , Oxidation-Reduction , Treatment OutcomeABSTRACT
The effects of administration of 1.25 mg testosterone propionate between the 2nd and 5th day of life on body weight, ovarian weight, food and water consumption, and the histochemical activity of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) were studied in female Wistar rats during the evolution of experimental micropolycystic ovaries. Biometric studies showed a 9.9 day delay of vaginal opening for the treated animals and that the increased body weight of the animals during the disease was not related to food intake and thus presumably due to the induced metabolic disorder. Reduced histochemical activity of the 17 beta-HSD of testosterone-treated rats was detected at ages 30, 60 and 90 days before the onset of morphological alterations of the ovaries. The possible participation of 17 beta-HSD in the disequilibrium between androstenedione and testosterone and in the genesis of the disease is discussed.
Subject(s)
17-Hydroxysteroid Dehydrogenases/metabolism , Body Weight/drug effects , Ovary/drug effects , Polycystic Ovary Syndrome/physiopathology , Sexual Maturation/drug effects , Testosterone/pharmacology , Animals , Female , Organ Size/drug effects , Ovary/pathology , Rats , Rats, Inbred StrainsABSTRACT
Obstetricians often have difficulty diagnosing rupture of fetal membranes because of several factors that interfere with the available tests. A new test is proposed herein, which is based on heating endocervical material on a glass slide for one minute. When the fetal membranes are ruptured, the material on the slide turns white; when they are intact, the material turns brown. The low cost, risk-free method is a simple procedure providing immediate results, thus making its use practical in daily practice.
Subject(s)
Fetal Membranes, Premature Rupture/diagnosis , Amniotic Fluid/cytology , Cervix Mucus/cytology , Diagnostic Errors , Female , Fetal Membranes, Premature Rupture/pathology , Humans , Methods , Pregnancy , Pregnancy Trimester, ThirdABSTRACT
Os autores estudaram as tecnicas mais utilizadas para a demonstracao da 3 beta esteroide-desidrogenase (3 beta ST-D) em ovario de ratas. Analisaram: como substrato a dehidroepiandrosterona (DHA) e a epiandrosterona (EPI); como solvente de substrato a acetona,o propileno-glicol e a dimetiformamida (DMF); como aceptores a nitrobluetetrazolium (NBT) e o tetranitrobluetetrazolium (TNBT); como coenzimas o NAD e NADP e as variacoes de pH (7,2, 7,4 e 7.6) em tampao fosfato 0,1 M. O meio de incubacao que forneceu os melhores resultados foi: 0,52 mM de NAD; 0,16 mM de TNBT 0,1 mM de substrato em tampao fostato 0,1 M pH 7,4
Subject(s)
Female , Rats , Ovary , OxidoreductasesABSTRACT
Os autores estudaram a atividade histoquimica da A-D II (alcool-desidrogenase secundaria) e da 3 beta.ST-D(3 beta esteroide-desidrogenase) nos foliculos em evolucao e corpos luteos humanos. As variacoes topografica e de intensidade das duas enzimas ilustram a importancia dos intercambios celulares para a sintese adequada dos esteroides ovarianos
